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Bo Isomaa
Lund University
99Publications
45H-index
25.1kCitations
Publications 99
Newest
Published on Apr 1, 2018in Nature Genetics 27.13
Anubha Mahajan35
Estimated H-index: 35
(Wellcome Trust Centre for Human Genetics),
Jennifer Wessel19
Estimated H-index: 19
(Indiana University – Purdue University Indianapolis)
+ 237 AuthorsN. William Rayner19
Estimated H-index: 19
(University of Oxford)
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10−7); of these, 16 map outside known risk-associated loci. We make two important observations. First, only five of these signals are driven by low-frequency variants: even for these, effect sizes are modest (odds ratio ≤1.29). Second, when we used large-scale genome-wide association data to fine-map the associated variants in t...
24 Citations Source Cite
Published on Feb 1, 2018in Human Molecular Genetics 4.90
Anke Tönjes40
Estimated H-index: 40
(Leipzig University),
Markus Scholz29
Estimated H-index: 29
(Leipzig University)
+ 26 AuthorsClaes Ladenvall24
Estimated H-index: 24
(Lund University)
Progranulin is a secreted protein with important functions in processes including immune and inflammatory response, metabolism and embryonic development. The present study aimed at identification of genetic factors determining progranulin concentrations. We conducted a genome-wide association meta-analysis for serum progranulin in three independent cohorts from Europe: Sorbs (N=848) and KORA (N=1628) from Germany and PPP-Botnia (N=335) from Finland (total N=2811). Single nucleotide polymorphisms...
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Published on Apr 1, 2018in European Journal of Endocrinology 4.33
Barbara Di Camillo16
Estimated H-index: 16
,
Liisa Hakaste5
Estimated H-index: 5
(University of Helsinki)
+ 10 AuthorsAndrea Facchinetti25
Estimated H-index: 25
OBJECTIVE: Type 2 diabetes arises from the interaction of physiological and lifestyle risk factors. Our objective was to develop a model for predicting the risk of T2D, which could use various amounts of background information.RESEARCH DESIGN AND METHODS: We trained a survival analysis model on 8483 people from three large Finnish and Spanish data sets, to predict the time until incident T2D. All studies included anthropometric data, fasting laboratory values, an oral glucose tolerance test (OGT...
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Published on Feb 6, 2018
Jason Flannick28
Estimated H-index: 28
,
Christian Fuchsberger39
Estimated H-index: 39
+ 298 AuthorsLoukas Moutsianas17
Estimated H-index: 17
Published on Jan 1, 2018
Anubha Mahajan35
Estimated H-index: 35
,
Jennifer Wessel19
Estimated H-index: 19
+ 237 AuthorsN. William Rayner19
Estimated H-index: 19
Published on Sep 12, 2018in Annals of Medicine 3.01
Kadri Haljas2
Estimated H-index: 2
(University of Helsinki),
Jari Lahti43
Estimated H-index: 43
(University of Helsinki)
+ 4 AuthorsKatri Räikkönen50
Estimated H-index: 50
(University of Helsinki)
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Published on Dec 28, 2018in Annals of Medicine 3.01
Kadri Haljas2
Estimated H-index: 2
(University of Helsinki),
Liisa Hakaste5
Estimated H-index: 5
(University of Helsinki)
+ 4 AuthorsKatri Räikkönen50
Estimated H-index: 50
(University of Helsinki)
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Published on Nov 7, 2017
Robert A. Scott43
Estimated H-index: 43
,
Laura J. Scott55
Estimated H-index: 55
+ 172 AuthorsJohn D. Eicher16
Estimated H-index: 16
Published on Dec 19, 2017in Scientific Data 5.31
Flannick Jason1
Estimated H-index: 1
(Harvard University),
Christian Fuchsberger39
Estimated H-index: 39
(University of Michigan)
+ 298 AuthorsLoukas Moutsianas17
Estimated H-index: 17
(University of Oxford)
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and e ...
5 Citations Source Cite
Published on Dec 19, 2017
Jason Flannick28
Estimated H-index: 28
,
Christian Fuchsberger39
Estimated H-index: 39
+ 298 AuthorsLoukas Moutsianas17
Estimated H-index: 17
5 Citations Source Cite
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