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James R. Sowers
University of Missouri
762Publications
78H-index
29.8kCitations
Publications 762
Newest
Published on Jan 1, 2019in Diabetes 7.27
Guanghong Jia18
Estimated H-index: 18
(University of Missouri),
James R. Sowers78
Estimated H-index: 78
The obesity epidemic is one of the most serious public health problems in the world. Today, about two out of three adults (69%) are overweight or obese in the U.S. In healthy persons, peripheral subcutaneous fat tissue makes up 80% of total body fat (1), and another 10% of adipose tissue is present as either abdominal visceral fat tissue or that in and around organs, including the vasculature, heart, and skeletal muscle (2). Skeletal muscle is the primary site of glucose uptake and is responsibl...
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Published on Sep 1, 2018in Hypertension 6.82
Guanghong Jia18
Estimated H-index: 18
(University of Missouri),
Habibi Javad (University of Missouri)+ 5 AuthorsJames R. Sowers78
Estimated H-index: 78
(University of Missouri)
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Published on Sep 1, 2018in Hypertension 6.82
Annayya R. Aroor28
Estimated H-index: 28
(University of Missouri),
Guanghong Jia18
Estimated H-index: 18
(University of Missouri)
+ 8 AuthorsFrederic Jaisser30
Estimated H-index: 30
(Paris Descartes University)
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Published on Sep 1, 2018in Hypertension 6.82
Annayya R. Aroor28
Estimated H-index: 28
(University of Missouri),
Javad Habibi35
Estimated H-index: 35
(University of Missouri)
+ 5 AuthorsAdam Whaley-Connell43
Estimated H-index: 43
(University of Missouri)
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Published on Jan 1, 2018in CardioRenal Medicine 2.22
Haroon Kamran9
Estimated H-index: 9
,
Eric Kupferstein + 7 AuthorsSamy I. McFarlane22
Estimated H-index: 22
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Published on Aug 1, 2018in Metabolism-clinical and Experimental 5.96
Tianyi Qiu (University of Missouri), Min Li18
Estimated H-index: 18
(University of Missouri)
+ 4 AuthorsMichael A. Hill40
Estimated H-index: 40
(University of Missouri)
Abstract Background Accumulation of multiple subtypes of immune cells in perivascular adipose tissue (PVAT) has been proposed to cause vascular inflammation and dysfunction in type 2 diabetes (T2DM). This study was designed to investigate specific roles for dendritic cells in PVAT in the development of vascular inflammation and impaired PVAT-mediated vasorelaxation in T2DM. Methods and Results Studies were performed using db/db mice (model of T2DM) and their Db heterozygote (DbHET), lean and nor...
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Published on Apr 13, 2018in American Journal of Hypertension 3.05
Darshan Khangura1
Estimated H-index: 1
(University of Missouri),
L. Romayne Kurukulasuriya9
Estimated H-index: 9
(University of Missouri)
+ 1 AuthorsJames R. Sowers78
Estimated H-index: 78
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Published on Feb 16, 2018in Circulation Research 15.21
Guanghong Jia18
Estimated H-index: 18
,
Michael A. Hill40
Estimated H-index: 40
,
James R. Sowers78
Estimated H-index: 78
Heart failure and related morbidity and mortality are increasing at an alarming rate, in large part, because of increases in aging, obesity, and diabetes mellitus. The clinical outcomes associated with heart failure are considerably worse for patients with diabetes mellitus than for those without diabetes mellitus. In people with diabetes mellitus, the presence of myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascu...
40 Citations Source Cite
Published on Jun 1, 2018in Nature Reviews Endocrinology 20.27
Yingmei Zhang18
Estimated H-index: 18
(Fudan University),
James R. Sowers78
Estimated H-index: 78
(University of Missouri),
Jun Ren55
Estimated H-index: 55
(Fudan University)
Obesity poses a severe threat to human health, including the increased prevalence of hypertension, insulin resistance, diabetes mellitus, cancer, inflammation, sleep apnoea and other chronic diseases. Current therapies focus mainly on suppressing caloric intake, but the efficacy of this approach remains poor. A better understanding of the pathophysiology of obesity will be essential for the management of obesity and its complications. Knowledge gained over the past three decades regarding the ae...
22 Citations Source Cite
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