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V. Ferraz-de-Paula
University of São Paulo
38Publications
13H-index
608Citations
Publications 38
Newest
#1Carolina Costola-de-Souza (USP: University of São Paulo)H-Index: 6
#2Atilio Sersun Calefi (USP: University of São Paulo)H-Index: 7
Last.João Palermo-Neto (USP: University of São Paulo)H-Index: 29
view all 9 authors...
A sinalizacao por endocanabinoides e finalizada por meio de hidrolise enzimatica; um processo que para o endocanabinoide 2-Arachidonoylglycerol (2-AG) e mediado pela lipase monoacilglicerol (MAGL). O JZL184 e um farmaco que apresenta alta seletividade na inibicao da MAGL. Assim, o JZL184 aumenta os niveis de 2-AG que, por sua vez, atua sobre os receptores canabinoides CB1 e CB2 produzindo diversos efeitos como, por exemplo, o anti-inflamatorio. A inflamacao pulmonar aguda (ALI) e a sua forma mai...
#1A. Ribeiro (USP: University of São Paulo)H-Index: 12
#2Vinicius Izidio de Almeida (USP: University of São Paulo)H-Index: 3
Last.Wothan Tavares-de-Lima (USP: University of São Paulo)H-Index: 16
view all 10 authors...
AbstractWe have previously shown that the prophylactic treatment with cannabidiol (CBD) reduces inflammation in a model of acute lung injury (ALI). In this work we analyzed the effects of the therapeutic treatment with CBD in mice subjected to the model of lipopolysaccharide (LPS)-induced ALI on pulmonary mechanics and inflammation. CBD (20 and 80 mg/kg) was administered (i.p.) to mice 6 h after LPS-induced lung inflammation. One day (24 h) after the induction of inflammation the assessment of p...
#1V. Ferraz-de-Paula (USP: University of São Paulo)H-Index: 13
#2A. Ribeiro (USP: University of São Paulo)H-Index: 12
Last.João Palermo-Neto (USP: University of São Paulo)H-Index: 29
view all 10 authors...
Ecstasy is the popular name of the abuse drug 3,4-methylenedioxymethamphetamine (MDMA) that decreases immunity in animals. The mechanisms that generate such alterations are still controversial. Seven independent pharmacological approaches were performed in mice to identify the possible mechanisms underlying the decrease of neutrophil activity induced by MDMA and the possible effects of MDMA on host resistance to Listeria monocytogenes. Our data showed that MDMA (10 mg kg−1) administration decrea...
#1Carolina Costola-de-Souza (USP: University of São Paulo)H-Index: 6
#2Atilio Sersun Calefi (USP: University of São Paulo)H-Index: 7
Last.João Palermo-Neto (USP: University of São Paulo)H-Index: 29
view all 9 authors...
Endocannabinoid signaling is terminated by enzymatic hydrolysis; process that 2-Arachidonoylglycerol (2-AG) is mediated by monoacylglycerol lipase (MAGL). The MAGL inhibition increases 2-AG levels, an endocannabinoid that acts on CB1 and CB2 receptors. In inflammation, the neutrophils are the first leukocytes to migrate to the injury focus. The aim was to investigate the effects of MAGL inhibition (with JZL184) in the neutrophils recruitment and activity in a murine model of acute lung injury (A...
#1João Palermo-Neto (USP: University of São Paulo)H-Index: 29
#2W.M. Quinteiro-Filho (USP: University of São Paulo)H-Index: 11
Last.A.V. Gomes (USP: University of São Paulo)H-Index: 3
view all 10 authors...
Overcrowding stress is a reality in the poultry industry. Chickens exposed to long-term stressful situations present a reduction of welfare and immunosuppression. We designed this experiment to analyze the effects of overcrowding stress (16 birds/m 2 ) on performance parameters, serum corticosterone levels, the relative weight of the bursa of Fabricius, plasma IgA and IgG levels, intestinal integrity, macrophage activity and experimental Salmonella Enteritidis invasion. The overcrowding stress d...
#1A.V. Gomes (USP: University of São Paulo)H-Index: 3
#2W.M. Quinteiro-Filho (USP: University of São Paulo)H-Index: 11
Last.João Palermo-Neto (USP: University of São Paulo)H-Index: 29
view all 10 authors...
Overcrowding stress is a reality in the poultry industry. Chickens exposed to long-term stressful situations present a reduction of welfare and immunosuppression. We designed this experiment to analyse the effects from overcrowding stress of 16 birds/m2 on performance parameters, serum corticosterone levels, the relative weight of the bursa of Fabricius, plasma IgA and IgG levels, intestinal integrity, macrophage activity and experimental Salmonella Enteritidis invasion. The results of this stud...
#1Adriano Zager (USP: University of São Paulo)H-Index: 12
#2M.L. Pinheiro (USP: University of São Paulo)H-Index: 12
Last.João Palermo-Neto (USP: University of São Paulo)H-Index: 29
view all 5 authors...
Abstract Early life experiences, particularly during the gestational period, are homeostatic determinants for an individual's brain development. However, recent data suggest that the immune response of the offspring is also affected by events during the gestational period. Here, we evaluated the impact of prenatal immune activation on the innate and adaptive immune responses of adult offspring. Pregnant Swiss mice received saline or lipopolysaccharide (LPS) on gestational day 17. In adulthood, m...
#1Carolina Costola-de-Souza (USP: University of São Paulo)H-Index: 6
#2A. Ribeiro (USP: University of São Paulo)H-Index: 12
Last.João Palermo-Neto (USP: University of São Paulo)H-Index: 29
view all 9 authors...
Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that, for 2-Arachidonoylglycerol (2-AG), is mediated by monoacylglycerol lipase (MAGL). The piperidine carbamate, 4-​nitrophenyl- ​4-​(dibenzo[d] [1,3]dioxol-​5-​yl (hydroxy) methyl) piperidine- 1-​carboxylate (JZL184), is a drug that inhibits MAGL and presents high potency and selectivity. Thus, JZL184 increases the levels of 2-AG, an endocannabinoid that acts on the CB1 and CB2 cannabinoid receptors. Here, we investigat...
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