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Lisa R. Yanek
Johns Hopkins University
249Publications
44H-index
7,640Citations
Publications 249
Newest
#1Sven J. van der Lee (EUR: Erasmus University Rotterdam)H-Index: 24
#2Maria J. Knol (EUR: Erasmus University Rotterdam)H-Index: 3
Last.Charles D. Smith (UC Davis: University of California, Davis)H-Index: 122
view all 62 authors...
Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial volume. Two loci, associated with occipital (6q22.32) and temporal lobe volume (12q14.3), were previously reported to associate with intracranial and hippocamp...
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#1Tuomas O. Kilpelaeinen (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 33
#2Amy R. Bentley (NIH: National Institutes of Health)H-Index: 16
Last.Ruth Loos (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 111
view all 237 authors...
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We f...
6 CitationsSource
#2Deepti JainH-Index: 14
Last.Peter M. VisscherH-Index: 109
view all 41 authors...
1 CitationsSource
#1Margaret A. Taub (Johns Hopkins University)H-Index: 18
#2Joshua S. Weinstock (UM: University of Michigan)H-Index: 1
Last.Rasika A. Mathias (Johns Hopkins University)H-Index: 44
view all 125 authors...
Telomeres shorten in replicating somatic cells and with age; in human leukocytes, telomere length (TL) is associated with a host of aging-related diseases. To date, 16 genome-wide association studies (GWAS) have identified twenty-three loci associated with leukocyte TL, but prior studies were primarily in individuals of European and Asian ancestry and relied on laboratory assays including Southern Blot and qPCR to quantify TL. Here, we estimated TL bioinformatically, leveraging whole genome sequ...
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#1Virginia S. Hahn (Johns Hopkins University)H-Index: 4
#2Wendy Ying (Johns Hopkins University)H-Index: 2
Last.Kavita Sharma (Johns Hopkins University)H-Index: 9
view all 14 authors...
Introduction Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease with no proven pharmacologic therapies. Cardiac amyloidosis shares common features of HFpEF, however endomyocardial biopsy data are only available on limited subsets of HFpEF patients. To our knowledge, this is the first study to comprehensively characterize biopsy data for patients referred for HFpEF evaluation. Methods We included patients referred to the Johns Hopkins HFpEF Clinic who underwent righ...
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#1Yun J. Sung (WashU: Washington University in St. Louis)H-Index: 7
#2L de Las Fuentes (WashU: Washington University in St. Louis)H-Index: 2
Last.Alanna C. Morrison (University of Texas Health Science Center at Houston)H-Index: 44
view all 279 authors...
U.S. National Heart, Lung, and Blood Institute (NHLBI) (K25HL121091 to Y.J.S.); National Institutes of Health (R01HL118305).
Source
#1Eunice Yang (Johns Hopkins University)H-Index: 10
#2Joban Vaishnav (Johns Hopkins University)
Last.Kavita Sharma (Johns Hopkins University)H-Index: 9
view all 8 authors...
Introduction Heart failure with preserved ejection fraction (HFpEF) constitutes half of all HF hospitalizations. Atrial fibrillation (AF) is a common co-morbid condition in HFpEF and an independent predictor of mortality in patients with HFpEF. The effect of AF on hospitalized HFpEF, however, has not been well described. Here, we report the effect of AF on response to acute HF treatment and 30-day hospital readmissions in a hospitalized HFpEF cohort. Methods Subjects enrolled in the Randomized E...
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#1Joban Vaishnav (Johns Hopkins University)
#2Lisa R. Yanek (Johns Hopkins University)H-Index: 44
Last.Kavita Sharma (Johns Hopkins University)H-Index: 9
view all 7 authors...
Introduction Heart failure with preserved ejection fraction (HFpEF) constitutes half of HF hospitalizations in the U.S. Right ventricular dysfunction (RVD) is associated with high morbidity and mortality in HFpEF and serves as an important therapeutic target. The use of low-dose dopamine (DA) has not shown benefit in the treatment of decompensated HF patients; however, the effect of DA on HFpEF patients with RVD (HFpEF-RVD) is unknown. Methods We analyzed subjects enrolled in the Randomized Eval...
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#1Brian G Kral (Johns Hopkins University)H-Index: 17
#2Diane M. Becker (Johns Hopkins University)H-Index: 51
Last.Rita R. Kalyani (Johns Hopkins University)H-Index: 26
view all 7 authors...
Abstract Aim Type 2 diabetes (T2DM) in a first-degree relative is a risk factor for incident diabetes. Americans of African ancestry (AA) have higher rates of T2DM than Americans of European ancestry (EA). Thus, we aimed to determine whether the presence, number and kinship of affected relatives are associated with race-specific T2DM incidence in a prospective study of participants from the Genetic Study of Atherosclerosis Risk (GeneSTAR), who underwent baseline screening including a detailed fa...
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#1P S de Vries (University of Texas Health Science Center at Houston)H-Index: 3
#2Michael R. Brown (University of Texas Health Science Center at Houston)H-Index: 6
Last.Alanna C. Morrison (University of Texas Health Science Center at Houston)H-Index: 44
view all 264 authors...
A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394...
6 CitationsSource
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