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James R. Sowers
University of Missouri
834Publications
83H-index
34.9kCitations
Publications 834
Newest
Published on Jul 1, 2019in Biochimica et Biophysica Acta 3.44
Guanghong Jia18
Estimated H-index: 18
(University of Missouri),
Annayya R. Aroor29
Estimated H-index: 29
(University of Missouri)
+ 1 AuthorsJames R. Sowers83
Estimated H-index: 83
Abstract Increased cardiovascular disease in aging is partly a consequence of the vascular endothelial cell (EC) senescence and associated vascular dysfunction. In this contest, EC senescence is a pathophysiological process of structural and functional changes including dysregulation of vascular tone, increased endothelium permeability, arterial stiffness, impairment of angiogenesis and vascular repair, and a reduction of EC mitochondrial biogenesis. Dysregulation of cell cycle, oxidative stress...
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Published on Apr 15, 2019
Guanghong Jia18
Estimated H-index: 18
(University of Missouri),
Javad Habibi36
Estimated H-index: 36
(University of Missouri)
+ 6 AuthorsJames R. Sowers83
Estimated H-index: 83
(University of Missouri)
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Published on Apr 1, 2019in Hypertension 6.82
Annayya R. Aroor29
Estimated H-index: 29
,
Javad Habibi36
Estimated H-index: 36
+ 6 AuthorsAdam Whaley-Connell44
Estimated H-index: 44
Obesity is characterized by enhanced MR (mineralocorticoid receptor) activation, vascular stiffness, and associated cardiovascular and kidney disease. Consumption of a Western-style diet (WD), high in saturated fat and refined carbohydrates, by female mice, leads to obesity and vascular stiffening. Use of ECMR (endothelial cell–specific MR) knockout mice supports that ECMR activation is critical for development of vascular and cardiac fibrosis and stiffening. However, the role of ECMR activation...
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Published on Jan 1, 2019in Diabetes 7.27
Guanghong Jia18
Estimated H-index: 18
(University of Missouri),
James R. Sowers83
Estimated H-index: 83
The obesity epidemic is one of the most serious public health problems in the world. Today, about two out of three adults (69%) are overweight or obese in the U.S. In healthy persons, peripheral subcutaneous fat tissue makes up 80% of total body fat (1), and another 10% of adipose tissue is present as either abdominal visceral fat tissue or that in and around organs, including the vasculature, heart, and skeletal muscle (2). Skeletal muscle is the primary site of glucose uptake and is responsibl...
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Published on Jan 1, 2019
Guido Lastra23
Estimated H-index: 23
,
Inga Harbuz-Miller + 1 AuthorsCamila Manrique24
Estimated H-index: 24
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Published on Nov 1, 2018in Pharmacology & Therapeutics 10.38
Yingmei Zhang19
Estimated H-index: 19
(Fudan University),
Adam Whaley-Connell44
Estimated H-index: 44
(University of Missouri)
+ 1 AuthorsJun Ren57
Estimated H-index: 57
(Fudan University)
Abstract Although advances in medical technology and health care have improved the early diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity, insulin resistance, diabetes, hypertension, dyslipidemia, and kidney disease remains high. Findings from numerous population-based studies, clinical trials, and experimental evidence have consolidated a number of theories for the pathogenesis of cardiorenal metabolic anomalies including resistance to the metabolic action...
11 Citations Source Cite
Published on Oct 1, 2018in Trends in Endocrinology and Metabolism 10.77
Jun Ren57
Estimated H-index: 57
(Fudan University),
James R. Sowers83
Estimated H-index: 83
(University of Missouri),
Yingmei Zhang1
Estimated H-index: 1
(Fudan University)
Recent advances in health care have improved the management of cardiometabolic disorders, and prolonged lifespan. However, the ever-rising prevalence of metabolic stress related to obesity (insulin resistance, diabetes, hypertension, and dyslipidemia) has greatly challenged geriatric care. The ubiquitin–proteasome system and autophagy–lysosomal pathways represent two major, yet distinct cellular machineries, for degradation and removal of damaged or long-lived proteins and organelles; the functi...
9 Citations Source Cite
Published on Sep 1, 2018in Hypertension 6.82
Annayya R. Aroor29
Estimated H-index: 29
(University of Missouri),
Javad Habibi36
Estimated H-index: 36
(University of Missouri)
+ 5 AuthorsAdam Whaley-Connell44
Estimated H-index: 44
(University of Missouri)
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Published on Sep 1, 2018in Hypertension 6.82
Guanghong Jia18
Estimated H-index: 18
,
Annayya R. Aroor29
Estimated H-index: 29
+ 1 AuthorsJames R. Sowers83
Estimated H-index: 83
2 Citations Source Cite
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