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Jakub Siudut
Jagiellonian University Medical College
FibrinolysisFibrinBiochemistryDiabetes mellitusMedicine
14Publications
5H-index
58Citations
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Publications 15
Newest
#1Agata Hanna Bryk (Jagiellonian University Medical College)H-Index: 3
#2Jakub Siudut (Jagiellonian University Medical College)H-Index: 5
Last. Anetta Undas (Jagiellonian University Medical College)H-Index: 41
view all 7 authors...
Abstract Background Type 2 diabetes mellitus (T2DM) is associated with hypofibrinolysis and increased factor XIII-mediated α2-antiplasmin incorporation into the fibrin clot. It is unclear whether there are sex-related differences in α2-antiplasmin incorporation in relation to impaired clot lysis in T2DM. Aim We investigated α2-antiplasmin incorporation into fibrin clots as a determinant of clot lysability in patients of both sexes with T2DM. Methods In a group of 113 T2DM patients, 54 (47.8%) of...
1 CitationsSource
#1Maciej Polak (Jagiellonian University Medical College)H-Index: 4
#2Jakub Siudut (Jagiellonian University Medical College)H-Index: 5
Last. Anetta Undas (Jagiellonian University Medical College)H-Index: 41
view all 4 authors...
Venous ulcers are the most severe manifestation of post-thrombotic syndrome (PTS). We have previously demonstrated that formation of compact fibrin clots resistant to lysis is observed in patients following deep-vein thrombosis (DVT) who developed PTS. The current study investigated whether unfavourable fibrin clot properties can predict post-thrombotic venous ulcers. In a cohort study on 186 consecutive patients following DVT, we determined plasma fibrin clot characteristics, including clot per...
Source
#1M KopytekH-Index: 2
#2Michal ZabczykH-Index: 5
Last. Anetta UndasH-Index: 41
view all 9 authors...
Source
#1Joanna Natorska (Jagiellonian University Medical College)H-Index: 4
#2Jakub Siudut (Jagiellonian University Medical College)H-Index: 5
Last. Anetta Undas (Jagiellonian University Medical College)H-Index: 41
view all 5 authors...
Source
#1Grzegorz Gajos (Jagiellonian University Medical College)H-Index: 10
#2Aleksander Siniarski (Jagiellonian University Medical College)H-Index: 3
Last. Anetta Undas (Jagiellonian University Medical College)H-Index: 41
view all 9 authors...
Background Little is known about factors that affect the composition of contracted blood clots in specific diseases. We investigated the content of polyhedral erythrocytes (polyhedrocytes) formed in blood clots and its determinants in type 2 diabetes (T2D) patients.
2 CitationsSource
#1Jakub Siudut (Jagiellonian University Medical College)H-Index: 5
#2Joanna Natorska (Jagiellonian University Medical College)H-Index: 4
Last. Anetta Undas (Jagiellonian University Medical College)H-Index: 41
view all 7 authors...
Abstract Introduction Venous thromboembolism (VTE) is associated with hypofibrinolysis. Its mechanisms are poorly understood. We investigated plasminogen-fibrin interaction and its association with fibrinolytic capacity and protein oxidation/carbonylation in VTE patients. Materials and methods Plasma-purified plasminogen conversion to plasmin and surface plasmon resonance employed for plasminogen-fibrin interactions were individually evaluated in all healthy controls and non-anticoagulated patie...
1 CitationsSource
#1Aneta Stachowicz (MPG: Max Planck Society)H-Index: 3
#2Jakub Siudut (Jagiellonian University Medical College)H-Index: 5
Last. Jacek R. Wiśniewski (MPG: Max Planck Society)H-Index: 25
view all 7 authors...
It is well known that fibrin network binds a large variety of proteins, including inhibitors and activators of fibrinolysis, which may affect clot properties, such as stability and susceptibility to fibrinolysis. Specific plasma clot composition differs between individuals and may change in disease states. However, the plasma clot proteome has not yet been in-depth analyzed, mainly due to technical difficulty related to the presence of a highly abundant protein—fibrinogen and fibrin that forms a...
5 CitationsSource
#1A. Janion-SadowskaH-Index: 1
#2Joanna NatorskaH-Index: 4
Last. Anetta UndasH-Index: 41
view all 6 authors...
We sought to investigate whether the G20210A prothrombin mutation modifies plasma fibrin clot properties in patients after venous thromboembolism (VTE) and how rivaroxaban treatment affects these alterations. We studied 34 prothrombin mutation heterozygous carriers and sex- and age-matched 34 non-carriers, all at least three months since the first VTE episode, before and during treatment with rivaroxaban. Clot permeability (Ks) and clot lysis time (CLT) with or without elimination of thrombin ac...
4 CitationsSource
#1Jan P. BembenekH-Index: 7
#2Maciej NiewadaH-Index: 17
Last. Anetta UndasH-Index: 41
view all 6 authors...
Fibrin clot properties in acute ischaemic stroke (AIS) are unfavourably altered, including faster formation of denser and poorly lysable fibre networks. We investigated clot properties in AIS patients treated with recombinant tissue plasminogen activator (rtPA) and their impact on clinical outcome. In 74 consecutive AIS patients eligible for rtPA treatment, we assessed ex vivo plasma fibrin clot formation, permeability (Ks), and rtPA-induced lysis, along with peak thrombin generation, fibrinolys...
7 CitationsSource
OBJECTIVES: Eosinophilic granulomatosis with polyangiitis (EGPA) is associated with an inflammation and the presence of antineutrophil cytoplasmic antibodies (ANCA). Thus, we investigated the impact of ANCAs and eosinophilic inflammation on neutrophil activation and extracellular traps (NETs) formation. METHODS: We recruited 29 patients in the remission of EGPA (17 ANCA-negative and 12 ANCA-positive, including 7 p-ANCA-positive and 5 c-ANCA-positive patients). Healthy donors' neutrophils were st...
2 Citations
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