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Kenichi Kobayashi
Meiji Pharmaceutical University
16Publications
4H-index
47Citations
Publications 16
Newest
#1Momoko Suzuki (Meiji Pharmaceutical University)
#2Shougo Hashimoto (Meiji Pharmaceutical University)
Last.Kenichi Kobayashi (Meiji Pharmaceutical University)H-Index: 4
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Epothilone D, a microtubule-stabilizing macrolide, is an attractive synthetic target molecule as a potential anti-cancer drug candidate. As part of our ongoing synthetic studies of this natural pro...
#1Kosaku TanakaH-Index: 2
#2Kenichi Kobayashi (Meiji Pharmaceutical University)H-Index: 4
Last.Hiroshi Kogen (Meiji Pharmaceutical University)H-Index: 18
view all 3 authors...
#1Kosaku Tanaka (Meiji Pharmaceutical University)H-Index: 2
#2Yusuke Honma (Meiji Pharmaceutical University)
Last.Kenichi Kobayashi (Meiji Pharmaceutical University)H-Index: 4
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Abstract The relative and absolute configurations of L-755,807 were established through total synthesis. All four possible stereoisomers were prepared via a convergent synthetic strategy, including a novel diastereoselective Darzens reaction of an α-alkoxy aldehyde with di- tert -butyl bromomalonate, an E -selective Horner–Wadsworth–Emmons reaction, and late-stage coupling of the ring and side-chain segments. Additionally, biological evaluation of the synthesized compounds revealed their potent ...
#1Kenichi KobayashiH-Index: 4
#2Kosaku TanakaH-Index: 2
Last.Hiroshi KogenH-Index: 18
view all 3 authors...
This article reviews studies regarding the total synthesis of phaeosphaerides A and B, nitrogen-containing bicyclic natural products isolated from an endophytic fungus. Numerous synthetic efforts and an X-ray crystal structure analysis of phaeosphaeride A have enabled revision of its originally proposed structure. In addition, a successful protic acid-mediated transformation of phaeosphaeride A to phaeosphaeride B revealed the hypothetical biosynthesis of phaeosphaeride B from phaeosphaeride A. ...
The relative and absolute configurations of an oxygenated bisabolane natural product, isolated from Ligularia lankongensis, were determined by synthesis. All four possible stereoisomers and their tiglate analogues were synthesized from R-(−)-carvone, and their 1H and 13C NMR spectra were compared to establish the 6R,8S,10S configuration. The stereoselective synthesis of the natural product was also achieved, featuring Brown allylation, vanadium-catalyzed epoxidation, and the Mitsunobu reaction.
#1Kenichi Kobayashi (Meiji Pharmaceutical University)H-Index: 4
#2Kosaku Tanaka (Meiji Pharmaceutical University)H-Index: 2
Last.Hiroshi Kogen (Meiji Pharmaceutical University)H-Index: 18
view all 3 authors...
Abstract The Horner–Wadsworth–Emmons (HWE) reaction has become well established among existing methodologies for the highly stereoselective olefination of carbonyl compounds. The reliability of this reaction in terms of its robustness, high stereoselectivity, and broad substrate scope permit retrosynthetic disconnection of the olefin bond in α,β-unsaturated carbonyl intermediates in natural product synthesis. This review discusses recent applications of the HWE reaction in natural product synthe...
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