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Stella Victorelli
Newcastle University
DNA damageTelomereAgeingSenescenceBiology
10Publications
4H-index
79Citations
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Publications 13
Newest
#1Anthony LagnadoH-Index: 3
#2Stella VictorelliH-Index: 4
Last. João F. PassosH-Index: 29
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#1Stella Victorelli (Mayo Clinic)H-Index: 4
#2João F. Passos (Mayo Clinic)H-Index: 29
ABSTRACTCellular senescence is an irreversible cell cycle arrest, which can be triggered by a number of stressors, including telomere damage. Among many other phenotypic changes, senescence is acco...
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#1LaTonya J. Hickson (Mayo Clinic)H-Index: 16
#2Larissa Prata (Mayo Clinic)H-Index: 3
Last. Kyra L. Jordan (Mayo Clinic)H-Index: 15
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2 CitationsSource
#1Stella Victorelli (Newcastle University)H-Index: 4
#2Anthony Lagnado (Newcastle University)H-Index: 3
Last. João F. Passos (Newcastle University)H-Index: 29
view all 18 authors...
Cellular senescence has been shown to contribute to skin ageing. However, the role of melanocytes in the process is understudied. Our data show that melanocytes are the only epidermal cell type to express the senescence marker p16(INK4A) during human skin ageing. Aged melanocytes also display additional markers of senescence such as reduced HMGB1 and dysfunctional telomeres, without detectable telomere shortening. Additionally, senescent melanocyte SASP induces telomere dysfunction in paracrine ...
2 CitationsSource
#1LaTonya J. Hickson (Mayo Clinic)H-Index: 16
#2Larissa Prata (Mayo Clinic)H-Index: 3
Last. James L. KirklandH-Index: 55
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Abstract Background Senescent cells, which can release factors that cause inflammation and dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with ageing and at etiological sites in multiple chronic diseases. Senolytics, including the combination of Dasatinib and Quercetin (D + Q), selectively eliminate senescent cells by transiently disabling pro-survival networks that defend them against their own apoptotic environment. In the first clinical trial of senolytics, D + ...
20 CitationsSource
#1Anna Walaszczyk (Newcastle University)H-Index: 2
#2Emily Dookun (Newcastle University)H-Index: 3
Last. Gavin D. Richardson (Newcastle University)H-Index: 12
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4 CitationsSource
#1Mikolaj Ogrodnik (Newcastle University)H-Index: 12
#2Yi Zhu (Mayo Clinic)H-Index: 14
Last. Diana Jurk (Newcastle University)H-Index: 21
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Summary Cellular senescence entails a stable cell-cycle arrest and a pro-inflammatory secretory phenotype, which contributes to aging and age-related diseases. Obesity is associated with increased senescent cell burden and neuropsychiatric disorders, including anxiety and depression. To investigate the role of senescence in obesity-related neuropsychiatric dysfunction, we used the INK-ATTAC mouse model, from which p16 Ink4a -expressing senescent cells can be eliminated, and senolytic drugs dasat...
16 CitationsSource
#1Rhys Anderson (Newcastle University)H-Index: 7
#2Anthony Lagnado (Newcastle University)H-Index: 3
Last. João F. Passos (Newcastle University)H-Index: 29
view all 34 authors...
Abstract Ageing is the biggest risk factor for cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening, has been implicated in age‐related tissue dysfunction. Here, we address the question of how senescence is induced in rarely dividing/post‐mitotic cardiomyocytes and investigate whether clearance of senescent cells attenuates age‐related cardiac dysfunction. During ageing, human and murine cardiomyocytes acquire a senescent‐like phenotype characterised by pe...
16 CitationsSource
#1Stella Victorelli (Newcastle University)H-Index: 4
#2João F. Passos (Newcastle University)H-Index: 29
1 CitationsSource
#1Rhys Anderson (Newcastle University)H-Index: 7
#2Anthony Lagnado (Newcastle University)H-Index: 3
Last. João F. Passos (Newcastle University)H-Index: 29
view all 34 authors...
Ageing is the biggest risk factor for cardiovascular health and is associated with increased incidence of cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening, has been implicated in age-related tissue dysfunction. Here, we address the question of how senescence is induced in rarely dividing/post-mitotic cardiomyocytes and investigate if clearance of senescent cells attenuates age related cardiac dysfunction. During ageing, human and murine cardiomyocytes ...
Source
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