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Yutaka Seino
Kyoto University
EndocrinologyType 2 diabetesInsulinDiabetes mellitusMedicine
544Publications
58H-index
14.8kCitations
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#1Bo Ahrén (Lund University)H-Index: 88
#2Yuchiro Yamada (Akita University)H-Index: 2
Last. Yutaka SeinoH-Index: 58
view all 3 authors...
Abstract Glucose-dependent insulinotropic polypeptide (GIP) receptor knockout (KO) mice are tools for studying GIP physiology. Previous results have demonstrated that these mice have impaired insulin response to oral glucose. In this study, we examined the insulin response to intravenous glucose by measuring glucose, insulin and C-peptide after intravenous glucose (0.35 g/kg) in 5-h fasted female GIP receptor KO mice and their wild-type (WT) littermates. The 1 min insulin and C-peptide responses...
1 CitationsSource
#1Bo Ahrén (Lund University)H-Index: 88
#2Yuichiro Yamada (Akita University)H-Index: 34
Last. Yutaka SeinoH-Index: 58
view all 3 authors...
To establish the contribution of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) for the incretin effect after oral glucose, studies were undertaken in female mice with genetic deletion of receptors for GIP and GLP-1 (double incretin receptor knockout [DIRKO] mice) and their wild-type (WT) counterparts. Insulin secretion was explored after oral glucose (doses ranging from 0 to 100 mg), after intravenous glucose (doses ranging from 0 to 0.75 g/kg), and after...
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#1Mark E. Cooper (Monash University)H-Index: 128
#2Julio Rosenstock (UTSW: University of Texas Southwestern Medical Center)H-Index: 113
Last. Odd Erik Johansen (Boehringer Ingelheim)H-Index: 26
view all 8 authors...
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#1Daisuke YabeH-Index: 31
#2Hitoshi KuwataH-Index: 10
Last. Yutaka SeinoH-Index: 58
view all 16 authors...
Abstract Background Although lifestyle modifications are known to be effective in type 2 diabetes (T2D) as well as in prediabetes, adherence to a healthy diet is difficult for some, and interventions of lifestyle modifications need to be revised occasionally. Meal sequence has been gaining attention as a part of a healthy diet among T2D individuals to improve glycemia and body weight. In addition, a dietary instruction program, SMART Washoku®, which can help individuals to consume a more nutriti...
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#1Daisuke Yabe (Gidai: Gifu University)H-Index: 31
#2Hitoshi KuwataH-Index: 10
Last. Yutaka SeinoH-Index: 58
view all 3 authors...
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#1Ryota Usui (Kyoto University)H-Index: 6
#2Daisuke YabeH-Index: 31
Last. Yutaka SeinoH-Index: 58
view all 3 authors...
2 CitationsSource
#1Manabu Hoizumi (Akita University)
#2Takehiro Sato (Akita University)H-Index: 7
Last. Yuichiro Yamada (Akita University)H-Index: 34
view all 11 authors...
Abstract Aims/introduction Caloric restriction (CR) promotes longevity and exerts anti-aging effects by increasing Sirtuin production and activation. Gastric inhibitory polypeptide (GIP), a gastrointestinal peptide hormone, exerts various effects on pancreatic β-cells and extra-pancreatic tissues. GIP promotes glucose-dependent augmentation of insulin secretion and uptake of nutrients into the adipose tissue. Materials and methods Gipr-/- and Gipr+/+ mice were used for lifespan analysis, behavio...
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#1Yoichi OikawaH-Index: 14
Last. Masafumi KitaokaH-Index: 4
view all 5 authors...
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#1Hitoshi KuwataH-Index: 10
#2Daisuke YabeH-Index: 31
Last. Yutaka SeinoH-Index: 58
view all 5 authors...
Background: It has been suggested that short- and long-acting glucagon-like peptide 1 receptor agonists (GLP-1RAs) exert different actions on gastric emptying rate (GE). However, the alterations in gastric emptying and their contributions to postprandial glucose and lipid excursions have not been fully evaluated. Methods: A 3-arm non-randomized trial was conducted in Japanese patients with type 2 diabetes. Meal tolerance test was performed before and 12 weeks after initiation of treatment by sho...
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#2Hitoshi KuwataH-Index: 10
Last. Yutaka SeinoH-Index: 58
view all 7 authors...
Aim: The objective of this study is to investigate the relationship between meal habits and skeletal muscle mass (SMM) in elderly Japanese type 2 diabetes (T2D) patients. Subjects and Methods: This is a retrospective study of the medical records of 68 elderly(≧65 years old) T2D patients who were admitted to hospital for diabetes conditions and received dietary instructions from January 2014 to September 2017. Upon release, we ascertained nutrition intake by self-administered 3-day food records c...
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