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Clemens Fürnsinn
Medical University of Vienna
73Publications
24H-index
2,028Citations
Publications 72
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#1Martina Theresa Hackl (Medical University of Vienna)H-Index: 3
#2Clemens Fürnsinn (Medical University of Vienna)H-Index: 24
Last.Thomas Scherer (Medical University of Vienna)H-Index: 17
view all 14 authors...
Hepatic steatosis develops when lipid influx and production exceed the liver’s ability to utilize/export triglycerides. Obesity promotes steatosis and is characterized by leptin resistance. A role of leptin in hepatic lipid handling is highlighted by the observation that recombinant leptin reverses steatosis of hypoleptinemic patients with lipodystrophy by an unknown mechanism. Since leptin mainly functions via CNS signaling, we here examine in rats whether leptin regulates hepatic lipid flux vi...
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#1Zsuzsanna Lehner (Medical University of Vienna)H-Index: 2
#2Karin Stadlbauer (Medical University of Vienna)H-Index: 4
Last.Clemens Fürnsinn (Medical University of Vienna)H-Index: 24
view all 10 authors...
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#1Sameer Abu Eid (Medical University of Vienna)H-Index: 1
#2Martina Theresa Hackl (Medical University of Vienna)H-Index: 3
Last.Clemens Fürnsinn (Medical University of Vienna)H-Index: 24
view all 9 authors...
Abstract Blood glucose and the prevalence of diabetes are lower in mountain than lowland dwellers, which could among other factors be due to reduced oxygen availability. To investigate metabolic adaptations to life under hypoxia, male mice on high fat diet (HFD) were continuously maintained at 10% O2. At variance to preceding studies, the protocol was designed to dissect direct metabolic effects from such mediated indirectly via hypoxia-induced reductions in appetite and weight gain. This was ac...
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#1Karin Stadlbauer (Medical University of Vienna)H-Index: 4
#2Barbara Brunmair (Medical University of Vienna)H-Index: 10
Last.Clemens Fürnsinn (Medical University of Vienna)H-Index: 24
view all 8 authors...
Aims 55P0251 is a novel compound with blood glucose lowering activity in mice, which has been developed from a molecular backbone structure found in herbal remedies. We here report its basic pharmacological attributes and initial progress in unmasking the mode of action. Materials and methods Pharmacokinetic properties of 55P0251 were portrayed in several species. First efforts to elucidate the glucose lowering mechanism in rodents included numerous experimental protocols dealing with glucose to...
1 CitationsSource
5 CitationsSource
#1Sameer Abu Eid (Medical University of Vienna)H-Index: 1
#2Michael Adams (Zürcher Fachhochschule)H-Index: 1
Last.Clemens Fürnsinn (Medical University of Vienna)H-Index: 24
view all 9 authors...
Emodin is found in remedies from Traditional Chinese Medicine. Since antihyperglycaemic action was observed in rodents, non-scientific sources advertise emodin intake as a natural cure for diabetes. Emodin was admixed to high fat-food of obese mice at two doses (2 and 5 g/kg; daily emodin uptake 103 and 229 mg/kg). Comparison was made to ad libitum fed and to food restricted control groups, the latter showing the same weight gain as the corresponding emodin-treated groups. Emodin blunted food in...
3 CitationsSource
#1Cécile Philippe (Medical University of Vienna)H-Index: 13
#2Daniela Haeusler (Medical University of Vienna)H-Index: 14
Last.Markus Mitterhauser (Medical University of Vienna)H-Index: 29
view all 10 authors...
Background The melanin-concentrating hormone receptor 1 (MCHR1), which is highly expressed in the lateral hypothalamus, plays a key role in energy homeostasis, obesity and other endocrine diseases. Hence, there is a major interest in in vivo imaging of this receptor. A PET tracer would allow non-invasive in vivo visualization and quantification of the MCHR1. The aim of the study was the ex vivo evaluation of the MCHR1 ligand [18F]FE@SNAP as a potential PET tracer for the MCHR1.
4 CitationsSource
#1Thomas Scherer (Medical University of Vienna)H-Index: 17
#2Claudia Lindtner (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 11
Last.Christoph Buettner (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 27
view all 13 authors...
Hepatic steatosis is common in obesity and insulin resistance and results from a net retention of lipids in the liver. A key mechanism to prevent steatosis is to increase secretion of triglycerides (TG) packaged as very low–density lipoproteins (VLDL). Insulin controls nutrient partitioning via signaling through its cognate receptor in peripheral target organs such as liver, muscle and adipose tissue and via signaling in the CNS to orchestrate organ cross talk. While hepatic insulin signaling is...
18 CitationsSource
#1Peter Wolf (Medical University of Vienna)H-Index: 8
#2Yvonne Winhofer (Medical University of Vienna)H-Index: 11
Last.Michael Krebs (Medical University of Vienna)H-Index: 30
view all 12 authors...
Abstract Background and Aim Type 2 diabetes (T2DM) is closely associated with the development of heart failure, which might be related with impaired substrate metabolism and accumulation of myocardial lipids (MYCL). The aim of this study was to investigate the impact of an acute pharmacological inhibition of adipose tissue lipolysis leading to reduced availability of circulating FFA on MYCL and heart function in T2DM. Methods and Results 8 patients with T2DM (Age: 56 ± 11; BMI: 28 ± 3.5 kg/m 2 ;...
10 CitationsSource
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