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Hongwen He
Sun Yat-sen University
Trigeminal ganglionNitric oxide synthaseMelatoninNitric oxideBiology
32Publications
10H-index
295Citations
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Publications 36
Newest
#1Miaomiao Zheng (SYSU: Sun Yat-sen University)
#2Fuping Zhang (SYSU: Sun Yat-sen University)H-Index: 1
Last. Hongwen He (SYSU: Sun Yat-sen University)H-Index: 10
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N-Acetyl-5-methoxytryptamine (melatonin, MT) at pharmacological concentrations promotes the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells; however, its role at physiological concentrations (1 pM-10 nM) remains unclear. We explored the effects of 1 pM-1 microM MT on the osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and its underlying mitochondrial dynamics-mediated mechanisms. T he PDLSC phenotype was detected by flow cytometry and ...
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#2Wenguo FanH-Index: 10
Last. Fang HuangH-Index: 9
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Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms. Melatonin is involved in many physiological and pathophysiological processes demonstrating antioxidant, antineoplastic, anti-inflammatory, and immunomodulatory properties. Accumulating evidence has revealed that melatonin plays an important role in pain modulation through multiple mechanisms. In this review, we examine rece...
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#1Qianyi Deng (SYSU: Sun Yat-sen University)H-Index: 2
#2Qin Liu (SYSU: Sun Yat-sen University)H-Index: 3
Last. Fang Huang (SYSU: Sun Yat-sen University)H-Index: 9
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Abstract Background/purpose Melatonin, at physiological concentrations, was previously found to inhibit proliferation and promote odontogenic differentiation in human dental pulp cells (hDPCs), but its effect on apoptosis is unclear. Our study aimed to investigate the effect of melatonin on the H2O2-mediated viability reduction and apoptosis in hDPCs. Materials and methods hDPCs were treated with H2O2 (0, 250, 500, 1000 μmol/L), melatonin (0, 10−12, 10−10, 10−8 mol/L), and melatonin with H2O2 fo...
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#1Yifan He (SYSU: Sun Yat-sen University)H-Index: 2
#2Wenguo Fan (SYSU: Sun Yat-sen University)H-Index: 10
Last. Fang Huang (SYSU: Sun Yat-sen University)H-Index: 9
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#1Wenguo Fan (SYSU: Sun Yat-sen University)H-Index: 10
#2Xiao ZhuH-Index: 2
Last. Hongwen He (SYSU: Sun Yat-sen University)H-Index: 10
view all 7 authors...
1 CitationsSource
#1Huini Zhang (SYSU: Sun Yat-sen University)
#2Qianyi Deng (SYSU: Sun Yat-sen University)H-Index: 2
Last. Fang Huang (SYSU: Sun Yat-sen University)H-Index: 9
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#1Jun Kang (SYSU: Sun Yat-sen University)H-Index: 1
#2Wenguo Fan (SYSU: Sun Yat-sen University)H-Index: 10
Last. Fang Huang (SYSU: Sun Yat-sen University)H-Index: 9
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Stem cells are biological cells that can self-renew and can differentiate into multiple cell lineages. Stem cell-based therapy is emerging as a promising alternative therapeutic option for various disorders. Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are isolated from various tissues and can be used as an alternative to embryonic stem cells. Stem cells from the apical papilla (SCAPs) are a novel population of MSCs residing in the apical papilla of immature permanent teet...
2 CitationsSource
#1Wenguo FanH-Index: 10
#2Xiao ZhuH-Index: 2
Last. Hongwen HeH-Index: 10
view all 7 authors...
1 CitationsSource
#1Wenguo Fan (SYSU: Sun Yat-sen University)H-Index: 10
#2Yifan HeH-Index: 2
Last. Hongwen HeH-Index: 10
view all 8 authors...
Abstract Melatonin is a hormone mainly synthesized by the pineal gland in vertebrates and known well as an endogenous regulator of circadian and seasonal rhythms. It has been demonstrated that melatonin is involved in many physiological and pathophysiological processes showing antioxidant, anti-apoptotic and anti-inflammatory properties. Nitric oxide (NO) is a free radical gas in the biological system, which is produced by nitric oxide synthase (NOS) family. NO acts as a biological mediator and ...
2 CitationsSource
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