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Kasthuri Bai Magalingam
Nilai University
RutinOxidative stressGlutathione peroxidaseLipid peroxidationQuercetin
6Publications
6H-index
209Citations
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Publications 6
Newest
#1Kasthuri Bai Magalingam (Nilai University)H-Index: 6
#2Ammu Kutty Radhakrishnan (International Medical University)H-Index: 23
Last. Nagaraja Haleagrahara (JCU: James Cook University)H-Index: 18
view all 4 authors...
Neurodegenerative diseases are hereditary or sporadic conditions that result in the progressive loss of the structure and function of neurons as well as neuronal death. Although a range of diseases lie under this umbrella term, Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative diseases that affect a large population around the globe. Alzheimer’s disease is characterized by the abnormal accumulation of extracellular amyloid-β plaques and intraneuronal neu...
15 CitationsSource
#1Kasthuri Bai Magalingam (Nilai University)H-Index: 6
#2Ammu Radhakrishnan (Nilai University)H-Index: 1
Last. Nagaraja Haleagrahara (JCU: James Cook University)H-Index: 18
view all 3 authors...
There is increasing evidence that free radicals induced oxidative stress is a major causative agent in the pathogenesis of neurodegenerative diseases, particularly Parkinson's disease. Quercetin glycosides, namely rutin and isoquercitrin, are flavonoid polyphenol compounds found ubiquitously in fruits and vegetables and have been known to possess antioxidant effects. This study was designed to compare the neuroprotective effects of quercetin glycosides rutin and isoquercitrin in 6-OHDA-induced r...
19 CitationsSource
#1Kasthuri Bai Magalingam (International Medical University)H-Index: 6
#2Ammu Kutty Radhakrishnan (International Medical University)H-Index: 23
Last. Nagaraja Haleagrahara (JCU: James Cook University)H-Index: 18
view all 3 authors...
Parkinson's disease is a chronic, debilitating neurodegenerative movement disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta region in human midbrain. To date, oxidative stress is the well accepted concept in the etiology and progression of Parkinson's disease. Hence, the therapeutic agent is targeted against suppressing and alleviating the oxidative stress-induced cellular damage. Within the past decades, an explosion of research dis...
42 CitationsSource
#1Kasthuri Bai Magalingam (International Medical University)H-Index: 6
#2Ammu Kutty Radhakrishnan (International Medical University)H-Index: 23
Last. Nagaraja Haleagrahara (JCU: James Cook University)H-Index: 18
view all 4 authors...
Quercetin glycosides, rutin and isoquercitrin, are potent antioxidants that have been found to possess neuroprotective effect in diseases like Parkinson’s and Alzheimer’s disease. In the present study, we have examined the gene expression changes with rutin and isoquercitrin pretreatment on 6-hydroxydopamine (6-OHDA)-treated toxicity in rat pheochromocytoma (PC12) cells. PC12 cells were pretreated with rutin or isoquercitrin and subsequently exposed to 6-OHDA. Rutin-pretreated PC12 attenuated th...
21 CitationsSource
#1Kasthuri Bai Magalingam (International Medical University)H-Index: 6
#2Ammu Kutty Radhakrishnan (International Medical University)H-Index: 23
Last. Nagaraja Haleagrahara (JCU: James Cook University)H-Index: 18
view all 3 authors...
Free radicals-induced neurodegeneration is one of the many causes of Parkinson’s disease (PD). This study investigated the neuroprotective effects of flavonol isoquercitrin against toxicity induced by 6-hydroxy-dopamine (6-OHDA) in rat pheochromocytoma (PC12) cells. PC12 cells were pretreated with different concentrations of isoquercitrin for 4, 8 and 12 hours and incubated with 6-OHDA for 24 hours to induce oxidative cell damage. A significant cytoprotective activity was observed in isoquercitr...
36 CitationsSource
#1Kasthuri Bai Magalingam (International Medical University)H-Index: 6
#2Ammu Kutty Radhakrishnan (International Medical University)H-Index: 23
Last. Nagaraja Haleagrahara (JCU: James Cook University)H-Index: 18
view all 3 authors...
Free radicals are widely known to be the major cause of human diseases such as neurodegenerative diseases, cancer, allergy and autoimmune diseases. Human cells are equipped with a powerful natural antioxidant enzyme network. However, antioxidants, particularly those originating from natural sources such as fruits and vegetables, are still considered essential. Rutin, a quercetin glycoside, has been proven to possess antioxidant potential. However, the neuroprotective effect of rutin in pheochrom...
37 CitationsSource
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