Saira Saeed Mirza
Erasmus University Rotterdam
Publications 60
#1Darina Czamara (MPG: Max Planck Society)H-Index: 26
#2Gökcen Eraslan (TUM: Technische Universität München)H-Index: 2
Last.Rebecca M. Reynolds (BHF: British Heart Foundation)H-Index: 62
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Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overal...
#1Jakob GroveH-Index: 33
#2Stephan RipkeH-Index: 66
Last.Richard Anney (Cardiff University)H-Index: 43
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Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genom...
#1Miruna C. Barbu (Edin.: University of Edinburgh)H-Index: 4
#2Thalia C. Eley (Medical Research Council)H-Index: 54
Last.Martin PreisigH-Index: 47
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Abstract Background Major depressive disorder is a clinically heterogeneous psychiatric disorder with a polygenic architecture. Genome-wide association studies have identified a number of risk-associated variants across the genome and have reported growing evidence of NETRIN1 pathway involvement. Stratifying disease risk by genetic variation within the NETRIN1 pathway may provide important routes for identification of disease mechanisms by focusing on a specific process, excluding heterogeneous ...
#1Usman Saeed (U of T: University of Toronto)H-Index: 4
#2Saira Saeed Mirza (U of T: University of Toronto)H-Index: 14
Last.Walter SwardfagerH-Index: 23
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Abstract Introduction Although the apolipoprotein E e4-allele ( APOE -e4) is a susceptibility factor for Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), its relationship with imaging and cognitive measures across the AD/DLB spectrum remains unexplored. Methods We studied 298 patients (AD = 250, DLB = 48; 38 autopsy-confirmed; NCT01800214) using neuropsychological testing, volumetric magnetic resonance imaging, and APOE genotyping to investigate the association of APOE -e4 with hipp...
#1Naomi R. Wray (UQ: University of Queensland)H-Index: 72
#2Stephan Ripke (Charité)H-Index: 66
Last.Till M. F. Andlauer (MPG: Max Planck Society)H-Index: 1
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Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved ...