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Flemming Dela
University of Copenhagen
EndocrinologyInsulinSkeletal muscleDiabetes mellitusMedicine
304Publications
47H-index
8,572Citations
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Publications 301
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#1Jacob Frandsen (UCPH: University of Copenhagen)H-Index: 2
#2Nina Pistoljevic (UCPH: University of Copenhagen)
Last. Jørn Wulff Helge (UCPH: University of Copenhagen)H-Index: 41
view all 8 authors...
Female sex hormones fluctuate in a predictable manner throughout the menstrual cycle in eumenorrheic women. In studies conducted in both animal and humans, estrogen and progesterone have been found...
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#2Lærke S. GasbjergH-Index: 8
Last. Filip K. KnopH-Index: 35
view all 12 authors...
OBJECTIVE Dual incretin receptor agonists in clinical development have shown reductions in body weight and hemoglobin A1c (HbA1c) in patients with type 2 diabetes, but the impact of glucose-dependent insulinotropic polypeptide (GIP) receptor activation remains unclear. Here, we evaluated the effects of high-dose exogenous GIP on energy intake, energy expenditure, plasma glucose, and glucose-regulating hormones in patients with type 2 diabetes treated with a long-acting glucagon-like peptide 1 re...
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#1Jacob Frandsen (UCPH: University of Copenhagen)H-Index: 2
#2Thomas N Beck (UCPH: University of Copenhagen)H-Index: 1
Last. Jørn Wulff Helge (UCPH: University of Copenhagen)H-Index: 41
view all 6 authors...
An attenuated ability to appropriately oxidize fat (metabolic inflexibility) has been associated with the development of obesity and type 2 diabetes. Previous studies have found that regula...
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#1Maria Hansen (UCPH: University of Copenhagen)H-Index: 3
#2Anja Birk Kuhlman (UCPH: University of Copenhagen)H-Index: 4
Last. Flemming Dela (UCPH: University of Copenhagen)H-Index: 47
view all 10 authors...
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#1Paul L. Greenhaff (NIHR: National Institute for Health Research)H-Index: 54
#2Joanne Mallinson (NIHR: National Institute for Health Research)
Last. Flemming Dela (UCPH: University of Copenhagen)H-Index: 47
view all 3 authors...
Animal models of overt statin myopathy reveal clear negative effects on muscle protein and carbohydrate metabolism, which appear to be linked to changes in Akt/FOXO signalling. Forcibly increasing muscle carbohydrate flux under these conditions by pharmacological means blocks statin myopathy. Human volunteer research has delivered less definitive mechanistic insight of the aetiology of statin-related metabolic dysregulation, with little evidence of profound changes in muscle protein and carbohyd...
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#1Karoline Maise Chrøis (UCPH: University of Copenhagen)H-Index: 1
#2Tine Lovsø Dohlmann (UCPH: University of Copenhagen)H-Index: 4
Last. Steen Larsen (UCPH: University of Copenhagen)H-Index: 28
view all 7 authors...
AbstractIntroduction: High intensity interval training (HIIT) has shown to be as effective as moderate intensity endurance training to improve metabolic health. However, the current knowledge on th...
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#1Karoline Maise Chrøis (UCPH: University of Copenhagen)H-Index: 1
#2Steen Larsen (UCPH: University of Copenhagen)H-Index: 28
Last. Flemming Dela (UCPH: University of Copenhagen)H-Index: 47
view all 7 authors...
1 CitationsSource
#1Ryosuke Shirakawa (Hokkaido University)H-Index: 1
#2Takashi Yokota (Hokkaido University)H-Index: 25
Last. Toshihisa Anzai (Hokkaido University)H-Index: 34
view all 15 authors...
Systemic oxidative stress plays a key role in the development of chronic heart failure (CHF). We tested the hypothesis that mitochondrial reactive oxygen species (ROS) generation in circulating peripheral blood mononuclear cells (PBMCs) contributes to CHF progression. A total of 31 patients who had a history of hospital admission due to worsening HF were enrolled and grouped as having either mild CHF defined as New York Heart Association (NYHA) functional class I-II or moderate-to-severe CHF def...
2 CitationsSource
#1Anja Birk Kuhlman (UCPH: University of Copenhagen)H-Index: 4
#2Thomas Morville (UCPH: University of Copenhagen)H-Index: 3
Last. Flemming Dela (UCPH: University of Copenhagen)H-Index: 47
view all 7 authors...
Simvastatin is a cholesterol-lowering drug that is prescribed to lower the risk of cardiovascular disease following high levels of blood cholesterol. There is a possible risk of new onset diabetes mellitus with statin treatment but the mechanisms behind are unknown. Coenzyme Q10 (CoQ10) supplementation has been found to improve glucose homeostasis in various patient populations and may increase muscle GLUT4 content. Our aim was to investigate whether eight weeks of CoQ10 supplementation can impr...
1 CitationsSource
#1Marie Louise Johansen (UCPH: University of Copenhagen)H-Index: 2
#2Morten Schou (UCPH: University of Copenhagen)H-Index: 22
Last. Caroline Kistorp (UCPH: University of Copenhagen)H-Index: 4
view all 9 authors...
Abstract Aim Natriuretic peptides (NPs) have emerged as important regulators of lipid metabolism. Reduced levels of NPs are reported in obesity and in patients with type 2 diabetes (T2D). This NP deficiency may affect their ectopic fat distribution and lead to high risk of non-alcoholic fatty liver disease (NAFLD). Methods In this cross-sectional study, the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and liver fat content was quantified using 1H-magnetic resonance s...
2 CitationsSource
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