Match!
Fei Wang
Tianjin Medical University
5Publications
3H-index
88Citations
Publications 5
Newest
#1Fei Wang (Tianjin Medical University)H-Index: 3
#2Yu GengH-Index: 1
Last.XinGeng (Tianjin Medical University)H-Index: 5
view all 4 authors...
To identify Zinc-alpha-2-glycoprotein (ZAG) expression in HCC for serum biomarker, by analyzing the serum proteome of the patients suffering from primary hepatocellular carcinoma (HCC), liver cirrhosis and healthy donors. The serum proteome of the patients from HCC, liver cirrhosis and healthy donors were separated and identified by two-dimensional electrophoresis. The differentially expressed proteins were analyzed by peptide mass fingerprint based on MALDI-TOF-MS and SWISS-PROT or BLAST nr dat...
3 CitationsSource
#1Fei Wang (Tianjin Medical University)H-Index: 3
#2Yu GengH-Index: 1
Last.XinGeng (Tianjin Medical University)H-Index: 5
view all 4 authors...
To Analyze the structure and function of Zinc-alpha-2-glycoprotein (ZAG), a highly expressed serum protein in the patients with hepatocellular carcinoma (HCC). The serum proteome of the patients from HCC, liver cirrhosis and healthy donors were separated and identified by two-dimensional electrophoresis and MALDI-TOF-MS. RT-PCR and Western blotting analysis were used to confirm ZAG highly expressed in HCC. Bioinformatics technologies were used to analyze the structure character of ZAG protein. F...
1 CitationsSource
#1Jin LuoH-Index: 1
#2Yanni LiH-Index: 1
Last.XinGengH-Index: 5
view all 5 authors...
A global DNA hypomethylation might activate oncogene transcription, thus promoting carcinogenesis and tumor development. S-Adenosylmethionine (SAM) serves as a major methyl donor in biological transmethylation events. The object of this study is to explore the influence of SAM on the status of methylation at the promoter of the oncogenes c-myc, H-ras and tumor-suppressor gene p16 (INK4a), as well as its inhibitory effect on cancer cells. The results indicated that SAM treatment inhibited cell gr...
60 CitationsSource
#1Xin-Qing PengH-Index: 1
#2Fei Wang (Tianjin Medical University)H-Index: 3
Last.Wei-Ming Zhang (Tianjin Medical University)H-Index: 1
view all 4 authors...
Tumor proteomics apply proteomics techniques to tumor biological research, mainly by screening candidate biomarkers for early tumor diagnosis, prognosis and treatment. Hepatocellular carcinoma (HCC) is a type of malignant tumor with one of the highest death rates in the world. With the advent of the post-genomic age, tumor biological research developing the technology of proteomics has become a major focus of researchers. The discovery of novel candidate biomarkers is one of crucial problems for...
14 CitationsSource
#1XinGeng (Tianjin Medical University)H-Index: 5
#2Fei Wang (Tianjin Medical University)H-Index: 3
Last.Wei Ming Zhang (Tianjin Medical University)H-Index: 2
view all 4 authors...
Aims and background. The mechanism of human MutL Homolog (HMLH1) gene transcriptional inactivation in non-small cell lung cancer (NSCLC) is still unclear. The aim of this study is to further investigate the main mechanism of HMLH1 gene inactivation in NSCLC samples of Chinese patients. Methods and study design. This study was performed in surgically resected primary tumor and matched normal tissues from 116 NSCLC cases. The hMLH1 gene alterations examined included loss of heterozygosity (LOH) by...
10 CitationsSource
1