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Valerio Leoni
University of Bologna
16Publications
8H-index
237Citations
Publications 16
Newest
#1Laura MenottiH-Index: 17
#2Valerio LeoniH-Index: 8
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#1Andrea VanniniH-Index: 7
#2Biljana PetrovicH-Index: 5
Last.Tatiana GianniH-Index: 15
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Source
#1Andrea Vannini (UNIBO: University of Bologna)H-Index: 7
#2Valerio Leoni (UNIBO: University of Bologna)H-Index: 8
Last.Tatiana Gianni (UNIBO: University of Bologna)H-Index: 15
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Tumors utilize a number of effective strategies, including the programmed death 1/PD ligand 1 (PD-1/PD-L1) axis, to evade immune-mediated control of their growth. PD-L1 expression is mainly induced by IFN receptor signaling or constitutively induced. Integrins are an abundantly expressed class of proteins which play multiple deleterious roles in cancer and exert proangiogenic and prosurvival activities. We asked whether αvβ3-integrin positively regulates PD-L1 expression and the anticancer immun...
2 CitationsSource
#1Valerio Leoni (UNIBO: University of Bologna)H-Index: 8
#2Andrea Vannini (UNIBO: University of Bologna)H-Index: 7
Last.Gabriella Campadelli-Fiume (UNIBO: University of Bologna)H-Index: 41
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Oncolytic herpes simplex viruses (oHSVs) showed efficacy in clinical trials and practice. Most of them gain cancer-specificity from deletions/mutations in genes that counteract the host response, and grow selectively in cancer cells defective in anti-viral response. Because of the deletions/mutations, they are frequently attenuated or over-attenuated. We developed next-generation oHSVs, which carry no deletion/mutation, gain cancer-specificity from specific retargeting to tumor cell receptors—e....
10 CitationsSource
3 CitationsSource
4 CitationsSource
#1Valerio Leoni (UNIBO: University of Bologna)H-Index: 8
#2Biljana Petrovic (UNIBO: University of Bologna)H-Index: 5
Last.Gabriella Campadelli-Fiume (UNIBO: University of Bologna)H-Index: 41
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1 CitationsSource
3 CitationsSource
#1Valerio Leoni (UNIBO: University of Bologna)H-Index: 8
#2Valentina Gatta (UNIBO: University of Bologna)H-Index: 4
Last.Gabriella Campadelli-Fiume (UNIBO: University of Bologna)H-Index: 41
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7 CitationsSource
#2Biljana PetrovicH-Index: 5
Last.Valentina GattaH-Index: 4
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Most of the oncolytic herpes simplex viruses (HSVs) exhibit a high safety profile achieved through attenuation. They carry defects in virulence proteins that antagonize host cell response to the virus, including innate response, apoptosis, authophagy, and depend on tumor cell proliferation. They grow robustly in cancer cells, provided that these are deficient in host cell responses, which is often the case. To overcome the attenuation limits, a strategy is to render the virus highly cancer-speci...
14 CitationsSource
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