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Kenichi Kobayashi
Meiji Pharmaceutical University
Darzens reactionOrganic chemistryChemistryTotal synthesisPhotochemistry
20Publications
5H-index
73Citations
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Publications 20
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#1Kenichi KobayashiH-Index: 5
#2Risako KunimuraH-Index: 2
Last. Hiroshi KogenH-Index: 18
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Paraphaeosphaeride C is a demethoxy derivative of phaeosphaeride A and exhibits STAT3 inhibitory activity. Our previous papers reported the total synthesis of phaeosphaeride A using a diastereoselective vinyl anion aldol reaction as the key step to construct the dihydropyran ring. In this work, the first total synthesis of the proposed structure of paraphaeosphaeride C was achieved via a similar synthetic strategy. The synthetic compound was characterized through extensive nuclear magnetic reson...
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#1Kenichi Kobayashi (Meiji Pharmaceutical University)H-Index: 5
#2Kosaku Tanaka (Meiji Pharmaceutical University)H-Index: 3
Last. Hiroshi Kogen (Meiji Pharmaceutical University)H-Index: 18
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A catalytic asymmetric intramolecular Darzens reaction of 2-halomalonate derivatives was developed for the enantioselective preparation of chiral building blocks for epoxide-containing natural prod...
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#1Momoko Suzuki (Meiji Pharmaceutical University)H-Index: 1
#2Shougo Hashimoto (Meiji Pharmaceutical University)
Last. Kenichi Kobayashi (Meiji Pharmaceutical University)H-Index: 5
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Epothilone D, a microtubule-stabilizing macrolide, is an attractive synthetic target molecule as a potential anti-cancer drug candidate. As part of our ongoing synthetic studies of this natural pro...
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#1Kosaku Tanaka (Meiji Pharmaceutical University)H-Index: 3
#2Yusuke Honma (Meiji Pharmaceutical University)H-Index: 1
Last. Hiroshi Kogen (Meiji Pharmaceutical University)H-Index: 18
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Abstract The relative and absolute configurations of L-755,807 were established through total synthesis. All four possible stereoisomers were prepared via a convergent synthetic strategy, including a novel diastereoselective Darzens reaction of an α-alkoxy aldehyde with di- tert -butyl bromomalonate, an E -selective Horner–Wadsworth–Emmons reaction, and late-stage coupling of the ring and side-chain segments. Additionally, biological evaluation of the synthesized compounds revealed their potent ...
3 CitationsSource
#1Hiroshi KogenH-Index: 18
#2Kenichi KobayashiH-Index: 5
Last. Momoko SuzukiH-Index: 1
view all 8 authors...
Source
#1Kenichi KobayashiH-Index: 5
#2Hiroshi KogenH-Index: 18
Last. Momoko SuzukiH-Index: 1
view all 5 authors...
Source
#1Kenichi KobayashiH-Index: 5
#2Kosaku TanakaH-Index: 3
Last. Hiroshi KogenH-Index: 18
view all 3 authors...
This article reviews studies regarding the total synthesis of phaeosphaerides A and B, nitrogen-containing bicyclic natural products isolated from an endophytic fungus. Numerous synthetic efforts and an X-ray crystal structure analysis of phaeosphaeride A have enabled revision of its originally proposed structure. In addition, a successful protic acid-mediated transformation of phaeosphaeride A to phaeosphaeride B revealed the hypothetical biosynthesis of phaeosphaeride B from phaeosphaeride A. ...
3 CitationsSource
#1Hiroki Fukushima (Rikkyo University)
#2Daisuke Ikegami (Rikkyo University)
Last. Kenichi Kobayashi (Meiji Pharmaceutical University)H-Index: 5
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#1Kenichi KobayashiH-Index: 5
#2Risako KunimuraH-Index: 2
Last. Chiaki KurodaH-Index: 20
view all 7 authors...
The relative and absolute configurations of an oxygenated bisabolane natural product, isolated from Ligularia lankongensis, were determined by synthesis. All four possible stereoisomers and their tiglate analogues were synthesized from R-(−)-carvone, and their 1H and 13C NMR spectra were compared to establish the 6R,8S,10S configuration. The stereoselective synthesis of the natural product was also achieved, featuring Brown allylation, vanadium-catalyzed epoxidation, and the Mitsunobu reaction.
3 CitationsSource
#1Hiroshi KogenH-Index: 18
#2Kenichi KobayashiH-Index: 5
Last. Risako KunimuraH-Index: 2
view all 5 authors...
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