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Archita Das
Georgia Regents University
CardiologyATP7AAngiogenesisTranscription factorCell biology
23Publications
7H-index
169Citations
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Publications 24
Newest
#1Arundhati Jana (UIUC: University of Illinois at Urbana–Champaign)
#1Arundhati JanaH-Index: 16
Last. Barbara Jung (UIC: University of Illinois at Chicago)
view all 10 authors...
Background Colorectal cancer remains a deadly cancer due to metastatic disease. To understand the molecular mechanisms of metastasis in colon cancer, we investigated whether the copper chaperone antioxidant-1 (Atox1) protein plays a role in this process. Recent findings indicate that Atox1 protein has transcription factor activities and plays a vital role in cell proliferation in cancer cells. However, the role of Atox1 in metastasis has not been examined.
Source
#1Archita DasH-Index: 7
#2Dipankar AshH-Index: 1
Last. Masuko Ushio-FukaiH-Index: 42
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Introduction: Copper (Cu), an essential nutrient, and reactive oxygen species (ROS) play an important role in reparative angiogenesis with unknown mechanism. The Cu importer CTR1 at plasma membrane...
Objective: Copper (Cu) is essential micronutrient, and its dysregulation is implicated in aortic aneurysm (AA) development. The Cu exporter ATP7A (copper-transporting P-type ATPase/Menkes ATPase) d...
2 CitationsSource
#1Varadarajan Sudhahar (Georgia Regents University)H-Index: 2
#2Archita Das (Georgia Regents University)H-Index: 7
Last. Tohru Fukai (Georgia Regents University)H-Index: 4
view all 16 authors...
1 CitationsSource
#1Archita Das (Georgia Regents University)H-Index: 7
#2Varadarajan Sudhahar (Georgia Regents University)H-Index: 2
Last. Tohru Fukai (Georgia Regents University)H-Index: 4
view all 4 authors...
NADPH oxidase (NOX)-derived reactive oxygen species (ROS) and copper (Cu), an essential micronutrient, have been implicated in vascular inflammatory diseases. We reported that in proinflammatory cy...
Source
#1Archita DasH-Index: 7
#2Dipankar AshH-Index: 1
Last. Masuko Ushio-FukaiH-Index: 42
view all 9 authors...
Introduction: Reactive oxygen species (ROS) and copper (Cu), an essential micronutrient, play an important role in angiogenesis; however, their relationship in VEGF-induced angiogenesis in endothel...
#1Young-Mee Kim (Georgia Regents University)H-Index: 2
#2Seock-Won Youn (Georgia Regents University)H-Index: 2
Last. Masuko Ushio-Fukai (Georgia Regents University)H-Index: 4
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Summary Mitochondrial dynamics are tightly controlled by fusion and fission, and their dysregulation and excess reactive oxygen species (ROS) contribute to endothelial cell (EC) dysfunction. How redox signals regulate coupling between mitochondrial dynamics and endothelial (dys)function remains unknown. Here, we identify protein disulfide isomerase A1 (PDIA1) as a thiol reductase for the mitochondrial fission protein Drp1. A biotin-labeled Cys-OH trapping probe and rescue experiments reveal that...
23 CitationsSource
#1Archita DasH-Index: 7
Last. Tohru FukaiH-Index: 41
view all 7 authors...
Background: Copper (Cu) is implicated in inflammation and atherosclerosis with unknown mechanism. Cu chaperone Atox1 is recently discovered to function as a Cu-dependent transcription factor for NADPH oxidase organizer p47phox to promote ROS-dependent inflammatory gene expression in endothelial cells (ECs). However, mechanism of Atox1 nuclear translocation and its role in atherosclerosis remain unknown. SUMOylation can alter localization and transcriptional activity of proteins. Hypothesis: SUMO...
#1Archita DasH-Index: 7
#2Youngmee KimH-Index: 40
Last. Masuko Ushio-FukaiH-Index: 42
view all 7 authors...
Background: Reactive oxygen species (ROS) and copper (Cu), an essential micronutrient, play an important role in angiogenesis with unknown mechanisms. Cysteine sulfenic acid (Cys-OH) formation is i...
#1Sudhahar Varadarajan (UIC: University of Illinois at Chicago)H-Index: 3
#2Archita Das (UIC: University of Illinois at Chicago)H-Index: 7
Last. Tohru Fukai (UIC: University of Illinois at Chicago)H-Index: 41
view all 9 authors...
Introduction: Disturbed flow (d-flow) including oscillatory shear (OS) causes endothelial dysfunction, leading to atherosclerosis. SUMOylation alters localization and transcriptional activity of protein. Copper (Cu), an essential micronutrient, plays a pivotal role in inflammation. We recently reported that Cu transport protein, antioxidant 1 (Atox1) functions not only as Cu chaperone to activate secretory Cu enzymes via Cu exporter ATP7A, but also as Cu-dependent transcription factor for inflam...
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