Siu Ling Wong
Harvard University
EndocrinologyNeutrophil extracellular trapsAngiotensin IIMedicineBiology
What is this?
Publications 34
#1Siu Ling Wong (Harvard University)H-Index: 18
#2Jeremy Goverman (Shriners Hospitals for Children)H-Index: 19
Last. Denisa D. Wagner (Harvard University)H-Index: 105
view all 4 authors...
Enhancing skin allograft longevity lessens the need for new allografts before optimal intervention is available. Reduced activity of ADAMTS13 (an enzyme that cleaves the pro-thrombotic and proinflammatory von Willebrand factor) and presence of neutrophil extracellular traps (NETs) have been implicated in liver and lung allograft failures. The effect of ADAMTS13 treatment and the impact of NETs on skin allografts, however, remain unexplored. Here, we adopted a murine model of complete mismatch fu...
#1Hawa Racine Thiam (NIH: National Institutes of Health)H-Index: 1
#2Siu Ling Wong (Harvard University)H-Index: 18
Last. Clare M. Waterman (NIH: National Institutes of Health)H-Index: 35
view all 9 authors...
Neutrophil extracellular traps (NETs) are web-like DNA structures decorated with histones and cytotoxic proteins that are released by activated neutrophils to trap and neutralize pathogens during the innate immune response, but also form in and exacerbate sterile inflammation. Peptidylarginine deiminase 4 (PAD4) citrullinates histones and is required for NET formation (NETosis) in mouse neutrophils. While the in vivo impact of NETs is accumulating, the cellular events driving NETosis and the rol...
1 CitationsSource
#1Siu Ling Wong (Harvard University)H-Index: 18
#2Denisa D. Wagner (Harvard University)H-Index: 105
Peptidylarginine deiminase 4 (PAD4) is a nuclear citrullinating enzyme that is critically involved in the release of decondensed chromatin from neutrophils as neutrophil extracellular traps (NETs)....
3 CitationsSource
#1Hideki HayashiH-Index: 21
#2Deya CherpokovaH-Index: 10
Last. Denisa D. WagnerH-Index: 105
view all 9 authors...
: Inflammation is a common denominator in chronic diseases of aging. Yet, how inflammation fuels these diseases remains unknown. Neutrophils are the primary leukocytes involved in the early phase of innate immunity and inflammation. As part of their anti-microbial defense, neutrophils form extracellular traps (NETs) by releasing decondensed chromatin lined with cytotoxic proteins. NETs have been shown to induce tissue injury and thrombosis. Here, we demonstrated that Sirt3, a nicotinamide adenin...
5 CitationsSource
#1Melanie Demers (Boston Children's Hospital)H-Index: 20
#2Siu Ling Wong (Boston Children's Hospital)H-Index: 18
Last. Denisa D. Wagner (Boston Children's Hospital)H-Index: 105
view all 7 authors...
ABSTRACTNeutrophils play a major role in cancer biology and both pro- and antitumoral functions of tumor-infiltrating neutrophils have been described. We have shown that tumors, by releasing G-CSF into the bloodstream, prime circulating neutrophils to form neutrophil extracellular traps (NETs) and we have detected the presence of NETs within the tumor microenvironment. Here, we report, using PAD4-deficient mice with a defect in neutrophil chromatin decondensation and NET formation, that the prim...
43 CitationsSource
#1Charlotte Thålin (KI: Karolinska Institutet)H-Index: 7
#2Melanie Demers (Harvard University)H-Index: 20
Last. Sara Aspberg (KI: Karolinska Institutet)H-Index: 9
view all 10 authors...
Abstract Introduction Large elevations of high sensitive Troponin T (hsTnT) in ischemic stroke patients is associated with a poor outcome. In a pilot study we found a high prevalence of malignancies among these patients. Since neutrophil extracellular traps (NETs) have been linked to cancer-associated thrombosis, we hypothesized that the concomitant cerebral and myocardial ischemia could be the result of a NET-induced hypercoagulable state. Materials and methods Clinical assessments, plasma anal...
46 CitationsSource
#1Julia Etulain (CONICET: National Scientific and Technical Research Council)H-Index: 1
#2Kimberly Martinod (Harvard University)H-Index: 22
Last. Denisa D. Wagner (Boston Children's Hospital)H-Index: 105
view all 6 authors...
Neutrophil extracellular traps (NETs) can be released in the vasculature. In addition to trapping microbes, they promote inflammatory and thrombotic diseases. Considering that P-selectin induces prothrombotic and proinflammatory signaling, we studied the role of this selectin in NET formation. NET formation (NETosis) was induced by thrombin-activated platelets rosetting with neutrophils and was inhibited by anti-P-selectin aptamer or anti-P-selectin glycoprotein ligand-1 (PSGL-1) inhibitory anti...
116 CitationsSource
#1Siu Ling WongH-Index: 18
#2Melanie DemersH-Index: 20
Last. Denisa D. WagnerH-Index: 105
view all 8 authors...
Neutraphil extracellular trap formation is increased in type 1 and 2 diabetes and impairs wound healing.
248 CitationsSource
#1Kimberly Martinod (Harvard University)H-Index: 22
#2Tobias A. Fuchs (Harvard University)H-Index: 27
Last. Denisa D. Wagner (Harvard University)H-Index: 105
view all 8 authors...
Neutrophil extracellular traps (NETs), consisting of nuclear DNA with histones and microbicidal proteins, are expelled from activated neutrophils during sepsis. NETs were shown to trap microbes, but they also fuel cardiovascular, thrombotic, and autoimmune disease. The role of NETs in sepsis, particularly the balance between their antimicrobial and cytotoxic actions, remains unclear. Neutrophils from peptidylarginine deiminase 4-(PAD4−/−) deficient mice, which lack the enzyme allowing for chroma...
84 CitationsSource
#1Xiaojia Ni (Guangzhou University of Chinese Medicine)H-Index: 6
#2Siu Ling Wong (CUHK: The Chinese University of Hong Kong)H-Index: 18
Last. YuHUANG (CUHK: The Chinese University of Hong Kong)H-Index: 70
view all 7 authors...
Background and Objectives. Oxidative stress can initiate endothelial dysfunction and atherosclerosis. This study evaluated whether tetramethylpyrazine (TMP), the predominant active ingredient in Rhizoma Ligustici Wallichii (chuanxiong), prevents endothelial dysfunction in a rat model of oxidative stress. Methods. Isolated rat aortic rings were pretreated with various drugs before the induction of endothelial dysfunction by hydrogen peroxide (H2O2). Changes in isometric tension were then measured...
4 CitationsSource