Michael Jarrett
University of British Columbia
ConcussionMyelinTraumatic brain injuryWhite matterMedicine
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Publications 9
#1Mariya V. Cherkasova (UBC: University of British Columbia)H-Index: 6
#2Jessie Fanglu Fu (UBC: University of British Columbia)H-Index: 3
Last. A. J. Stoessl (UBC: University of British Columbia)
view all 17 authors...
Significant insights have been gained into the neural mechanisms of acute placebo responses. However, little is known about the mechanisms of long-term placebo responses, such as those seen in clinical trials, or the interactions between these mechanisms and brain disease. We examined morphological brain correlates of placebo responses in a randomized clinical trial of the liberation procedure, a controversial endovascular treatment for multiple sclerosis (MS). Patients were randomized to receiv...
#1Jean-Francois Esculier (UBC: University of British Columbia)H-Index: 2
#2Michael Jarrett (UBC: University of British Columbia)H-Index: 3
Last. Michael A. Hunt (UBC: University of British Columbia)H-Index: 34
view all 9 authors...
Abstract Objective Running is an easy way of meeting physical activity recommendations for individuals with knee osteoarthritis (KOA); however, it remains unknown how their cartilage reacts to running. The objective of this pilot study was to compare the effects of 30 min of running on T2 and T1ρ relaxation times of tibiofemoral cartilage in female runners with and without KOA. Methods Ten female runners with symptomatic KOA (mean age 52.6 ± 7.6 years) and 10 without KOA (mean age 52.5 ± 7.8 yea...
#1Hanwen Liu (UBC: University of British Columbia)H-Index: 1
#2Cristina Rubino (UBC: University of British Columbia)H-Index: 3
Last. Cornelia LauleH-Index: 21
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#2Lisa TangH-Index: 11
Last. Vanessa Wiggermann (UBC: University of British Columbia)H-Index: 5
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Abstract Background Accurate segmentation of MS lesions on MRI is difficult and, if performed manually, time consuming. Automatic segmentations rely strongly on the image contrast and signal-to-noise ratio. Literature examining segmentation tool performances in real-world multi-site data acquisition settings is scarce. Objective FLAIR 2 , a combination of T 2 -weighted and fluid attenuated inversion recovery (FLAIR) images, improves tissue contrast while suppressing CSF. We compared the use of F...
#1Alexander M. Weber (UBC: University of British Columbia)H-Index: 6
#2Anna Pukropski (University of Osnabrück)H-Index: 1
Last. Alexander Rauscher (UBC: University of British Columbia)H-Index: 28
view all 8 authors...
Myelin sensitive MRI techniques, such as diffusion tensor imaging and myelin water imaging, have previously been used to reveal changes in myelin after sports-related concussions. What is not clear from these studies, however, is how myelin is affected: whether the it becomes degraded and possibly removed, or whether the myelin sheath loosens and becomes 'decompacted'. Previously, our team revealed myelin specific changes in ice hockey players two weeks post concussion using myelin water imaging...
1 CitationsSource
#1Alexander D Wright (UBC: University of British Columbia)H-Index: 3
#2Michael Jarrett (UBC: University of British Columbia)H-Index: 3
Last. Alexander Rauscher (UBC: University of British Columbia)H-Index: 28
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Impact-related mild traumatic brain injuries (mTBI) are a major public health concern, and remain as one of the most poorly understood injuries in the field of neuroscience. Currently, the diagnosis and management of such injuries are based largely on patient-reported symptoms. An improved understanding of the underlying pathophysiology of mTBI is urgently needed in order to develop better diagnostic and management protocols. Specifically, dynamic post-injury changes to the myelin sheath in the ...
31 CitationsSource
#1Michael Jarrett (UBC: University of British Columbia)H-Index: 3
#2Roger Tam (UBC: University of British Columbia)H-Index: 18
Last. Alexander Rauscher (UBC: University of British Columbia)H-Index: 28
view all 11 authors...
Traumatic brain injury (TBI) is among the most common neurological disorders. Haemorrhagic lesions and white matter hyperintensities (WMH) are radiological features associated with moderate and severe traumatic brain injury TBI. Brain volume reductions have also been observed during the months following injury. In concussion, no signs of injury are observed on conventional MRI, which may be a true feature of concussion or merely due to the limited sensitivity of imaging techniques used so far. M...
21 CitationsSource
#1Rael T. LangeH-Index: 24
#2Jason R. ShewchukH-Index: 7
Last. Grant L. Iverson (Harvard University)H-Index: 67
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The purpose of the study was to disentangle the relative contributions of day-of-injury alcohol intoxication and pre-injury alcohol misuse on outcome from TBI. Participants were 142 patients enrolled from a Level 1 Trauma Center (in Vancouver, Canada) following a traumatic brain injury (TBI; 43 uncomplicated mild TBI and 63 complicated mild-severe TBI) or orthopedic injury [36 trauma controls (TC)]. At 6-8 weeks post-injury, diffusion tensor imaging (DTI) of the whole brain was undertaken using ...
15 CitationsSource