Claire E. Wainwright
University of Queensland
PathologyIntensive care medicineCystic fibrosisPseudomonas aeruginosaMedicine
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Publications 261
#1A. Munck (Paris Diderot University)H-Index: 7
#2Eitan Kerem (HUJI: Hebrew University of Jerusalem)H-Index: 51
Last. Claire E. Wainwright (UQ: University of Queensland)H-Index: 41
view all 8 authors...
Abstract Background Tezacaftor/ivacaftor is a CFTR modulator approved to treat people with cystic fibrosis (pwCF) who are homozygous (F/F) or heterozygous for the F508del-CFTR mutation and a residual function mutation (F/RF). This randomized, double-blind, placebo-controlled Phase 3 study evaluated the efficacy, safety, tolerability, and pharmacokinetics (PK) of tezacaftor/ivacaftor in participants ≥12 years of age heterozygous for the F508del-CFTR mutation and a minimal function mutation (F/MF)...
#1Naomi E. Wijker (EUR: Erasmus University Rotterdam)H-Index: 1
#2Suzanna Vidmar (University of Melbourne)H-Index: 16
Last. Claire E. Wainwright (UQ: University of Queensland)H-Index: 41
view all 13 authors...
Introduction Little is known about early predictors of later cystic fibrosis (CF) structural lung disease. This study examined early predictors of progressive structural lung abnormalities in children who completed the Australasian CF Bronchoalveolar Lavage (ACFBAL) clinical trial at age 5-years and participated in an observational follow-up study (CF-FAB). Methods Eight Australian and New Zealand CF centres participated in CF-FAB and provided follow-up chest computed-tomography (CT) scans for c...
1 CitationsSource
#1Susannah Ahern (Monash University)H-Index: 5
#2Joanne Tracey Dean (Monash University)H-Index: 2
Last. Peter G. Middleton (USYD: University of Sydney)H-Index: 19
view all 14 authors...
Abstract Clinical registries that monitor and review outcomes for patients with cystic fibrosis have existed internationally for many decades. However, their purpose continues to evolve and now includes the capability to support clinical effectiveness research, clinical trials and Phase IV studies, and international data comparisons and projects. To achieve this, registries must regularly update the information that they collect and ensure design that is adaptable and flexible to changing needs....
#1Steven L. Taylor (Flinders University)H-Index: 10
#2Lex E.X. Leong (South Australia Pathology)H-Index: 1
Last. Geraint B. Rogers (Flinders University)H-Index: 36
view all 7 authors...
Abstract Background Cystic fibrosis (CF) is characterised by reduced airway clearance, microbial accumulation, inflammation, and lung function decline. Certain bacterial species may contribute disproportionately to worsening lung disease. However, the relative importance of these microorganisms compared to the absolute abundance of all bacteria is uncertain. We aimed to identify the characteristics of lower airway microbiology that best reflect CF airway inflammation and disease in children. Met...
#1Joyce Cheney (UQ: University of Queensland)H-Index: 9
#2Suzanna Vidmar (University of Melbourne)H-Index: 16
Last. Tonia Douglas (UQ: University of Queensland)H-Index: 4
view all 5 authors...
Abstract Background The impact of early cystic fibrosis (CF) on health-related quality-of-life (HRQOL) in preschool children is poorly characterised, and data on relationships between HRQOL and health outcomes in young children with CF are limited. We aimed to characterise and compare parent-proxy and child-reported HRQOL and evaluate relationships with clinical outcomes at age 5-years. Methods Subjects were participating in the multi-centre Australasian Cystic Fibrosis Bronchoalveolar Lavage (A...
#1Mona Al Langawi (Hamad Medical Corporation)H-Index: 1
#2Cass Byrnes (University of Auckland)H-Index: 5
Last. Elizabeth Tullis (St. Michael's Hospital)H-Index: 45
view all 11 authors...
Abstract The focus for International Women's Day 2020 is gender equity:'We can actively choose to challenge stereotypes, fight bias, broaden perceptions, improve situations and celebrate women's achievements. Collectively, each one of us can help create a gender equal world.' We have come together as an international group of women holding senior positions within CF to raise awareness. There is growing recognition of gender imbalance within our sector in senior leadership, grant and publication ...
2 CitationsSource
#1Patrick A. FlumeH-Index: 41
Last. Neil Ahluwalia (Vertex Pharmaceuticals)H-Index: 2
view all 12 authors...
#1James B. Geake (Royal Adelaide Hospital)H-Index: 6
#2Emma Ballard (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 10
Last. Scott C. Bell (UQ: University of Queensland)H-Index: 47
view all 6 authors...
Cystic fibrosis (CF) is a common life-limiting genetic condition. As the disease progresses access to specialist tertiary multi-disciplinary care services may become necessary. For patients living in regional/remote Australia, accessing such services may be a challenge. Here, we describe long-term outcomes for CF patients according to their access to specialist CF centre care in childhood.
#1Rebecca E Stockwell (UQ: University of Queensland)H-Index: 6
#2Michelle Wood (UQ: University of Queensland)H-Index: 8
Last. Scott C. Bell (UQ: University of Queensland)H-Index: 47
view all 6 authors...
The 2013 update of the Infection Prevention and Control (IPC 76% (41/54) had implemented segregation strategies for ambulatory care and no CF centers housed people with CF in shared inpatient accommodation. However, the application of contact precautions (wearing gloves and apron/gown) by healthcare professionals when reviewing a CF person was variable between CF center respondents but was most often used when seeing CF persons with MRSA infection in both ambulatory care and hospital admission (...
#1Claire E. Wainwright (Exponent)H-Index: 41
#2Rachel M. Mitchell (NAU: Northern Arizona University)H-Index: 8
Last. Jonathan D. Bakker (UW: University of Washington)H-Index: 34
view all 3 authors...
Long-term monitoring is an integral part of land management and biodiversity conservation. Sampling grain, a key component of monitoring design, can impact conclusions about spatial patterns in composition, but less is known about how sampling grain influences our ability to detect temporal compositional dynamics.To evaluate how sampling grain affects conclusions about temporal dynamics, we analyzed vegetation data from permanently marked transects in a sagebrush-steppe ecosystem. Each transect ...