Match!
Bianca Besteher
University of Jena
PsychiatryPsychologyGyrificationAnxietySchizophrenia
19Publications
4H-index
40Citations
What is this?
Publications 21
Newest
#1Igor NenadicH-Index: 23
Last. Christian GaserH-Index: 61
view all 5 authors...
Source
#1Bianca BesteherH-Index: 4
#2Paolo Brambilla (University of Milan)H-Index: 70
Last. Igor Nenadic (University of Marburg)H-Index: 23
view all 3 authors...
Abstract Twin studies in schizophrenia have been crucial in establishing estimates for the heritability and thus providing evidence for a genetic component in this disorder. Recent years have seen the application of the twin study paradigm to both putative intermediate phenotypes and biomarkers of disease as well as a diversification of its use in schizophrenia research. This review addressed studies of brain structure (T1 morphometry) and cognition in schizophrenia using twin study designs. We ...
Source
Abstract Tinnitus describes the perception of a sound without external source and is characterized by high comorbidity, e.g. depression. In many studies, tinnitus patients were compared to healthy controls while a comorbid psychiatric diagnosis was an exclusion criterion. Consequently, patients with severe tinnitus and psychiatric comorbidity were often neglected. In the current study, we tried to fill this gap and compared four groups including two control groups: (1) chronic tinnitus patients ...
Source
#1Robert SpalthoffH-Index: 3
#2Franziska Degenhardt (University of Bonn)H-Index: 32
Last. Igor Nenadic (Phillips University)H-Index: 23
view all 9 authors...
Abstract We tested whether a polygenic risk score integrating the effects of genes affecting neurodevelopment is associated to brain structural variation in healthy subjects. We acquired magnetic resonance imaging and genetic data of 167 healthy adults and computed a neurodevelopmental polygenic risk score (nPRS). We correlated the nPRS with local gyrification, cortical thickness and grey matter density and explored effects of single nucleotide polymorphisms included in the score. We did not fin...
Source
#1Bianca BesteherH-Index: 4
#2Christian GaserH-Index: 61
Last. Igor Nenadic (University of Marburg)H-Index: 25
view all 3 authors...
Abstract Molecular biological findings indicate that affective disorders are associated with processes akin to accelerated aging of the brain. The use of the BrainAGE (brain age estimation gap) framework allows machine-learning based detection of a gap between age estimated from high-resolution MRI scans an chronological age, and thus an indicator of systems-level accelerated aging. We analysed 3T high-resolution structural MRI scans in 38 major depression patients (without co-morbid axis I or I...
Source
#1Bianca BesteherH-Index: 4
#2Christian GaserH-Index: 61
Last. Igor Nenadic (University of Marburg)H-Index: 25
view all 6 authors...
Abstract Chronic tinnitus has been associated with brain structural changes in both the auditory system as well as limbic system. While there is considerable inconsistency across brain structural findings, growing evidence suggests that distress and other non-auditory symptoms modulate effects. In this study we addressed this issue, testing the hypothesis that limbic changes in tinnitus relate to both disease-related distress as well as co-morbid psychopathology. We obtained high-resolution stru...
Source
#1Bianca BesteherH-Index: 4
#2Christian GaserH-Index: 61
Last. Igor Nenadic (University of Marburg)H-Index: 25
view all 3 authors...
Abstract Impulsivity as a trait modulates a range of cognitive functions, e.g. planning, decision-making, or response inhibition. Recent behavioural and psychometric findings challenge both the neurobiological models as well as the conceptualisation of psychometric measures of impulsivity. In the present study, we aimed to test the association of brain structure with the Barratt Impulsiveness Scale (BIS-11), a commonly applied self-rating instrument for impulsivity, using both the classical thre...
Source
#1Bianca BesteherH-Index: 4
#2Christian GaserH-Index: 61
Last. Igor NenadicH-Index: 23
view all 3 authors...
Source
#1Bianca BesteherH-Index: 4
#2Letizia Squarcina (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 7
Last. Igor Nenadic (University of Marburg)H-Index: 25
view all 7 authors...
Case-control studies in major depression have established patterns of regional grey matter loss, including the hippocampus, which might show state-related effects dependent on disease stage. However, there is still limited knowledge on compensation effects that might occur in people resilient to depression showing only subclinical symptoms. We used voxel-based morphometry on a multi-centre data set of 409 healthy non-clinical subjects to test the hypothesis that local hippocampal volume would be...
Source
#1Mathilde Antoniades ('KCL': King's College London)H-Index: 3
#2Alex Fornito (Monash University)H-Index: 61
Last. Gemma Modinos ('KCL': King's College London)H-Index: 20
view all 27 authors...
Source
123