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Luciana Moreira
University of Porto
TransthyretinErythropoietinAmyloidosisMedicineBiology
10Publications
3H-index
23Citations
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Publications 10
Newest
#1Neda StjepanovicH-Index: 1
#2Luciana MoreiraH-Index: 3
Last. E. MartinelliH-Index: 1
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3 CitationsSource
#1Luciana Moreira (University of Porto)H-Index: 3
#2A.J. Duarte (University of Porto)
Last. O. Amaral (University of Porto)H-Index: 5
view all 4 authors...
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) were found as an immune adaptive mechanism in bacteria and quickly were applied to various fields as a promising tool for gene editing. Lysosomal storage diseases (LSDs) are a group of metabolic disorders caused by defects in lysosomal proteins leading to accumulation of undigested macromolecules within the cells. The lack of good in vitro models hinders research of the pathophysiologic mechanisms and the development of new thera...
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In order to delineate a better approach to functional studies, we have selected 23 missense mutations distributed in different domains of two lysosomal enzymes, to be studied by in silico analysis. In silico analysis of mutations relies on computational modeling to predict their effects. Various computational platforms are currently available to check the probable causality of mutations encountered in patients at the protein and at the RNA levels. In this work we used four different platforms fr...
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#1Ana Joana DuarteH-Index: 3
#2Luciana MoreiraH-Index: 3
Last. Olga AmaralH-Index: 9
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LM, DR were grantees of FCT: PTDC/BIM-MEC/4762/2014 (2016-) and AJD was recipient of a PhD grant from FCT SFRH/BD/118009/2016.
#1Luciana Moreira (University of Porto)H-Index: 3
#2João Melo Beirão (University of Porto)H-Index: 4
Last. Paulo Costa (University of Porto)H-Index: 24
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AbstractFamilial amyloidotic polyneuropathy, ATTRV30M (p. TTRV50M) amyloidosis, is a neurodegenerative disease characterized by systemic extracellular amyloid deposition of a mutant transthyretin, TTR V30M. Anemia, with low erythropoietin (EPO) levels and spared kidney function, affects about 25% of symptomatic patients, suggesting a blockage of EPO-producing cells. Early non-fibrillar TTR aggregates are highly cytotoxic, inducing oxidative stress, the expression of apoptosis-related molecules a...
4 CitationsSource
#1Isabel Tavares (University of Porto)H-Index: 6
#2Raquel Vaz (University of Porto)H-Index: 3
Last. Luísa Lobato (University of Porto)H-Index: 8
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3 Citations
#1João Melo BeirãoH-Index: 4
#2Luciana MoreiraH-Index: 3
Last. Idalina BeirãoH-Index: 11
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Purpose Glaucoma is the leading cause of irreversible blindness in familial amyloidotic polyneuropathy (FAP) patients. Erythropoietin (EPO) is a cytokine that has been shown to play a role in neuroprotection and is endogenously produced in the eye. EPO levels in the aqueous humor are increased in eyes with glaucoma. In this study, we evaluated the EPO concentration in the aqueous humor of FAP and non-FAP patients, with and without glaucoma.
4 Citations
#1Olga AmaralH-Index: 9
#2Sandra AlvesH-Index: 2
Last. Liliana MatosH-Index: 2
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"The Dana Foundation brain awareness week" facultou algum material didatico; a participacao de bolseiros e alunos foi possivel atraves das bolsas concedidas pela FCT (Fundacao para a Ciencia e a Tecnologia).
#1Isabel TavaresH-Index: 6
#2L. LobatoH-Index: 7
Last. Paulo CostaH-Index: 24
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3 CitationsSource
#1Idalina BeirãoH-Index: 11
#2Luciana MoreiraH-Index: 3
Last. Paulo Pinho CostaH-Index: 1
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Background/Aim: The kidney is the major site of erythropoietin production. Many efforts have been made to identify renal erythropoietin-producing cells. Previous studies showed conflicting results, but the predominant localization reported was the peri-tubular interstitial and tubular epithelial cells. This study was conducted to identify the erythropoietin-producing cells in renal biopsies from 10 cadaveric donors and 45 patients with familial amyloidosis ATTR V30M, thirteen of them with anemia...
8 CitationsSource
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