Lisa R. Yanek
Johns Hopkins University
Genome-wide association studyCardiologyGeneticsDiabetes mellitusMedicine
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Publications 268
#1Virginia S. Hahn (Johns Hopkins University)H-Index: 5
#2Lisa R. Yanek (Johns Hopkins University)H-Index: 46
Last. C. Danielle Hopkins (Johns Hopkins University)H-Index: 1
view all 21 authors...
Abstract Objectives This study prospectively evaluated endomyocardial biopsies in patients with heart failure with preserved ejection fraction (HFpEF) to identify histopathologic phenotypes and their association with clinical characteristics. Background Myocardial tissue analysis from a prospectively defined HFpEF cohort reflecting contemporary comorbidities is lacking. Methods Patients with HFpEF (EF ≥50%) referred to the Johns Hopkins HFpEF Clinic between August 2014 and September 2018 were en...
#1Adrienne M. Stilp (UW: University of Washington)H-Index: 23
#2Leslie S. Emery (UW: University of Washington)H-Index: 7
view all 72 authors...
Genotype-phenotype association studies often combine phenotype data from multiple studies to increase power. Harmonization of the data usually requires substantial effort due to heterogeneity in phenotype definitions, study design, data collection procedures, and data set organization. Here we describe a centralized system for phenotype harmonization that includes input from phenotype domain and study experts, quality control, documentation, reproducible results, and data sharing mechanisms. Thi...
#1Nicola J. Armstrong (Murdoch University)H-Index: 33
#2Karen A. Mather (UNSW: University of New South Wales)H-Index: 33
Last. Nicole Dueker (UM: University of Miami)H-Index: 13
view all 86 authors...
Background and Purpose: Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause. In the first st...
#2Dhananjay VaidyaH-Index: 47
Last. Nisa M. MaruthurH-Index: 27
view all 11 authors...
#1Kanika Kanchan (Johns Hopkins University)H-Index: 1
#2Kruthika R. Iyer (Johns Hopkins University)H-Index: 1
Last. Linzhao Cheng (Johns Hopkins University)H-Index: 51
view all 25 authors...
Abstract Human induced pluripotent stem cell (hiPSC) lines have previously been generated through the NHLBI sponsored NextGen program at nine individual study sites. Here, we examined the structural integrity of 506 hiPSC lines as determined by copy number variations (CNVs). We observed that 149 hiPSC lines acquired 258 CNVs relative to donor DNA. We identified six recurrent regions of CNVs on chromosomes 1, 2, 3, 16 and 20 that overlapped with cancer associated genes. Furthermore, the genes map...
#1L. de las Fuentes (WashU: Washington University in St. Louis)H-Index: 1
#1Lisa de las Fuentes (WashU: Washington University in St. Louis)H-Index: 25
Last. Alisa K. Manning (Harvard University)H-Index: 40
view all 222 authors...
Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, “Some College” (yes/no) and “Graduated College” (yes/no). Interactions were evaluated using both a 1 degree of freedom (DF) interaction term and a 2DF joint test of genetic and interaction effects....
1 CitationsSource
#1Joban Vaishnav (Johns Hopkins University)H-Index: 3
#1Joban Vaishnav (Johns Hopkins University)
Last. Kavita Sharma (Johns Hopkins University)H-Index: 12
view all 8 authors...
Purpose Right ventricular dysfunction (RVD) is associated with poor outcomes in heart failure with preserved ejection fraction (HFpEF) and serves as an important therapeutic target. Though treatment with low-dose dopamine (DA) has not shown benefit decompensated HF, we sought to evaluate the effect of DA on HFpEF patients with RVD (HFpEF-RVD), which is currently is unknown. Methods We analyzed subjects enrolled in the Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patien...
#1Julie Hahn (University of Texas Health Science Center at Houston)
#2Yi-Ping Fu (NIH: National Institutes of Health)H-Index: 3
Last. Albert V. Smith (University of Iceland)H-Index: 109
view all 45 authors...
Background Genome-wide association studies have identified multiple genomic loci associated with coronary artery disease, but most are common variants in non-coding regions that provide limited information on causal genes and etiology of the disease. To better understand etiological pathways that might lead to discovery of new treatments or prevention strategies, we focused our investigation on low-frequency and rare sequence variations primarily residing in coding regions of the genome while al...
#1Erin P. O’Donnell (JHUSOM: Johns Hopkins University School of Medicine)
#2Lisa Yanek (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 4
Last. Thuy L. Ngo (JHUSOM: Johns Hopkins University School of Medicine)
view all 5 authors...
#1Yousef HannawiH-Index: 6
#2Lisa R. YanekH-Index: 46
Last. Paul A. NyquistH-Index: 22
view all 8 authors...
Introduction: We previously reported impaired manipulative manual dexterity measured by grooved peg-board test (GPBT) in healthypeople with increased total brain ischemic white matter hyperintensit...