Maurice P.H.M. Jansen
Erasmus University Rotterdam
Publications 44
#1Manouk K. Bos (EUR: Erasmus University Rotterdam)
#2Lindsay Angus (EUR: Erasmus University Rotterdam)H-Index: 1
Last.Stefan Sleijfer (EUR: Erasmus University Rotterdam)H-Index: 69
view all 7 authors...
Abstract Molecular profiling of tumor derived cell free DNA (cfDNA) is gaining ground as a prognostic and predictive biomarker. However to what extent cfDNA reflects the full metastatic landscape as currently determined by tumor tissue analysis remains controversial. Though technically challenging, whole exome sequencing (WES) of cfDNA enables thorough evaluation of somatic alterations. Here, we review the feasibility of WES of cfDNA and determine the sensitivity of WES-detected single nucleotid...
#1D.T. Kruger (VU: VU University Amsterdam)H-Index: 1
#2Maurice P.H.M. Jansen (EUR: Erasmus University Rotterdam)H-Index: 12
Last.Epie Boven (VU: VU University Amsterdam)H-Index: 48
view all 9 authors...
#2Christina StanglH-Index: 1
Last.Wigard P. KloostermanH-Index: 33
view all 13 authors...
Somatic genomic structural variations (SVs) are promising personalized biomarkers for sensitive and specific detection of circulating tumor DNA (ctDNA) in liquid biopsies. However, affordable and fast identification of such SV biomarkers is challenging, which hinders routine use in the clinic. Here, we developed a novel approach - termed SHARC - for rapid discovery of somatic SVs as personalized tumor biomarkers. SHARC combines low coverage cancer genome sketching by using Oxford Nanopore sequen...
#1B. EyckH-Index: 1
#2Bo Jan NoordmanH-Index: 7
Last.W.N.M. DinjensH-Index: 10
view all 10 authors...
#1Lisanne F. van Dessel (EUR: Erasmus University Rotterdam)H-Index: 2
#2Silvia R. Vitale (University of Catania)H-Index: 1
Last.Martijn P. Lolkema (EUR: Erasmus University Rotterdam)H-Index: 13
view all 10 authors...
textabstractThe emerging interest in circulating tumor DNA (ctDNA) analyses for clinical trials has necessitated the development of a high-throughput method for fast, reproducible, and efficient isolation of ctDNA. Currently, the majority of ctDNA studies use the manual QIAamp (QA) platform to isolate DNA from blood. The purpose of this study was to compare two competing automated DNA isolation platforms [Maxwell (MX) and QIAsymphony (QS)] to the current ‘gold standard’ QA to facilitate high-thr...
2 CitationsSource
#1Silvia R. Vitale (University of Catania)H-Index: 1
#2Anieta M. Sieuwerts (EUR: Erasmus University Rotterdam)H-Index: 42
Last.John W. M. Martens (EUR: Erasmus University Rotterdam)H-Index: 54
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The detection of mutated genes in cell-free DNA (cfDNA) in plasma has emerged as an important minimally invasive way to obtain detailed information regarding tumor biology. Reliable determination of circulating tumor–derived DNA, often present at a low quantity amidst an excess of normal DNA in plasma, would be of added value for screening and monitoring of cancer patients and for hypothesis-generating studies in valuable retrospective cohorts. Our aim was to establish a workflow to simultaneous...
#1Maurice P.H.M. Jansen (EUR: Erasmus University Rotterdam)H-Index: 12
#2Rob van Tulder (EUR: Erasmus University Rotterdam)H-Index: 19
Last.Rikky AfriantoH-Index: 1
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Governments around the world are adopting inclusive growth agendas. The ambition to align economic growth ambitions with broader-based social benefits is increasingly embraced by corporations to limit the ‘negative externalities’ and enhance the ‘positive externalities’ of their operations. Therefore, micro-level corporate strategies and macro-level national ambitions meet at the meso-level of networks and clusters. This requires societal spheres to collaborate and search for alternative governa...
2 CitationsSource
#1Lindsay Angus (EUR: Erasmus University Rotterdam)H-Index: 1
#2E. J. van Helden (VUmc: VU University Medical Center)H-Index: 1
Last.Maurice P.H.M. Jansen (EUR: Erasmus University Rotterdam)H-Index: 12
view all 11 authors...
#1B. Eyck (EUR: Erasmus University Rotterdam)H-Index: 1
#2Bo Jan Noordman (EUR: Erasmus University Rotterdam)H-Index: 7
Last.Winand N. M. Dinjens (EUR: Erasmus University Rotterdam)H-Index: 46
view all 10 authors...
#1Yinghui Zhang (LEI: Leiden University)H-Index: 4
#2Lynn Wester (LEI: Leiden University)H-Index: 2
Last.Bob van de Water (LEI: Leiden University)H-Index: 33
view all 18 authors...
Antiestrogen resistance in estrogen receptor positive (ER+) breast cancer is associated with increased expression and activity of insulin-like growth factor 1 receptor (IGF1R). Here, a kinome siRNA screen has identified 10 regulators of IGF1R-mediated antiestrogen with clinical significance. These include the tamoxifen resistance suppressors BMPR1B, CDK10, CDK5, EIF2AK1, and MAP2K5, and the tamoxifen resistance inducers CHEK1, PAK2, RPS6KC1, TTK, and TXK. The p21-activated kinase 2, PAK2, is the...
4 CitationsSource