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Leonardo Nazario de Moraes
Sao Paulo State University
19Publications
6H-index
144Citations
Publications 19
Newest
#1Leonardo Nazario de Moraes (UNESP: Sao Paulo State University)H-Index: 6
#2Rejane Maria Tommasini Grotto (UNESP: Sao Paulo State University)H-Index: 6
Last.Rafael Plana Simões (UNESP: Sao Paulo State University)H-Index: 4
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Abstract NS3 is an important therapeutic target for direct-acting antiviral (DAA) drugs. However, many patients treated with DAAs have unsustained virologic response (UVR) due to the high mutation rate of HCV. The aim of this work was to shed some light on the puzzling molecular mechanisms of the virus’s of patients who showed high viral loads even under treatment with DAA. Bioinformatics tools, molecular modelling analyses were employed to identify mutations associated with HCV resistance to bo...
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#2J H FerreiraH-Index: 2
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#1Lauana Fogaça de Almeida (UNESP: Sao Paulo State University)H-Index: 1
#2Leonardo Nazario de Moraes (UNESP: Sao Paulo State University)H-Index: 6
Last.Guilherme Targino Valente (UNESP: Sao Paulo State University)H-Index: 13
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Abstract Mass spectrometry is the most used method for protein identification and quantification. Here we developed four protein extraction protocols precisely for mass spectrometry, and we compared with other ones already published. The best protocol developed by us consists on a simple extraction solution, a heat-shock step, and does not use protease inhibitor; moreover, it is the most efficient and uniform among replicates, besides to be safe, cheap and fast. That method also provided the hig...
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#1Mariana Antunes Ribeiro (UNESP: Sao Paulo State University)H-Index: 4
#2Molly Estill (WSU: Wayne State University)H-Index: 3
Last.Wellerson R. Scarano (UNESP: Sao Paulo State University)H-Index: 14
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Abstract Male fertility and spermatogenesis are directly linked to the Sertoli cell’s ability to produce factors associated with germ cell development. Sertoli cells express receptors for FSH and testosterone, and are the major regulators of spermatogenesis. Recent studies report that regulatory RNA molecules, such as microRNAs (miRNAs), are able to modulate testicular function during spermatogenesis and that their altered expression may be involved in male infertility. miRNAs may play a role in...
3 CitationsSource
#1J H Ferreira (UNESP: Sao Paulo State University)H-Index: 2
#2Sarah Santiloni Cury (UNESP: Sao Paulo State University)H-Index: 2
Last.Robson Francisco Carvalho (UNESP: Sao Paulo State University)H-Index: 19
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Low-level laser irradiation (LLLI) has been used as a non-invasive method to improve muscular regeneration capability. However, the molecular mechanisms by which LLLI exerts these effects remain largely unknown. Here, we described global gene expression profiling analysis in C2C12 myoblasts after LLLI that identified 514 differentially expressed genes (DEG). Gene ontology and pathway analysis of the DEG revealed transcripts among categories related to cell cycle, ribosome biogenesis, response to...
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#1Nelci A. de Moura (UNESP: Sao Paulo State University)H-Index: 4
#2Brunno F.R. Caetano (UNESP: Sao Paulo State University)H-Index: 3
Last.Luis Fernando Barbisan (UNESP: Sao Paulo State University)H-Index: 22
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Abstract The risk of developing colorectal cancer (CRC) could be associated with red and processed meat intake. Experimental data supports that hemin iron, found abundantly in red meat, promotes CRC in mice and rats, while indole-3 carbinol (I3C) and synbiotics (syn) exert anti-carcinogenic activities in most studies of colon carcinogenesis. This study aimed to investigate the modifying effects of I3C and syn (inulin + Bifidobacterium lactis ), given separately or together, on dimethylhidrazine ...
1 CitationsSource
Background: Aortic regurgitation (AR) is a valvulopathy that causes volume overload to the heart leading to left ventricle dilation and eccentric hypertrophy. A common co-morbidity associated with cardiovascular disease is depression. We have previously shown that paroxetine, a selective serotonin re-uptake inhibitor widely prescribed as antidepressant, improves cardiac contractility by preserving fractional shortening (FS) of AR rat hearts. In failing hearts, decrease of the ability of the myoc...
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#1Leonardo Nazario de Moraes (UNESP: Sao Paulo State University)H-Index: 6
#2Geysson Javier Fernandez (UNESP: Sao Paulo State University)H-Index: 5
Last.Robson Francisco Carvalho (UNESP: Sao Paulo State University)H-Index: 19
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Cardiac cachexia (CC) is a common complication of heart failure (HF) associated with muscle wasting and poor patient prognosis. Although different mechanisms have been proposed to explain muscle wasting during CC, its pathogenesis is still not understood. Here, we described an integrative analysis between miRNA and mRNA expression profiles of muscle wasting during CC. Global gene expression profiling identified 1,281 genes and 19 miRNAs differentially expressed in muscle wasting during CC. Sever...
5 CitationsSource
#1Paula Paccielli Freire (UNESP: Sao Paulo State University)H-Index: 4
#2Sarah Santiloni Cury (UNESP: Sao Paulo State University)H-Index: 2
Last.Robson Francisco Carvalho (UNESP: Sao Paulo State University)H-Index: 19
view all 11 authors...
Skeletal myogenesis is a regulated process in which mononucleated cells, the myoblasts, undergo proliferation and differentiation. Upon differentiation, the cells align with each other, and subsequently fuse to form terminally differentiated multinucleated myotubes. Previous reports have identified the protein osteoglycin (Ogn) as an important component of the skeletal muscle secretome, which is expressed differentially during muscle development. However, the posttranscriptional regulation of Og...
12 CitationsSource
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