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Ruchi Malik
Central University of Rajasthan
34Publications
7H-index
248Citations
Publications 37
Newest
Abstract Docetaxel (DTX), a widely prescribed anticancer agent, is now associated with increased instances of multidrug resistance. Also, being a problematic BCS class IV drug, it poses challenges for the formulators. Henceforth, it was envisioned to synthesize an analogue of DTX with a biocompatible lipid, i.e., palmitic acid. The in-silico studies (molecular docking and simulation) inferred lesser binding of docetaxel palmitate (DTX-PL) with P-gp vis-a-vis DTX and paclitaxel, indicating it to ...
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#1Shweta Sharma (Jamia Hamdard)H-Index: 1
#2Shubham Srivastava (Central University of Rajasthan)H-Index: 5
Last.Mymoona Akhter (Jamia Hamdard)H-Index: 10
view all 10 authors...
AbstractThe Dipeptidyl peptidase-IV (DPP-IV) family of receptors possesses a large binding cavity that imparts promiscuity for number of ligand binding which is not common to other receptors. This ...
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#1Pakhuri Mehta (Central University of Rajasthan)H-Index: 4
#2Ruchi Malik (Central University of Rajasthan)H-Index: 7
AbstractThe seizure controlling activity of human adenosine kinase (AK) has been identified as a promising target for the development of small-molecule inhibitors to be used as potential anti-epile...
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#1Shubham Srivastava (Central University of Rajasthan)H-Index: 5
#2Pakhuri Mehta (Central University of Rajasthan)H-Index: 4
Last.Ruchi Malik (Central University of Rajasthan)H-Index: 7
view all 5 authors...
AbstractChemical entities targeting kinase signalling pathways serve as a potential strategy to combat malignancies. Protein Kinase B or Akt is a validated target for various malignancies and Akt3 ...
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#1Shubham Srivastava (Central University of Rajasthan)H-Index: 5
#2Ajeesh Vengamthodi (Central University of Rajasthan)
Last.Ruchi Malik (Central University of Rajasthan)H-Index: 7
view all 6 authors...
The PI3KCA gene functions by activating cascade signaling pathways leading to cell proliferation, survival, and growth. Being one of the frequently aberrant kinase in various malignancies, isoform selectivity among kinases remains a challenging aspect. In present study, efforts have been made to conceptualize determinants that are responsible for PI3Kα inhibition. Drug design techniques such as 3D-QSAR models, e-pharmacophore models, and shape-based screening utilities were derived from set of m...
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#1Pakhuri Mehta (Central University of Rajasthan)H-Index: 4
#2Shubham Srivastava (Central University of Rajasthan)H-Index: 5
Last.Ruchi Malik (Central University of Rajasthan)H-Index: 7
view all 4 authors...
Competitive AMPA receptor antagonists serve as the promising and validated strategy towards the development of novel antiepileptic agents. For this purpose, the structure-based virtual screening approach on library of natural compounds led to the discovery of 11 novel diverse competitive AMPA receptor antagonists with better docking and dG bind scores than the co-crystallized ligand. Validation of the screening protocol was accomplished at three levels like superposition, enrichment, and simulat...
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#1Shubham Srivastava (Central University of Rajasthan)H-Index: 5
#2Bhanwar Singh Choudhary (Central University of Rajasthan)H-Index: 4
Last.Ruchi Malik (Central University of Rajasthan)H-Index: 7
view all 6 authors...
AbstractConjugated structure based and ligand based drug design techinques have been used previously to unearth putative binding ligands for kinase inhibition. PI3K-δ is a lipid kinase and it has been found abberant in diseases such as cancer,inflammation etc. Preliminarily, protein crystal structure analysis suggest avaibility of two crystal structures with varying degree of root mean square de throughtion in protein back bone and root mean square fluctuation in side chain geometry. Therefore, ...
2 CitationsSource
#2Shubham Srivastava (Central University of Rajasthan)H-Index: 5
Last.Mymoona AkhterH-Index: 10
view all 6 authors...
AbstractProlyl oligopeptidase (POP) enzyme has been studied for various disorders, viz. Schizophrenia, Alzheimer’s, Parkinson’s, Depression, Inflammation, etc., for three decades, but no drug has p...
1 CitationsSource
#1Mohini Mishra (Central University of Rajasthan)H-Index: 1
#2Pramod KumarH-Index: 10
Last.Amit Modgil (NDSU: North Dakota State University)H-Index: 12
view all 6 authors...
1 CitationsSource
#1Pramod Kumar (Central University of Rajasthan)H-Index: 10
#2Gajanand Sharma (Panjab University, Chandigarh)H-Index: 16
Last.Kaisar Raza (Central University of Rajasthan)H-Index: 18
view all 10 authors...
The present study aimed to orally deliver methylthioadenosine (MTA) to the brain employing solid lipid nanoparticles (SLNs) for the management of neurological conditions like multiple sclerosis. The stearic acid–based SLNs were below 100 nm with almost neutral zeta potential and offered higher drug entrapment and drug loading. Cuprizone-induced demyelination model in mice was employed to mimic the multiple sclerosis–like conditions. It was observed that the MTA-loaded SLNs were able to maintain ...
2 CitationsSource
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