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Łukasz Kubik
Gdańsk Medical University
Analytical chemistryChemistryPartition coefficientChromatographyDissociation constant
13Publications
9H-index
127Citations
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Publications 13
Newest
#1Łukasz Kubik (Gdańsk Medical University)H-Index: 9
#2Roman Kaliszan (Gdańsk Medical University)H-Index: 48
Last. Paweł Wiczling (Gdańsk Medical University)H-Index: 18
view all 3 authors...
The objective of this work was to develop a multilevel (hierarchical) model based on isocratic-reversed-phase-high-performance-chromatographic data collected in methanol and acetonitrile for 58 chemical compounds. Such a multilevel model is a regression model of the analyte-specific chromatographic measurements, in which all the regression parameters are given a probability model. It is a fundamentally different approach from the most common approach, where parameters are separately estimated fo...
1 CitationsSource
#1Katarzyna Mioduszewska (University of Gdańsk)H-Index: 7
#2Joanna Dołżonek (University of Gdańsk)H-Index: 3
Last. Anna Białk-Bielińska (University of Gdańsk)H-Index: 18
view all 10 authors...
Abstract We present a review of the available literature concerning pKa values and methods for the determination of selected anticancer drugs as well as the most up-to-date knowledge on their different ionic forms depending on solution pH. Additionally, to clarify the existing state of knowledge we have presented an overview on the obtained pKa values with the use of experimental and computational methods. As a result, we have demonstrated and proposed acid-base equilibria of cyclophosphamide (C...
9 CitationsSource
#1Łukasz KubikH-Index: 9
#2Paweł WiczlingH-Index: 18
Last. Roman KaliszanH-Index: 48
view all 3 authors...
1 CitationsSource
#1Joanna Raczak-Gutknecht (Gdańsk Medical University)H-Index: 3
#2Antoni Nasal (Gdańsk Medical University)H-Index: 13
Last. Roman Kaliszan (Gdańsk Medical University)H-Index: 48
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Abstract Imidazol(in)e derivatives, having the chemical structure similar to clonidine, exert diverse pharmacological activities connected with their interactions with alpha2-adrenergic receptors, e.g . hypotension, bradycardia, sedation as well as antinociceptive, anxiolytic, antiarrhythmic, muscle relaxant and mydriatic effects. The mechanism of pupillary dilation observed after systemic administration of imidazol(in)es to rats, mice and cats depends on the stimulation of postsynaptic alpha2-a...
2 CitationsSource
#1Łukasz Kubik (Gdańsk Medical University)H-Index: 9
#2Paweł Wiczling (Gdańsk Medical University)H-Index: 18
Abstract The aim of this work was to develop mathematical models relating the hydrophobicity and dissociation constant of an analyte with its structure, which would be useful in predicting analyte retention times in reversed-phase liquid chromatography. For that purpose a large and diverse group of 115 drugs was used to build three QSRR models combining retention-related parameters (log k w —chromatographic measure of hydrophobicity, S—slope factor from Snyder-Soczewinski equation, and p K a ) w...
9 CitationsSource
#1Paweł Wiczling (Gdańsk Medical University)H-Index: 18
#2Łukasz Kubik (Gdańsk Medical University)H-Index: 9
Last. Roman Kaliszan (Gdańsk Medical University)H-Index: 48
view all 3 authors...
The pH of a mobile phase is one of the most important parameters affecting retention of ionic analytes in reversed phase high-performance liquid chromatography (RP-HPLC). RP-HPLC and hydrophilic interaction liquid chromatography (HILIC) can be used as a convenient tool for the analysis of ionizable analytes. The ionic analyte contains one or more acidic or basic functional groups in its molecular structure. Acidic compounds lose a proton as pH increases, whereas bases gain a proton as pH decreas...
Source
#1Łukasz Kubik (Gdańsk Medical University)H-Index: 9
#2Wiktoria Struck-Lewicka (Gdańsk Medical University)H-Index: 9
Last. Paweł Wiczling (Gdańsk Medical University)H-Index: 18
view all 4 authors...
Fast and reliable methods for the determination of hydrophobicity and acidity are desired in pre-clinical drug development phases to eliminate compounds with poor pharmacokinetic properties. Reversed-phase high-performance liquid chromatography (RP HPLC) coupled with time-of-flight mass spectrometry (RP HPLC–ESI-TOF–MS) is a convenient technique for that purpose. In this work we determined the chromatographic measure of hydrophobicity (log kw) and dissociation constant (pKa) simultaneously for a...
11 CitationsSource
#1Flaviana Di LorenzoH-Index: 10
#2Łukasz Kubik (Gdańsk Medical University)H-Index: 9
Last. Antonio MolinaroH-Index: 33
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Abstract Lung infection by Burkholderia species, in particular Burkholderia cenocepacia, accelerates tissue damage and increases post-lung transplant mortality in cystic fibrosis patients. Host-microbe interplay largely depends on interactions between pathogen-specific molecules and innate immune receptors such as Toll-like receptor 4 (TLR4), which recognizes the lipid A moiety of the bacterial lipopolysaccharide (LPS). The human TLR4·myeloid differentiation factor 2 (MD-2) LPS receptor complex ...
20 CitationsSource
#1Paweł WiczlingH-Index: 18
#2Łukasz KubikH-Index: 9
Last. Roman KaliszanH-Index: 48
view all 3 authors...
The aim of this work was to develop a nonlinear mixed-effect chromatographic model able to describe the retention times of weak acids and bases in all possible combinations of organic modifier content and mobile-phase pH. Further, we aimed to identify the influence of basic covariates, like lipophilicity (log P), dissociation constant (pKa), and polar surface area (PSA), on the intercompound variability of chromatographic parameters. Lastly, we aimed to propose the optimal limited experimental d...
10 CitationsSource
#1Emilia Daghir-Wojtkowiak (Gdańsk Medical University)H-Index: 4
#2Paweł Wiczling (Gdańsk Medical University)H-Index: 18
Last. Michał J. Markuszewski (Gdańsk Medical University)H-Index: 21
view all 8 authors...
Abstract The objective of this study was to model the retention of nucleosides and pterins in hydrophilic interaction liquid chromatography (HILIC) via QSRR-based approach. Two home-made (Amino-P-C18, Amino-P-C10) and one commercial (IAM.PC.DD2) HILIC stationary phases were considered. Logarithm of retention factor at 5% of acetonitrile (log k ACN ) along with descriptors obtained for 16 nucleosides and 11 pterins were used to develop QSRR models. We used and compared the predictive performance ...
13 CitationsSource
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