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E. B. de Sousa Fernandes Perna
Maastricht University
9Publications
4H-index
40Citations
Publications 9
Newest
#1Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
#2E. B. de Sousa Fernandes Perna (UM: Maastricht University)H-Index: 4
Last.Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
view all 7 authors...
ABSTRACTThe phenethylamine 4-fluoroamphetamine (4-FA) is a so-called novel psychoactive substance with a chemical structure resembling that of amphetamine and MDMA. Since 4-FA users report their subjective experience ranges between the effects induced by amphetamine and MDMA, and it is known that both substances can produce an altered state of consciousness, this study tests whether 4-FA induces a psychedelic state. A placebo-controlled two-way crossover study in 12 healthy poly-drug users was c...
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#1Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
#2R. de la Torre (UPF: Pompeu Fabra University)H-Index: 27
Last.Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
view all 7 authors...
MDMA exerts its main effects via the serotonergic system and the serotonin transporter. The gene coding for this transporter determines the expression rate of the transporter. Previously it was shown that healthy individuals with the short allelic variant (‘s-group’) of the 5-HTTLPR-polymorphism displayed more anxiety and negative mood, and had a lower transcriptional efficiency compared to individuals who are homozygous for the l-allele (‘l-group’). The present study aimed to investigate the ro...
1 CitationsSource
#1Kim P. C. Kuypers (UM: Maastricht University)H-Index: 21
#2E. B. de Sousa Fernandes Perna (UM: Maastricht University)H-Index: 4
Last.Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
view all 8 authors...
Background New psychoactive substances (NPS) are chemical analogues designed to mimic the effects of various classic recreational drugs of abuse including MDMA, LSD, and cannabis. NPS use is associated with concern about the acute and longer-term effects particular substances might have, with abuse and addiction as potential consequences. Impulsivity and sensitivity to the rewarding effects of drugs have been considered as risk factors for drug abuse. In light of the popularity of 4-fluoroamphet...
2 CitationsSource
#1E. B. de Sousa Fernandes Perna (UM: Maastricht University)H-Index: 4
#2Esther Papaseit (Autonomous University of Barcelona)H-Index: 12
Last.Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
view all 9 authors...
Recreational use of mephedrone, alone and in combination with alcohol, has increased over the past years. Pharmacological properties of mephedrone share similarities with methylenedioxymethamphetamine (MDMA), but its effect on neurocognitive function has not been well established in humans. The present study assessed the effect of mephedrone alone and after co-administration with alcohol on neurocognitive function. It was hypothesised that mephedrone would improve psychomotor performance but imp...
8 CitationsSource
#1E. B. de Sousa Fernandes Perna (UM: Maastricht University)H-Index: 4
#2Eef L. Theunissen (UM: Maastricht University)H-Index: 21
Last.Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
view all 5 authors...
Rationale Alcohol and cannabis use have been implicated in aggression. Alcohol consumption is known to facilitate aggression, whereas a causal link between cannabis and aggression has not been clearly demonstrated.
6 CitationsSource
#1K.P.C. KuypersH-Index: 1
#2Eef L. TheunissenH-Index: 21
Last.Johannes G. RamaekersH-Index: 41
view all 8 authors...
#1Eef L. Theunissen (UM: Maastricht University)H-Index: 21
#2Pim R. A. Heckman (UM: Maastricht University)H-Index: 9
Last.Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
view all 9 authors...
Rationale One of the most often reported cognitive deficits of acute cannabis administration is an impaired recall of previously learned information.
11 CitationsSource
#1E. B. de Sousa Fernandes Perna (UM: Maastricht University)H-Index: 4
#2Eef L. Theunissen (UM: Maastricht University)H-Index: 21
Last.Johannes G. Ramaekers (UM: Maastricht University)H-Index: 41
view all 7 authors...
Abstract Previous studies have shown that single doses of MDMA can affect mood and impair memory in humans. The neuropharmacological mechanisms involved in MDMA-induced memory impairment are not clear. Memantine, an NMDA and alpha 7 nicotinic acetylcholine (ACh) receptor antagonist, was able to reverse MDMA-induced memory impairment in rats. This study investigated whether treatment with memantine can prevent MDMA-induced memory impairment in humans. 15 subjects participated in a double-blind, p...
12 CitationsSource
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