Noriyoshi Ogawa
Hamamatsu University
ImmunologyRheumatoid arthritisDiabetes mellitusMedicineBiology
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Publications 50
#1Takahiko Sugihara (Tokyo Medical and Dental University)H-Index: 13
#2Hitoshi Hasegawa (Ehime University)H-Index: 33
Last. Noriyoshi Ogawa (Hamamatsu University)H-Index: 21
view all 21 authors...
BACKGROUND: Relapses frequently occur in giant cell arteritis (GCA), and long-term glucocorticoid therapy is required. The identification of associated factors with poor treatment outcomes is important to decide the treatment algorithm of GCA. METHODS: We enrolled 139 newly diagnosed GCA patients treated with glucocorticoids between 2007 and 2014 in a retrospective, multi-center registry. Patients were diagnosed with temporal artery biopsy, 1990 American College of Rheumatology classification cr...
#1Yasuoki HoriikeH-Index: 2
#2Yuzo SuzukiH-Index: 13
Last. Takafumi SudaH-Index: 2
view all 12 authors...
OBJECTIVES: Macrophage-mannose receptor, CD206, is a marker of alternatively activated macrophages. Activated macrophages play key roles in DM. Interstitial lung disease (ILD) is a leading cause of mortality in patients with DM/clinically amyopathic DM (CADM). In particular, patients with the anti-melanoma differential gene 5 antibody (MDA5) frequently develop fatal rapid progressive ILD. This study aimed to evaluate the clinical implications of alternatively activated macrophages in patients wi...
2 CitationsSource
#1Reina Taguchi (Hamamatsu University)H-Index: 1
#2Takafumi Naito (Hamamatsu University)H-Index: 16
Last. Junichi Kawakami (Hamamatsu University)H-Index: 13
view all 6 authors...
Abstract Objective This study aimed to evaluate the relationship between endogenous CYP3A markers and plasma amlodipine (AML) exposure and metabolism parameters in early postpartum and non-peripartum women. Methods Twenty-four AML-treated early postpartum women with hypertensive disorders of pregnancy and 30 non-peripartum women with essential hypertension were enrolled. Blood samples for determination of CYP3A markers including total cholesterol-adjusted 4β-hydroxycholesterol (4β-OHC/TC), 25-hy...
#1Takafumi Naito (Hamamatsu University)H-Index: 16
#2Junya Ohshiro (Hamamatsu University)H-Index: 1
Last. Junichi Kawakami (Hamamatsu University)H-Index: 13
view all 7 authors...
Abstract Background This study aimed to evaluate the relationships between concomitant biologic disease-modifying anti-rheumatic drugs (DMARDs) and prednisolone administration and blood tacrolimus exposure or serum CYP3A4/5-related markers in rheumatoid arthritis (RA) patients without severe disease activity. Methods Forty-six RA patients treated with oral tacrolimus once daily for maintenance of clinical remission to moderate disease activity were enrolled. The blood concentrations of tacrolimu...
#1Noriyoshi Ogawa (Hamamatsu University)H-Index: 21
#2Hiroyuki OhashiH-Index: 8
Last. Yuichiro Maekawa (Hamamatsu University)H-Index: 3
view all 15 authors...
AbstractThe aim of this study was to assess abatacept in rheumatoid arthritis (RA) patient. Patients (20 men, 89 women, aged 61.9 ± 10.4 y) who responded inadequately to conventional synthetic dise...
#1Yasunori Enomoto (Hamamatsu University)H-Index: 12
#2Yuzo Suzuki (Hamamatsu University)H-Index: 13
Last. Takafumi Suda (Hamamatsu University)H-Index: 40
view all 17 authors...
Background Macrophage activation is involved in the pathogenesis of polymyositis (PM)/dermatomyositis (DM). CD163, a scavenger receptor expressed on the surface of activated macrophages, mediates anti-inflammatory functions. This study aimed to evaluate the clinical significance of soluble CD163 (sCD163) in PM/DM-related interstitial lung disease (ILD).
13 CitationsSource
#1Yasuaki Mino (Hamamatsu University)H-Index: 11
#2Takafumi Naito (Hamamatsu University)H-Index: 16
Last. Junichi Kawakami (Hamamatsu University)H-Index: 13
view all 5 authors...
BackgroundMycophenolate mofetil has recently been reported to be effective against systemic lupus erythematosus. The influence of the pharmacokinetics of mycophenolic acid, the active form of mycophenolate mofetil and the major inactive mycophenolic acid phenolic glucuronide on the activity of the target enzyme inosine 5′-monophosphate dehydrogenase, is expected to be revealed. The aim of this study was to identify the factors associated with inosine 5′-monophosphate dehydrogenase activity in sy...
#1Takafumi Naito (Hamamatsu University)H-Index: 16
#2Yasuaki Mino (Hamamatsu University)H-Index: 11
Last. Junichi Kawakami (Hamamatsu University)H-Index: 13
view all 5 authors...
#1Fumihiko Miyoshi (Saitama Medical University)H-Index: 7
#2Kyoko Honne (Jichi Medical University)H-Index: 4
Last. Toshihide Mimura (Saitama Medical University)H-Index: 19
view all 6 authors...
AbstractObjectives: The aim of the present study was to generate a novel method for predicting the clinical response to infliximab (IFX), using a machine-learning algorithm with only clinical data obtained before the treatment in rheumatoid arthritis (RA) patients.Methods: We obtained 32 variables out of the clinical data on the patients from two independent hospitals. Next, we selected both clinical parameters and machine-learning algorithms and decided the candidates of prediction method. Thes...
6 CitationsSource
#1Makoto Sano (Hamamatsu University)H-Index: 6
#2Hiroshi Satoh (Hamamatsu University)H-Index: 34
Last. Hideharu Hayashi (Hamamatsu University)H-Index: 32
view all 14 authors...
Cardiac involvement in systemic sclerosis (SSc) is considerably frequent in autopsy, but the early identification is clinically difficult. Recent advantages in cardiac magnetic resonance (CMR) enabled to detect myocardial fibrotic scar as late gadolinium enhancement (LGE). We aimed to examine the prevalence and distribution of LGE in patients with SSc, and associate them with clinical features, electrocardiographic abnormalities and cardiac function. Forty patients with SSc (58 ± 14 years-old, 3...
8 CitationsSource