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Hedok Lee
Stony Brook University
38Publications
14H-index
943Citations
Publications 38
Newest
Published on Feb 5, 2019in arXiv: Fluid Dynamics2.44
Rena Elkin1
Estimated H-index: 1
,
Saad Nadeem3
Estimated H-index: 3
+ 2 AuthorsAllen R. Tannenbaum58
Estimated H-index: 58
In this work, a unified representation of all the time-varying dynamics is accomplished with a Lagrangian framework for analyzing regularized dynamical optimal mass transport (OMT) derived flows. Our Lagrangian framework is also applicable to the Fisher-Rao regularization because, as we show, it is equivalent to our regularized dynamical OMT formulation. The advantage of the Lagrangian framework is that the time-varying trajectories and particle attributes are displayed in a single visualization...
Rena Elkin1
Estimated H-index: 1
,
Saad Nadeem3
Estimated H-index: 3
+ -3 AuthorsAllen R. Tannenbaum58
Estimated H-index: 58
The glymphatic system (GS) is a transit passage that facilitates brain metabolic waste removal and its dysfunction has been associated with neurodegenerative diseases such as Alzheimer's disease. The GS has been studied by acquiring temporal contrast enhanced magnetic resonance imaging (MRI) sequences of a rodent brain, and tracking the cerebrospinal fluid injected contrast agent as it flows through the GS. We present here a novel visualization framework, GlympVIS, which uses regularized optimal...
Published on Jul 1, 2018in Anesthesiology6.42
Rany Makaryus6
Estimated H-index: 6
,
Hedok Lee14
Estimated H-index: 14
+ 2 AuthorsHelene Benveniste37
Estimated H-index: 37
BACKGROUND:Potential deleterious effect of multiple anesthesia exposures on the developing brain remains a clinical concern. We hypothesized that multiple neonatal anesthesia exposures are more detrimental to brain maturation than an equivalent single exposure, with more pronounced long-term behavioral consequences. We designed a translational approach using proton magnetic resonance spectroscopy in rodents, noninvasively tracking the neuronal marker N-acetyl-aspartate, in addition to tracking b...
Published on Dec 1, 2017in Anesthesiology6.42
Helene Benveniste37
Estimated H-index: 37
,
Hedok Lee14
Estimated H-index: 14
+ 6 AuthorsHanbing Lu16
Estimated H-index: 16
The glymphatic pathway transports cerebrospinal fluid through the brain, thereby facilitating waste removal. A unique aspect of this pathway is that its function depends on the state of consciousness of the brain and is associated with norepinephrine activity. A current view is that all anesthetics will increase glymphatic transport by inducing unconsciousness. This view implies that the effect of anesthetics on glymphatic transport should be independent of their mechanism of action, as long as ...
Published on Mar 11, 2016in bioRxiv
Vadim Ratner3
Estimated H-index: 3
(SBU: Stony Brook University),
Yi Gao12
Estimated H-index: 12
(SBU: Stony Brook University)
+ 3 AuthorsAllen R. Tannenbaum58
Estimated H-index: 58
(SBU: Stony Brook University)
It was recently shown that the brain-wide cerebrospinal fluid (CSF) and interstitial fluid exchange system designated the `glymphatic pathway' plays a key role in removing waste products from the brain, similarly to the lymphatic system in other body organs [1,2]. It is therefore important to study the flow patterns of glymphatic transport through the live brain in order to better understand its functionality in normal and pathological states. Unlike blood, the CSF does not flow rapidly through ...
Published on Sep 1, 2015in Anesthesiology6.42
Rany Makaryus6
Estimated H-index: 6
,
Hedok Lee14
Estimated H-index: 14
+ 4 AuthorsHelene Benveniste37
Estimated H-index: 37
BACKGROUND: A wealth of data shows neuronal demise after general anesthesia in the very young rodent brain. Herein, the authors apply proton magnetic resonance spectroscopy (1HMRS), testing the hypothesis that neurotoxic exposure during peak synaptogenesis can be tracked via changes in neuronal metabolites. METHODS: 1HMRS spectra were acquired in the brain (thalamus) of neonatal rat pups 24 and 48 h after sevoflurane exposure on postnatal day (PND) 7 and 15 and in unexposed, sham controls. A rep...
Published on Mar 1, 2015in Journal of Neurology4.20
Oren S. Cohen19
Estimated H-index: 19
(TAU: Tel Aviv University),
Joab Chapman42
Estimated H-index: 42
(TAU: Tel Aviv University)
+ 6 AuthorsHedok Lee14
Estimated H-index: 14
(SBU: Stony Brook University)
Familial Creutzfeldt–Jakob disease (fCJD) in Jews of Libyan ancestry is caused by an E200K mutation in the PRNP gene. While carriers are born with this mutation, they usually remain asymptomatic until middle age. Early detection of conversion is crucial for understanding and eventually for the treatment of the disease. The aim of this study was to report longitudinal MRI data in E200K individuals who eventually converted from healthy mutation carriers to clinically symptomatic CJD. As a part of ...
Published on May 12, 2014in PLOS ONE2.78
June Hee Park2
Estimated H-index: 2
(CSHL: Cold Spring Harbor Laboratory),
Hedok Lee14
Estimated H-index: 14
(SBU: Stony Brook University)
+ 9 AuthorsT. G. Bolwig18
Estimated H-index: 18
(Copenhagen University Hospital)
RATIONALE: Dividing cells can be detected in the live brain by positron emission tomography or optical imaging. Here we apply proton magnetic resonance spectroscopy (1HMRS) and a widely used spectral fitting algorithm to characterize the effect of increased neurogenesis after electroconvulsive shock in the live rodent brain via spectral signatures representing mobile lipids resonating at approximately 1.30 ppm. In addition, we also apply the same 1HMRS methodology to metabolically profile gliobl...
Published on Mar 1, 2014in Neurobiology of Aging4.40
Oren S. Cohen19
Estimated H-index: 19
(Sheba Medical Center),
Joab Chapman42
Estimated H-index: 42
(Sheba Medical Center)
+ 5 AuthorsHedok Lee14
Estimated H-index: 14
(Mount Sinai Hospital)
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