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Ruchi Malik
Central University of Rajasthan
42Publications
7H-index
229Citations
Publications 42
Newest
Published on Jan 7, 2019in Structural Chemistry 1.62
Pakhuri Mehta3
Estimated H-index: 3
(Central University of Rajasthan),
Shubham Srivastava5
Estimated H-index: 5
(Central University of Rajasthan)
+ 1 AuthorsRuchi Malik7
Estimated H-index: 7
(Central University of Rajasthan)
Competitive AMPA receptor antagonists serve as the promising and validated strategy towards the development of novel antiepileptic agents. For this purpose, the structure-based virtual screening approach on library of natural compounds led to the discovery of 11 novel diverse competitive AMPA receptor antagonists with better docking and dG bind scores than the co-crystallized ligand. Validation of the screening protocol was accomplished at three levels like superposition, enrichment, and simulat...
Published on Jun 13, 2019in Journal of Biomolecular Structure & Dynamics 3.31
Shubham Srivastava5
Estimated H-index: 5
(Central University of Rajasthan),
Bhanwar Singh Choudhary4
Estimated H-index: 4
(Central University of Rajasthan)
+ 3 AuthorsRuchi Malik7
Estimated H-index: 7
(Central University of Rajasthan)
AbstractConjugated structure based and ligand based drug design techinques have been used previously to unearth putative binding ligands for kinase inhibition. PI3K-δ is a lipid kinase and it has been found abberant in diseases such as cancer,inflammation etc. Preliminarily, protein crystal structure analysis suggest avaibility of two crystal structures with varying degree of root mean square de throughtion in protein back bone and root mean square fluctuation in side chain geometry. Therefore, ...
Published on Apr 1, 2019in Journal of Biomolecular Structure & Dynamics 3.31
Apeksha Shrivastava1
Estimated H-index: 1
,
Shubham Srivastava5
Estimated H-index: 5
(Central University of Rajasthan)
+ 3 AuthorsMymoona Akhter10
Estimated H-index: 10
AbstractProlyl oligopeptidase (POP) enzyme has been studied for various disorders, viz. Schizophrenia, Alzheimer’s, Parkinson’s, Depression, Inflammation, etc., for three decades, but no drug has passed through the clinical trials, possibly because of indigent pharmacokinetics. This might have been a result of similar structures of drug candidates. This study aimed at identifying novel small non-peptidomimetic inhibitors for POP enzyme that could serve as a lead for developing newer drugs. Struc...
Published on Mar 28, 2019in Current Pharmaceutical Design 2.41
Mohini Mishra1
Estimated H-index: 1
(Central University of Rajasthan),
Pramod Kumar9
Estimated H-index: 9
+ 3 AuthorsAmit Modgil12
Estimated H-index: 12
(NDSU: North Dakota State University)
Published on Mar 8, 2019in Structural Chemistry 1.62
Shubham Srivastava5
Estimated H-index: 5
(Central University of Rajasthan),
Ajeesh Vengamthodi (Central University of Rajasthan)+ 3 AuthorsRuchi Malik7
Estimated H-index: 7
(Central University of Rajasthan)
The PI3KCA gene functions by activating cascade signaling pathways leading to cell proliferation, survival, and growth. Being one of the frequently aberrant kinase in various malignancies, isoform selectivity among kinases remains a challenging aspect. In present study, efforts have been made to conceptualize determinants that are responsible for PI3Kα inhibition. Drug design techniques such as 3D-QSAR models, e-pharmacophore models, and shape-based screening utilities were derived from set of m...
Published on Feb 1, 2019in Aaps Pharmscitech 2.61
Pramod Kumar9
Estimated H-index: 9
(Central University of Rajasthan),
Gajanand Sharma15
Estimated H-index: 15
(Panjab University, Chandigarh)
+ 7 AuthorsKaisar Raza18
Estimated H-index: 18
(Central University of Rajasthan)
The present study aimed to orally deliver methylthioadenosine (MTA) to the brain employing solid lipid nanoparticles (SLNs) for the management of neurological conditions like multiple sclerosis. The stearic acid–based SLNs were below 100 nm with almost neutral zeta potential and offered higher drug entrapment and drug loading. Cuprizone-induced demyelination model in mice was employed to mimic the multiple sclerosis–like conditions. It was observed that the MTA-loaded SLNs were able to maintain ...
Published on Nov 2, 2018
Pramod Kumar9
Estimated H-index: 9
,
Ruchi Malik7
Estimated H-index: 7
,
Kaisar Raza18
Estimated H-index: 18
Published on Nov 1, 2018in International Journal of Biological Macromolecules 4.78
Pakhuri Mehta3
Estimated H-index: 3
(Central University of Rajasthan),
Shubham Srivastava5
Estimated H-index: 5
(Central University of Rajasthan)
+ 2 AuthorsRuchi Malik7
Estimated H-index: 7
(Central University of Rajasthan)
Abstract Development of resistance against existing anti-epileptic drugs has alarmed the scientific innovators to find novel potential chemical starting points for the treatment of epilepsy and GABA A inhibition is a promising drug target strategy against epilepsy. The crystal structure of a subtype-selective β3-homopentameric ligand-gated ion channel of GABA A receptor has been used for the first time for screening the Asinex library for discovery of GABA A agonists as potential anti-epileptic ...
Published on May 19, 2018in Journal of Biomolecular Structure & Dynamics 3.31
Poonam Piplani8
Estimated H-index: 8
(Panjab University, Chandigarh),
Manish Sharma4
Estimated H-index: 4
(Maharishi Markandeshwar University, Mullana)
+ 1 AuthorsRuchi Malik7
Estimated H-index: 7
(Central University of Rajasthan)
The present paper describes the synthesis, biological evaluation and molecular simulation studies of a series of N-(4-hydroxyphenyl)-3,4,5-trimethoxybenzamide derivatives with N,N-dialkylaminoethoxy/propoxy moiety as potential memory enhancers with acetylcholinesterase-inhibiting activity having IC50 in low micromolar range (4.0–16.5 μM). All the compounds showed a good degree of agreement between in vivo and in vitro results as most of these derivatives showed dose-dependent increase in percent...
Published on Feb 1, 2018in ACS Chemical Neuroscience 3.86
Pramod Kumar9
Estimated H-index: 9
(Central University of Rajasthan),
Gajanand Sharma15
Estimated H-index: 15
(Panjab University, Chandigarh)
+ 6 AuthorsKaisar Raza18
Estimated H-index: 18
(Central University of Rajasthan)
Multiple sclerosis (MS) is a neurodegenerative disease in which myelin sheath damage occurs due to internal and external factors. MS especially affects the young population. Dimethyl fumarate (DMF) is a promising agent for MS treatment, although it is associated with concerns such as poor brain permeation, multiple dosing, and gastrointestinal flushing. The present study attempts to evaluate the preclinical performance of specially designed DMF-based lipoidal nanoparticles in a cuprizone-induced...
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