Match!
Zhen Zhang
Harbin Medical University
PathologyIntracerebral hemorrhageMeningiomaHeme oxygenaseMedicine
5Publications
4H-index
92Citations
What is this?
Publications 5
Newest
#1Zhen Zhang (HMU: Harbin Medical University)H-Index: 4
#2Ze Zhang (HMU: Harbin Medical University)H-Index: 2
Last. Jianbo Wang (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 37
view all 6 authors...
Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and morbidity. When a diseased artery within the brain bursts, expansion and absorption of the resulting hematoma trigger a series of reactions that cause primary and secondary brain injury. Microglia are extremely important for removing the hematoma and clearing debris, but they are also a source of ongoing inflammation. This article discusses the role of microglial activation/polarization and related inflammatory mediato...
52 CitationsSource
#1Zhen Zhang (HMU: Harbin Medical University)H-Index: 4
#2Yuejia Song (HMU: Harbin Medical University)H-Index: 7
Last. Jianbo Wang (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 37
view all 11 authors...
Intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and mortality. Heme oxygenase-1 (HO-1), the key enzyme in heme degradation, is highly expressed after ICH, but its role is still unclear. In this study, we used an HO-1 inducer and inhibitor to test the role of HO-1 in different stages of ICH in vivo and in vitro. In the early stage of ICH, high HO-1 expression worsened the outcomes of mice subjected to the collagenase-induced ICH model. HO-1 increased brain edema...
27 CitationsSource
#1Hongmei Meng (HMU: Harbin Medical University)H-Index: 1
#2Yuejia Song (HMU: Harbin Medical University)H-Index: 7
Last. He Wu (HMU: Harbin Medical University)H-Index: 2
view all 10 authors...
: Stroke is a life-threatening disease that results in significant disability in the human population. Despite the advances in current stroke therapies, a host of patients do not benefit from the conventional treatments. Thus, more effective therapies are required. It has been previously reported that leucine‑rich‑α2‑glycoprotein 1 (LRG1) is crucial during the formation of new blood vessels in retinal diseases. However, the function of LRG1 in the brain during the neovessel growth process follow...
7 CitationsSource
#1Jie Jiang (HMU: Harbin Medical University)H-Index: 2
#2Yuejia Song (HMU: Harbin Medical University)H-Index: 7
Last. Jiping Qi (HMU: Harbin Medical University)H-Index: 11
view all 9 authors...
BACKGROUND: Meningiomas account for approximately 24-30% of primary intracranial neoplasms. Histopathologic grade and degree of resection are two major prognostic factors. The aim of this study was to determine the factors associated with the prognosis of meningioma. METHODS: We used immunohistochemistry to analyze the expression levels of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in 287 meningiomas of all grades. RESULTS: The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki- 67 significantly ...
1 CitationsSource
#1Jie Jiang (HMU: Harbin Medical University)H-Index: 2
#2Chengjun Lin (HMU: Harbin Medical University)H-Index: 1
Last. Jiping Qi (HMU: Harbin Medical University)H-Index: 11
view all 7 authors...
The expression of fatty acid metabolism-associated proteins is correlated with the prognosis of meningiomas. Meningioma is a common tumor of the nervous system; however, reliable prognostic markers for meningioma are currently insufficient. High fatty acid synthase (FAS) expression occurs in many tumors, and is associated with tumor progression and grade. Few studies have previously investigated fatty acid metabolism in meningioma; thus, in this study, we investigated the expression of FAS and b...
5 CitationsSource
1