Matthias Blüher
Leipzig University
EndocrinologyAdipose tissueInsulin resistanceDiabetes mellitusMedicine
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Publications 608
#1V. RichterH-Index: 13
#2Matthias BlüherH-Index: 79
Last. M. Hamm
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#2Michael Rullmann (Leipzig University)H-Index: 7
Last. Matthias Blüher (Leipzig University)H-Index: 79
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#1Stefan Kalkhof (Helmholtz Centre for Environmental Research - UFZ)H-Index: 20
#2Laura Krieg (Helmholtz Centre for Environmental Research - UFZ)
Last. Wieland KiessH-Index: 68
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Most information on molecular processes accompanying and driving adipocyte differentiation are derived from rodent models. Here, we provide a comprehensive analysis of combined transcriptomic and proteomic alterations during adipocyte differentiation in Simpson-Golabi-Behmel Syndrome (SGBS) cells. The SGBS cells are a well-established and the most widely applied cell model to study human adipocyte differentiation and cell biology. However, the molecular alterations during human adipocyte differe...
#1Robert HauffeH-Index: 1
Last. Johannes F. Kopp (University of Potsdam)H-Index: 1
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Insulin receptor signaling is crucial for white adipose tissue (WAT) function. Consequently, lack of insulin receptor (IR) in WAT results in a diabetes-like phenotype. Yet, causes for IR downregulation in WAT of diabetic patients are not well understood. By using multiple mouse models of obesity and insulin resistance, we identify a common downregulation of the IR with a reduction of mRNA expression of the selenoproteins Txnrd3, Sephs2, and Gpx3. Consistently, GPX3 is also decreased in adipose t...
#1Matthias Blüher (Leipzig University)H-Index: 79
Obesity contributes to reduced life expectancy, impaired quality of life and disabilities mainly in those individuals who develop cardiovascular diseases, type 2 diabetes, osteoarthritis and cancer. However, there is large variation in the individual risk to develop obesity-associated comorbid diseases which cannot simply be explained by the extent of adiposity. Observations that a proportion of individuals with obesity have a significantly lower risk for cardiometabolic abnormalities led to the...
#1Dominique Blaue (Leipzig University)
#2Carola Schedlbauer (Leipzig University)
Last. Ingrid Vervuert (Leipzig University)H-Index: 12
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BACKGROUND: Human obesity is linked with systemic inflammation. However, it is still controversial if equines produce more inflammatory cytokines with increasing body weight and if the production of those show breed type specific patterns. The main objective of this study was to determine if diet induced obesity is associated with increased inflammatory signatures in adipose tissue of equines and if a breed predisposition exists between ponies and horses. Additionally, we aimed to identify adipo...
#1Lucas Massier (Leipzig University)
#2Rima Chakaroun (Leipzig University)H-Index: 4
Last. Michael Stumvoll (Leipzig University)H-Index: 92
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OBJECTIVE: Bacterial translocation to various organs including human adipose tissue (AT) due to increased intestinal permeability remains poorly understood. We hypothesised that: (1) bacterial presence is highly tissue specific and (2) related in composition and quantity to immune inflammatory and metabolic burden. DESIGN: We quantified and sequenced the bacterial 16S rRNA gene in blood and AT samples (omental, mesenteric and subcutaneous) of 75 subjects with obesity with or without type 2 diabe...
#1Y MoullaH-Index: 2
#2Orestis LyrosH-Index: 8
Last. Boris Jansen-WinkelnH-Index: 5
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In the original article the name of author Matthias Bluher was incorrect. It is correct here and the original article has been corrected.
1 CitationsSource
#1Thomas Ebert (KI: Karolinska Institutet)H-Index: 17
#2Claudia Gebhardt (Leipzig University)H-Index: 4
Last. Anke Tönjes (Leipzig University)H-Index: 56
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Abstract Aims Adipose tissue-secreted proteins, i.e. adipocytokines, have been identified as potential mediators linking fat mass and adipose tissue dysfunction with impaired glucose homeostasis, alterations in the inflammatory status, and risk of diabetes. The aim of this study was to determine whether seven circulating adipocytokines are associated with gestational diabetes mellitus (GDM) or are altered by metabolic and weight changes during pregnancy itself. Methods A panel of seven adipocyto...
#1Petra Baum (Leipzig University)H-Index: 11
#2Sabine Paeschke (Leipzig University)H-Index: 3
Last. Joanna Kosacka (Leipzig University)H-Index: 14
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Cartilage oligomeric matrix protein (COMP)-Angiopoietin-1 is a potent angiopoietin-1 (Ang-1) variant that possesses therapeutic potential in angiogenesis and vascular endothelial dysfunction. Noteworthy, we have shown that COMP-Ang-1 improves hyperglycemia and neuroregeneration in ob/ob mice. However, the mechanism of the antidiabetic effect of COMP-Ang-1 is completely unknown. Therefore, we elucidated the diabetes protective molecular mechanisms of COMP-Ang-1 in diabetic db/db mouse model. COMP...