Saira Saeed Mirza
Erasmus University Rotterdam
PsychiatryRotterdam StudyDementiaPopulationMedicine
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Publications 62
#1Azmeraw T. Amare (University of Adelaide)H-Index: 40
#3Klaus Oliver Schubert (University of Adelaide)H-Index: 9
Last. Fasil Tekola-Ayele (NIH: National Institutes of Health)H-Index: 13
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Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for major depression (MD) at different GWAS p value thresholds using genetic data obtain...
Objective To determine if APOE e4 influences the association between white matter hyperintensities (WMH) and cognitive impairment in Alzheimer disease (AD) and dementia with Lewy bodies (DLB). Methods A total of 289 patients (AD = 239; DLB = 50) underwent volumetric MRI, neuropsychological testing, and APOE e4 genotyping. Total WMH volumes were quantified. Neuropsychological test scores were included in a confirmatory factor analysis to identify cognitive domains encompassing attention/executive...
#2Joel RamirezH-Index: 15
Last. Sandra E. BlackH-Index: 89
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#1Darina Czamara (MPG: Max Planck Society)H-Index: 5
#2Gökcen Eraslan (TUM: Technische Universität München)H-Index: 4
Last. Elisabeth B. Binder (MPG: Max Planck Society)H-Index: 75
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Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overal...
2 CitationsSource
#2Saira Saeed MirzaH-Index: 14
Last. Mario MasellisH-Index: 27
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In the original version of this article, the affiliation details for Sandro Sorbi were incomplete; this has now been corrected. The authors apologise for this mistake.
#1Darina CzamaraH-Index: 5
Last. Rebecca M. ReynoldsH-Index: 65
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#1Miruna C. Barbu (Edin.: University of Edinburgh)H-Index: 5
#2Thalia C. Eley (Medical Research Council)H-Index: 56
Last. Jorge A. Quiroz (Edin.: University of Edinburgh)H-Index: 23
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Background: Major depressive disorder is a clinically heterogeneous psychiatric disorder with a polygenic architecture. Genome-wide association studies have identified a number of risk-associated variants across the genome and have reported growing evidence of NETRIN1 pathway involvement. Stratifying disease risk by genetic variation within the NETRIN1 pathway may provide important routes for identification of disease mechanisms by focusing on a specific process, excluding heterogeneous risk-ass...
3 CitationsSource
#1Simone de Jong (Centre for Mental Health)H-Index: 16
#2Mateus Jose Abdalla Diniz (UNIFESP: Federal University of São Paulo)H-Index: 2
Last. Julia ShiH-Index: 52
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Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patter...
2 CitationsSource
#1Usman Saeed (U of T: University of Toronto)H-Index: 4
#2Saira Saeed Mirza (U of T: University of Toronto)H-Index: 14
Last. Mario MasellisH-Index: 27
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Abstract Introduction Although the apolipoprotein E e4-allele (APOE-e4) is a susceptibility factor for Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), its relationship with imaging and cognitive measures across the AD/DLB spectrum remains unexplored. Methods We studied 298 patients (AD = 250, DLB = 48; 38 autopsy-confirmed; NCT01800214 ) using neuropsychological testing, volumetric magnetic resonance imaging, and APOE genotyping to investigate the association of APOE-e4 with hippoc...
5 CitationsSource
#1Saira Saeed MirzaH-Index: 14
#2Usman SaeedH-Index: 4
Last. Mario MasellisH-Index: 27
view all 6 authors...