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Adrianna Douvris
University of Ottawa
HemodialysisKidney diseaseRenal replacement therapyAcute kidney injuryMedicine
5Publications
2H-index
41Citations
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Publications 5
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#1Adrianna Douvris (U of O: University of Ottawa)H-Index: 2
#2Khalid Zeid (U of O: University of Ottawa)H-Index: 1
Last. Edward G. Clark (U of O: University of Ottawa)H-Index: 12
view all 9 authors...
Hemodynamic instability related to renal replacement therapy (HIRRT) is a frequent complication of all renal replacement therapy (RRT) modalities commonly used in the intensive care unit. HIRRT is associated with increased mortality and may impair kidney recovery. Our current understanding of the physiologic basis for HIRRT comes primarily from studies of end-stage kidney disease patients on maintenance hemodialysis in whom HIRRT is referred to as ‘intradialytic hypotension’. Nonetheless, there ...
2 CitationsSource
#1Adrianna DouvrisH-Index: 2
#2Khalid ZeidH-Index: 1
Last. Edward G. ClarkH-Index: 12
view all 8 authors...
Background: Safety lapses in hospitalized patients with acute kidney injury (AKI) may lead to hemodialysis (HD) being required before renal recovery might have otherwise occurred. We sought to identify safety lapses that, if prevented, could reduce the need for unnecessary HD after AKI; Methods: We conducted a retrospective observational study that included consecutive patients treated with HD for AKI at a large, tertiary academic center between 1 September 2015 and 31 August 2016. Exposures of ...
1 CitationsSource
#1Adrianna Douvris (U of O: University of Ottawa)H-Index: 2
#2Gurpreet Malhi (U of O: University of Ottawa)H-Index: 1
Last. Edward G. Clark (Ottawa Hospital Research Institute)H-Index: 12
view all 11 authors...
Background Hemodynamic instability related to renal replacement therapy (HIRRT) may increase the risk of death and limit renal recovery. Studies in end-stage renal disease populations on maintenance hemodialysis suggest that some renal replacement therapy (RRT)-related interventions (e.g., cool dialysate) may reduce the occurrence of HIRRT, but less is known about interventions to prevent HIRRT in critically ill patients receiving RRT for acute kidney injury (AKI). We sought to evaluate the effe...
8 CitationsSource
#1Adrianna Douvris (U of O: University of Ottawa)H-Index: 2
#2Swapnil Hiremath (Ottawa Hospital Research Institute)H-Index: 21
Last. Edward G. Clark (Ottawa Hospital Research Institute)H-Index: 12
view all 6 authors...
Background Hemodynamic instability during renal replacement therapy (HIRRT) in the form of intradialytic hypotension (IDH) is a frequent complication of hemodialysis in end-stage kidney disease (ESKD), and most studies have focused on this chronic population. However, HIRRT is also an important concern for critically ill ICU patients with acute kidney injury (AKI), complicating an estimated 30% of dialysis treatments in this population. HIRRT can exacerbate organ hypoperfusion in the setting of ...
2 CitationsSource
#1Adrianna Douvris (U of O: University of Ottawa)H-Index: 2
#2Sébastien Soubeyrand (U of O: University of Ottawa)H-Index: 11
Last. Ruth McPherson (U of O: University of Ottawa)H-Index: 72
view all 9 authors...
Background-—The TRIB1 locus has been linked to hepatic triglyceride metabolism in mice and to plasma triglycerides and coronary artery disease in humans. The lipid-associated single nucleotide polymorphisms (SNPs), identified by genome-wide association studies, are located � 30 kb downstream from TRIB1, suggesting complex regulatory effects on genes or pathways relevant to hepatic triglyceride metabolism. The goal of this study was to investigate the functional relationship between common SNPs a...
30 CitationsSource
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