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Bo Isomaa
Lund University
100Publications
46H-index
23.9kCitations
Publications 100
Newest
Published on Jan 2, 2019in Annals of Medicine 3.01
Kadri Haljas2
Estimated H-index: 2
(University of Helsinki),
Liisa Hakaste4
Estimated H-index: 4
(University of Helsinki)
+ 4 AuthorsKatri Räikkönen48
Estimated H-index: 48
(University of Helsinki)
AbstractBackground: Seasonal variation in glucose metabolism might be driven by changes in daylight. Melatonin entrains circadian regulation and is directly associated with daylight. The relationship between melatonin receptor 1B gene variants with glycemic traits and type 2 diabetes is well established. We studied if daylight length was associated with glycemic traits and if it modified the relationship between melatonin receptor 1B gene rs10830963 variant and glycemic traits.Materials: A popul...
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Published on Nov 17, 2018in Annals of Medicine 3.01
Kadri Haljas2
Estimated H-index: 2
(University of Helsinki),
Jari Lahti46
Estimated H-index: 46
(University of Helsinki)
+ 4 AuthorsKatri Räikkönen48
Estimated H-index: 48
(University of Helsinki)
AbstractBackground: The association between depression and type 2 diabetes is bidirectional. Underlying biological determinants remain elusive. We examined whether a common melatonin receptor 1B gene diabetes risk variant rs10830963 influenced the associations between depressive symptoms and glycaemic traits.Materials: The Prevalence, Prediction and Prevention of Diabetes-Botnia Study participants (n = 4,455) with no diabetes who underwent an oral glucose tolerance test were genotyped for rs1083...
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Published on Apr 1, 2018in Nature Genetics 27.13
Anubha Mahajan42
Estimated H-index: 42
(Wellcome Trust Centre for Human Genetics),
Jennifer Wessel21
Estimated H-index: 21
(Indiana University – Purdue University Indianapolis)
+ 237 AuthorsN. William Rayner21
Estimated H-index: 21
(University of Oxford)
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10−7); of these, 16 map outside known risk-associated loci. We make two important observations. First, only five of these signals are driven by low-frequency variants: even for these, effect sizes are modest (odds ratio ≤1.29). Second, when we used large-scale genome-wide association data to fine-map the associated variants in t...
43 Citations Source Cite
Published on Apr 1, 2018in European Journal of Endocrinology 4.33
Barbara Di Camillo18
Estimated H-index: 18
,
Liisa Hakaste4
Estimated H-index: 4
(University of Helsinki)
+ 10 AuthorsAndrea Facchinetti25
Estimated H-index: 25
OBJECTIVE: Type 2 diabetes arises from the interaction of physiological and lifestyle risk factors. Our objective was to develop a model for predicting the risk of T2D, which could use various amounts of background information.RESEARCH DESIGN AND METHODS: We trained a survival analysis model on 8483 people from three large Finnish and Spanish data sets, to predict the time until incident T2D. All studies included anthropometric data, fasting laboratory values, an oral glucose tolerance test (OGT...
3 Citations Source Cite
Published on Feb 6, 2018
Jason Flannick31
Estimated H-index: 31
,
Christian Fuchsberger40
Estimated H-index: 40
+ 298 AuthorsLoukas Moutsianas20
Estimated H-index: 20
Published on Feb 1, 2018in Human Molecular Genetics 4.90
Anke Tönjes51
Estimated H-index: 51
(Leipzig University),
Markus Scholz32
Estimated H-index: 32
(Leipzig University)
+ 26 AuthorsClaes Ladenvall24
Estimated H-index: 24
(Lund University)
Progranulin is a secreted protein with important functions in processes including immune and inflammatory response, metabolism and embryonic development. The present study aimed at identification of genetic factors determining progranulin concentrations. We conducted a genome-wide association meta-analysis for serum progranulin in three independent cohorts from Europe: Sorbs (N=848) and KORA (N=1628) from Germany and PPP-Botnia (N=335) from Finland (total N=2811). Single nucleotide polymorphisms...
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Published on Jan 1, 2018
Anubha Mahajan42
Estimated H-index: 42
,
Jennifer Wessel21
Estimated H-index: 21
+ 237 AuthorsN. William Rayner21
Estimated H-index: 21
Published on Jan 1, 2018
Kadri Haljas2
Estimated H-index: 2
,
Jari Lahti46
Estimated H-index: 46
+ 4 AuthorsKatri Räikkönen48
Estimated H-index: 48
Published on Dec 19, 2017
Jason Flannick31
Estimated H-index: 31
,
Christian Fuchsberger40
Estimated H-index: 40
+ 298 AuthorsLoukas Moutsianas20
Estimated H-index: 20
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Published on Dec 19, 2017in Scientific Data 5.31
Flannick Jason1
Estimated H-index: 1
(Harvard University),
Christian Fuchsberger40
Estimated H-index: 40
(University of Michigan)
+ 298 AuthorsLoukas Moutsianas20
Estimated H-index: 20
(University of Oxford)
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and e ...
2 Citations Source Cite
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