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Archita Das
Georgia Regents University
22Publications
7H-index
137Citations
Publications 22
Newest
Objective: Copper (Cu) is essential micronutrient, and its dysregulation is implicated in aortic aneurysm (AA) development. The Cu exporter ATP7A (copper-transporting P-type ATPase/Menkes ATPase) d...
#1Varadarajan Sudhahar (Georgia Regents University)H-Index: 2
#2Archita Das (Georgia Regents University)H-Index: 7
Last.Tohru Fukai (Georgia Regents University)H-Index: 3
view all 16 authors...
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#1Archita Das (Georgia Regents University)H-Index: 7
#2Varadarajan Sudhahar (Georgia Regents University)H-Index: 2
Last.Tohru Fukai (Georgia Regents University)H-Index: 3
view all 4 authors...
NADPH oxidase (NOX)-derived reactive oxygen species (ROS) and copper (Cu), an essential micronutrient, have been implicated in vascular inflammatory diseases. We reported that in proinflammatory cy...
Source
#1Archita DasH-Index: 7
Last.Masuko Ushio-FukaiH-Index: 45
view all 9 authors...
Introduction: Reactive oxygen species (ROS) and copper (Cu), an essential micronutrient, play an important role in angiogenesis; however, their relationship in VEGF-induced angiogenesis in endothel...
#1Young-Mee Kim (Georgia Regents University)H-Index: 2
#2Seock-Won Youn (Georgia Regents University)H-Index: 2
Last.Masuko Ushio-Fukai (Georgia Regents University)H-Index: 2
view all 16 authors...
Summary Mitochondrial dynamics are tightly controlled by fusion and fission, and their dysregulation and excess reactive oxygen species (ROS) contribute to endothelial cell (EC) dysfunction. How redox signals regulate coupling between mitochondrial dynamics and endothelial (dys)function remains unknown. Here, we identify protein disulfide isomerase A1 (PDIA1) as a thiol reductase for the mitochondrial fission protein Drp1. A biotin-labeled Cys-OH trapping probe and rescue experiments reveal that...
13 CitationsSource
#1Archita DasH-Index: 7
#2Youngmee KimH-Index: 38
Last.Masuko Ushio-FukaiH-Index: 45
view all 7 authors...
Background: Reactive oxygen species (ROS) and copper (Cu), an essential micronutrient, play an important role in angiogenesis with unknown mechanisms. Cysteine sulfenic acid (Cys-OH) formation is i...
#1Sudhahar Varadarajan (UIC: University of Illinois at Chicago)H-Index: 3
#2Archita Das (UIC: University of Illinois at Chicago)H-Index: 7
Last.Tohru Fukai (UIC: University of Illinois at Chicago)H-Index: 40
view all 9 authors...
Introduction: Disturbed flow (d-flow) including oscillatory shear (OS) causes endothelial dysfunction, leading to atherosclerosis. SUMOylation alters localization and transcriptional activity of protein. Copper (Cu), an essential micronutrient, plays a pivotal role in inflammation. We recently reported that Cu transport protein, antioxidant 1 (Atox1) functions not only as Cu chaperone to activate secretory Cu enzymes via Cu exporter ATP7A, but also as Cu-dependent transcription factor for inflam...
#1Archita DasH-Index: 7
Last.Tohru FukaiH-Index: 40
view all 7 authors...
Background: Copper (Cu) is implicated in inflammation and atherosclerosis with unknown mechanism. Cu chaperone Atox1 is recently discovered to function as a Cu-dependent transcription factor for NADPH oxidase organizer p47phox to promote ROS-dependent inflammatory gene expression in endothelial cells (ECs). However, mechanism of Atox1 nuclear translocation and its role in atherosclerosis remain unknown. SUMOylation can alter localization and transcriptional activity of proteins. Hypothesis: SUMO...
#1Archita Das (UIC: University of Illinois at Chicago)H-Index: 7
#2Varadarajan Sudhahar (UIC: University of Illinois at Chicago)H-Index: 14
Last.Tohru Fukai (UIC: University of Illinois at Chicago)H-Index: 40
view all 12 authors...
Copper (Cu), an essential nutrient, promotes wound healing, however, target of Cu action and underlying mechanisms remain elusive. Cu chaperone Antioxidant-1 (Atox1) in the cytosol supplies Cu to the secretory enzymes such as lysyl oxidase (LOX), while Atox1 in the nucleus functions as a Cu-dependent transcription factor. Using mouse cutaneous wound healing model, here we show that Cu content (by X-ray Fluorescence Microscopy) and nuclear Atox1 are increased after wounding, and that wound healin...
15 CitationsSource
#1Gin Fu Chen (UIC: University of Illinois at Chicago)H-Index: 7
#2Varadarajan Sudhahar (UIC: University of Illinois at Chicago)H-Index: 14
Last.Tohru Fukai (UIC: University of Illinois at Chicago)H-Index: 40
view all 18 authors...
Copper (Cu), an essential micronutrient, plays a fundamental role in inflammation and angiogenesis; however, its precise mechanism remains undefined. Here we uncover a novel role of Cu transport protein Antioxidant-1 (Atox1), which is originally appreciated as a Cu chaperone and recently discovered as a Cu-dependent transcription factor, in inflammatory neovascularization. Atox1 expression is upregulated in patients and mice with critical limb ischemia. Atox1-deficient mice show impaired limb pe...
23 CitationsSource
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