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Saman Rezazadeh
Libin Cardiovascular Institute of Alberta
10Publications
1H-index
4Citations
Publications 10
Newest
#1Andreas Brodehl (Libin Cardiovascular Institute of Alberta)H-Index: 8
#2Saman Rezazadeh (Libin Cardiovascular Institute of Alberta)H-Index: 1
Last.Amy L. Stiegler (Yale University)H-Index: 10
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Arrhythmogenic cardiomyopathy is a genetic heart muscle disorder characterized by fibro-fatty replacement of cardiomyocytes leading to life-threatening ventricular arrhythmias, heart failure, and sudden cardiac death. Mutations in genes encoding cardiac junctional proteins are known to cause about half of cases, while remaining genetic causes are unknown. Using exome sequencing, we identified 2 missense variants (p.H33N and p.H77Y) that were predicted to be damaging in the integrin-linked kinase...
#1Robert J.H. Miller (Libin Cardiovascular Institute of Alberta)H-Index: 3
#2Derek S. Chew (Libin Cardiovascular Institute of Alberta)H-Index: 4
Last.F. Russell Quinn (Libin Cardiovascular Institute of Alberta)H-Index: 7
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Abstract Atrial fibrillation and atrial flutter (AF/AFL) are associated with an increased risk of stroke and systemic embolism. However, many patients are not started on guideline-recommended oral anticoagulation (OAC). We determined factors associated with OAC initiation in eligible patients presenting to the emergency department (ED). This retrospective cohort included patients with electrocardiogram (ECG) documented AF/AFL presenting to 4 urban EDs in 2015. Presenting diagnosis, admission sta...
#1Saman Rezazadeh (Libin Cardiovascular Institute of Alberta)H-Index: 1
#2Robert J.H. Miller (Libin Cardiovascular Institute of Alberta)H-Index: 3
Last.Derek S. Chew (Libin Cardiovascular Institute of Alberta)H-Index: 4
view all 3 authors...
#1Derek S. Chew (Libin Cardiovascular Institute of Alberta)H-Index: 4
#2Saman Rezazadeh (Libin Cardiovascular Institute of Alberta)H-Index: 1
Last.Robert J.H. Miller (Libin Cardiovascular Institute of Alberta)H-Index: 3
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#1Saman Rezazadeh (Libin Cardiovascular Institute of Alberta)H-Index: 1
#2Henry J. Duff (Libin Cardiovascular Institute of Alberta)H-Index: 40
Abstract Bradyarrhythmia is a common clinical presentation. Although the majority of cases are acquired, genetic screening of families with bradyarrhythmia has led to the discovery of a growing number of causative hereditary mutations. These mutations can interfere with any of the steps required for the occurrence of each cardiac cycle, including generation of an action potential in the sinoatrial node, successful exit of the action potential from the node, propagation of the action potential th...
#1Saman Rezazadeh (Libin Cardiovascular Institute of Alberta)H-Index: 1
#2Jiqing Guo (Libin Cardiovascular Institute of Alberta)H-Index: 14
Last.Brenda Gerull (Libin Cardiovascular Institute of Alberta)H-Index: 2
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Abstract Andersen-Tawil syndrome (ATS) is caused by mutations in KCNJ2 (Kir2.1). It remains unclear whether dilated cardiomyopathy (DCM) is a primary feature of ATS. We studied a proband with typical physical features of ATS plus DCM and moderate to severe left ventricular dysfunction (left ventricular ejection fraction = 30.5%). Genetic screening revealed a novel mutation in Kir2.1 (c.665T>C, p.L222S). Functional studies showed that this mutation reduced ionic currents in a dominant-negative ma...
#1Saman Rezazadeh (Libin Cardiovascular Institute of Alberta)H-Index: 1
#2Henry J. Duff (Libin Cardiovascular Institute of Alberta)H-Index: 40
Sudden cardiac death secondary to drug-induced long QT syndrome is a major safety concern and has led to withdrawal of several high-profile drugs, such as cisapride and astemizole, from the market. Although these drugs have different chemical structures, they all block the rapid delayed rectifier K+ current ( I Kr) with high potency. The hERG channel (Kv11.1) encoded by the hERG gene is responsible for this current. This channel has a high affinity for wide spectrum of compounds compared with ot...
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