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Stuart J. Frank
University of Alabama at Birmingham
Growth hormone receptorEndocrinologyReceptorSignal transductionBiology
154Publications
45H-index
6,727Citations
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Publications 154
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#1Guang Ren (UAB: University of Alabama at Birmingham)
#2Teayoun Kim (UAB: University of Alabama at Birmingham)H-Index: 8
Last. Sushant Bhatnagar (UAB: University of Alabama at Birmingham)H-Index: 6
view all 15 authors...
Targeting rexinoid X receptor (RXR) has been proposed as one of the therapeutic strategies to treat individuals with metabolic syndrome, because RXR heterodimerizes with multiple nuclear receptors that regulate genes involved in metabolism. Despite numerous efforts, RXR ligands (rexinoids) have not been approved for clinical trials to treat metabolic syndrome due to the serious side effects such as hypertriglyceridemia and altered thyroid hormone axis. Herein, we demonstrate a novel rexinoid-lik...
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#1Sirisha Thambuluru (UAB: University of Alabama at Birmingham)
#2Imran Unal (UAB: University of Alabama at Birmingham)
Last. Ronadip R. Banerjee (UAB: University of Alabama at Birmingham)H-Index: 10
view all 6 authors...
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#1Sobuj Mia (UAB: University of Alabama at Birmingham)H-Index: 1
#2Mariame S. Kane (UAB: University of Alabama at Birmingham)H-Index: 1
Last. Jianhua Zhang (UAB: University of Alabama at Birmingham)H-Index: 68
view all 12 authors...
Cell autonomous circadian clocks have emerged as temporal orchestrators of numerous biological processes. For example, the cardiomyocyte circadian clock modulates transcription, translation, posttranslational modifications, ion homeostasis, signaling cascades, metabolism, and contractility of the heart over the course of the day. Circadian clocks are composed of more than 10 interconnected transcriptional modulators, all of which have the potential to influence the cardiac transcriptome (and ult...
1 CitationsSource
#1Daniel DiToro (UAB: University of Alabama at Birmingham)H-Index: 5
#2Stacey N. Harbour (UAB: University of Alabama at Birmingham)H-Index: 4
Last. Henrietta Turner (UAB: University of Alabama at Birmingham)H-Index: 9
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Appropriate balance of T helper 17 (Th17) and regulatory T (Treg) cells maintains immune tolerance and host defense. Disruption of Th17-Treg cell balance is implicated in a number of immune-mediated diseases, many of which display dysregulation of the insulin-like growth factor (IGF) system. Here, we show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system. Signaling through IGF receptor (IGF1R) activated the protein kinase B-mamma...
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#1Ashiya Buckels (UAB: University of Alabama at Birmingham)H-Index: 2
#2Yue Zhang (UAB: University of Alabama at Birmingham)H-Index: 15
Last. Stuart J. Frank (UAB: University of Alabama at Birmingham)H-Index: 45
view all 7 authors...
Abstract Melanoma is the most aggressive skin cancer. Its aggressiveness is most commonly attributed to ERK pathway mutations leading to constitutive signaling. Though initial tumor regression results from targeting this pathway, resistance often emerges. Interestingly, interrogation of the NCI-60 database indicates high growth hormone receptor (GHR) expression in melanoma cell lines. To further characterize melanoma, we tested responsiveness to human growth hormone (GH). GH treatment resulted i...
1 CitationsSource
#1Yue Zhang (UAB: University of Alabama at Birmingham)H-Index: 15
#2Sajina Gc (UAB: University of Alabama at Birmingham)H-Index: 1
Last. Stuart J. Frank (UAB: University of Alabama at Birmingham)H-Index: 45
view all 8 authors...
Abstract Human growth hormone (GH) binds and activates GH receptor (GHR) and prolactin (PRL) receptor (PRLR). LNCaP human prostate cancer cells express only GHR. A soluble fragment of IGF-1 receptor (IGF-1R) extracellular domain (sol IGF-1R) interacts with GHR and blocks GH signaling. We now explore sol IGF-1R's specificity for inhibiting GH signaling via GHR vs. PRLR and test GHR and PRLR extracellular domain inhibition determinants. Although T47D human breast cancer cells express GHR and PRLR,...
1 CitationsSource
OBJECTIVES: Despite training in academic medical centers, many residents and fellows lack an understanding of the different career paths in academic medicine. Without this fundamental knowledge, choosing an academic career pathway and transitioning to junior faculty is challenging. We started the Pathways in Academic Medicine course ("Pathways") to introduce residents and fellows to the wide array of academic career pathways and to expose them to the concepts and resources needed to transition s...
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#1Ryan Berry (UAB: University of Alabama at Birmingham)H-Index: 14
#2Graham R. McGinnis (UAB: University of Alabama at Birmingham)H-Index: 4
Last. Stuart J. Frank (UAB: University of Alabama at Birmingham)H-Index: 45
view all 5 authors...
: Growth hormone (GH) has been shown to act directly on multiple tissues throughout the body. Historically, it was believed that GH acted directly in the liver and only indirectly in other tissues via insulin-like growth hormone 1 (IGF-1). Despite extensive work to describe GH action in individual tissues, a comparative analysis of acute GH signaling in key metabolic tissues has not been performed. Herein, we address this knowledge gap. Acute tissue response to human recombinant GH was assessed ...
1 CitationsSource
#1Rachel A. Brewer (UAB: University of Alabama at Birmingham)H-Index: 7
#2Helen E. Collins (UAB: University of Alabama at Birmingham)H-Index: 8
Last. Martin E. Young (UAB: University of Alabama at Birmingham)H-Index: 1
view all 15 authors...
Abstract Recent studies suggest that the time of day at which food is consumed dramatically influences clinically-relevant cardiometabolic parameters (e.g., adiposity, insulin sensitivity, and cardiac function). Meal feeding benefits may be the result of daily periods of feeding and/or fasting, highlighting the need for improved understanding of the temporal adaptation of cardiometabolic tissues (e.g., heart) to fasting. Such studies may provide mechanistic insight regarding how time-of-day-depe...
5 CitationsSource
#1Yimin Fang (SIU: Southern Illinois University Carbondale)H-Index: 16
#2Cristal M. Hill (SIU: Southern Illinois University Carbondale)H-Index: 10
Last. Andrzej Bartke (SIU: Southern Illinois University Carbondale)H-Index: 43
view all 17 authors...
It is well documented that inhibition of mTORC1 (defined by Raptor), a complex of mechanistic target of rapamycin (mTOR), extends life span, but less is known about the mechanisms by which mTORC2 (defined by Rictor) impacts longevity. Here, rapamycin (an inhibitor of mTOR) was used in GHR-KO (growth hormone receptor knockout) mice, which have suppressed mTORC1 and up-regulated mTORC2 signaling, to determine the effect of concurrently decreased mTORC1 and mTORC2 signaling on life span. We found t...
13 CitationsSource
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