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Haijun Liu
Southern Medical University
EndocrinologyType 2 Diabetes MellitusGut floraDiabetes mellitusMedicine
7Publications
4H-index
101Citations
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Publications 7
Newest
#1Chen Wang (SJTU: Shanghai Jiao Tong University)H-Index: 13
#2Hong Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Cheng Hu (SJTU: Shanghai Jiao Tong University)H-Index: 29
view all 7 authors...
Abstract Background Alterations in gut microbiota have been associated with improvements in blood glucose due to bariatric surgery. Objectives Our aim is to identify specific gut microbiota that contribute to the remission of T2D after RYGB and SG. Methods Rats fed a high-fat diet (HFD) were administered a low dose of streptozotocin as T2D models; next, their caecum content was collected 8 weeks after RYGB and SG. We also used case-control of gut microbial profiles of T2D patients and healthy pe...
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#1Haijun Liu (Southern Medical University)H-Index: 4
#2Hong Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 4
Last. Xueli Zhang (Southern Medical University)H-Index: 4
view all 6 authors...
Abstract Background The foregut theory posits that proximal small intestine plays an important role in the improvement of type 2 diabetes (T2D) after Roux-en-Y gastric bypass (RYGB). Objective To study the possible role of proximal jejunum in the treatment of T2D after RYGB via the analysis of DNA methylation and transcriptome. Setting Laboratories of Diabetes Institute. Methods Two batches of T2D rats undergoing surgeries (RYGB, and sham operation as control) were established independently. The...
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#1Cheng HuH-Index: 29
#2Weiping JiaH-Index: 58
Last. Haijun LiuH-Index: 4
view all 3 authors...
Background: Changes in gut microbiota induced by bariatric surgery have been associated with metabolic benefits. Objectives: Our aim was to identify specific gut microbiota that may contribute to the improvement of type 2 diabetes (T2D) after RYGB.Setting: Laboratories of Shanghai Diabetes Institute and Shanghai Sixth People’s Hospital. Methods: Diabetic rats induced via a high-fat diet and low-dose streptozotocin administration were randomized to RYGB or sham surgery (SHAM), and stool samples w...
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#1Haijun Liu (Southern Medical University)H-Index: 4
#2Hong Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Xueli Zhang (Southern Medical University)H-Index: 4
view all 6 authors...
Abstract Background Changes in gut microbiota induced by bariatric surgery have been associated with metabolic benefits. Objectives Our aim was to identify specific gut microbiota that may contribute to the improvement of type 2 diabetes (T2D) after Roux-en-Y gastric bypass (RYGB). Setting Laboratories of Shanghai Diabetes Institute and Shanghai Sixth People's Hospital. Methods Diabetic rats induced via a high-fat diet and low-dose streptozotocin administration were randomized to RYGB or sham su...
11 CitationsSource
#1Haijun Liu (Southern Medical University)H-Index: 4
#2Cheng Hu (Southern Medical University)H-Index: 29
Last. Weiping Jia (SJTU: Shanghai Jiao Tong University)H-Index: 58
view all 4 authors...
Type 2 diabetes mellitus is becoming increasingly prevalent worldwide and has become one of the greatest threats to global health. Bariatric surgery was initially designed to achieve weight loss and subsequently was noted to induce improvements or remission of type 2 diabetes. Currently, these bariatric operations such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are the most effective procedures for the treatment of obesity and type 2 diabetes mellitus worldwide. However, the ...
38 CitationsSource
#1Yong Yan (SJTU: Shanghai Jiao Tong University)H-Index: 1
#1Yong YanH-Index: 1
Last. Xueli ZhangH-Index: 4
view all 10 authors...
The aim of the study is to compare Roux-en-Y gastric bypass (RYGB) surgery versus medical treatment for type 2 diabetes mellitus (T2DM) in obese patients. Bariatric surgery can achieve remission of T2DM in obese patients. RYGB surgery has been performed as one of the most common surgical treatment options for obese patients with T2DM, but the efficacy of RYGB surgery comparing with medical treatment alone has not been conclusively determined. A systematic literature search identified randomized ...
34 CitationsSource
#1Yong Yan (Southern Medical University)H-Index: 1
#2Zhou Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Xueli Zhang (Southern Medical University)H-Index: 4
view all 12 authors...
Background Roux-en-Y gastric bypass (RYGB) is an effective surgical treatment for type 2 diabetes mellitus (T2DM). The present study aimed to investigate the effects of RYGB on glucose homeostasis, lipid metabolism, and intestinal morphological adaption, as well as hepatic and intestinal gluconeogenesis.
18 CitationsSource
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