Wenjie Deng
Nanjing Medical University
9Publications
5H-index
68Citations
Publications 9
Newest
Published on Sep 1, 2018in Cell Death and Disease 5.64
Shixiu Sun4
Estimated H-index: 4
(Nanjing Medical University),
Yujie Zhang9
Estimated H-index: 9
(Nanjing Medical University)
+ 9 AuthorsYongchang Chen4
Estimated H-index: 4
(Jiangsu University)
NVP-BEZ235 (BEZ235), an available dual PI3K/mTOR inhibitor, showed antitumor effect and provided a therapy strategy in carcinomas. However, the acquired upregulation of multiple receptor tyrosine kinases (RTKs) by NVP-BEZ235 in tumors limits its clinical efficacy. HDAC6, a class II histone deacetylase, is associated with expressions of multiple RTKs. The aim of this study was to detect whether co-treatment with HDAC6 inhibitor Tubastatin A (TST) would enhance the anticancer effects of BEZ235 in ...
Source Cite
Published on Jun 1, 2018in Journal of Cellular and Molecular Medicine 4.30
Wenjie Deng5
Estimated H-index: 5
(Nanjing Medical University),
Yueyuan Wang3
Estimated H-index: 3
(Nanjing Medical University)
+ 8 AuthorsBixing Ye2
Estimated H-index: 2
(Nanjing Medical University)
6 Citations Source Cite
Published on Nov 22, 2018in Frontiers in Pharmacology 3.83
Bixing Ye2
Estimated H-index: 2
(Nanjing Medical University),
Biao Duan4
Estimated H-index: 4
(Nanjing Medical University)
+ 9 AuthorsLuo Gu13
Estimated H-index: 13
(Nanjing Medical University)
Aims: The aim of this study was to reveal the specific molecular mechanisms by which DENND1A accepts EGF signaling and activates Rab35 in gastric cancer. Methods: The expression of proteins related to DENND1A was examined by western blot analysis. Activation of Rab35 was assessed by GST-pulldown. The interaction of DENND1A and Grb2 was assessed by GST-pulldown and coimmunoprecipitation assays. The relationship between DENND1A and cell migration and invasion was detected using wound healing and t...
Source Cite
Published on Feb 1, 2018in Acta Physiologica 5.93
Yueyuan Wang3
Estimated H-index: 3
(Nanjing Medical University),
Wenjie Deng5
Estimated H-index: 5
(Nanjing Medical University)
+ 6 AuthorsJun Du12
Estimated H-index: 12
(Nanjing Medical University)
Aim MICAL2, a cytoskeleton dynamics regulator, is identified associated with survival and metastasis of several types of cancers recently. The present study was designed to investigate the role of MICAL2 in breast cancer cell migration as well as its underlying mechanisms. Methods The relationship between MICAL2 and EGF/EGFR signaling was analyzed by using gene overexpression and knockdown techniques. Cell migration was measured by wound healing assays. Activation of EGF/EGFR singaling pathways ...
1 Citations Source Cite
Published on Oct 1, 2016in Tumor Biology
Jie Cui5
Estimated H-index: 5
(Nanjing Medical University),
Biao Duan4
Estimated H-index: 4
(Nanjing Medical University)
+ 7 AuthorsLuo Gu13
Estimated H-index: 13
(Nanjing Medical University)
Hypoxia-inducible factor 2α (HIF2α) plays critical roles in cancer progression. Although the mechanisms of HIF2α translation and degradation have been well studied, the mechanism for HIF2α regulation at transcriptional level is still not fully understood. Here, we present evidence that DNA methylation in promoter contributes to transcription of EPAS1 coding HIF2α. Methylated CpG binding protein 3 (MBD3) contributes to the intricate regulatory mechanism. We showed that MBD3 bound to the EPAS1 pro...
4 Citations Source Cite
Published on Aug 1, 2016in Cancer Letters 6.49
Biao Duan4
Estimated H-index: 4
(Nanjing Medical University),
Jie Cui5
Estimated H-index: 5
(Nanjing Medical University)
+ 9 AuthorsYichao Zhu11
Estimated H-index: 11
(Nanjing Medical University)
Abstract Non-small cell lung cancer (NSCLC) remains one of the most metastasizing tumors, and directional cell migration is critical for targeting tumor metastasis. GIT2 has been known to bind to Paxillin to control cell polarization and directional migration. However, the molecular mechanisms underlying roles of GIT2 in controlling cell polarization and directional migration remain elusive. Here we demonstrated GIT2 control cell polarization and direction dependent on the regulation of Golgi th...
11 Citations Source Cite
Published on Dec 1, 2016in Cancer Cell International 3.96
Wenjie Deng5
Estimated H-index: 5
(Nanjing Medical University),
Yujie Zhang9
Estimated H-index: 9
(Nanjing Medical University)
+ 4 AuthorsJun Du12
Estimated H-index: 12
(Nanjing Medical University)
Background Despite the fact that melatonin treatment shows some promise in gastric cancer, the molecular mechanisms of gastric cancer cells in response to melatonin remains to be determined.
15 Citations Source Cite
Published on Dec 1, 2016in BMC Cancer 3.29
Wenjie Deng5
Estimated H-index: 5
(Nanjing Medical University),
Yueyuan Wang3
Estimated H-index: 3
(Nanjing Medical University)
+ 7 AuthorsJun Du12
Estimated H-index: 12
(Nanjing Medical University)
Background Molecules Interacting with CasL (MICAL1), a multidomain flavoprotein monoxygenase, is strongly involved in the mechanisms that promote cancer cell proliferation and survival. Activation of MICAL1 causes an up-regulation of reactive oxygen species (ROS) in HeLa cells. ROS can function as a signaling molecule that modulates protein phosphorylation, leading to malignant phenotypes of cancer cells such as invasion and metastasis. Herein, we tested whether MICAL1 could control cell migrati...
16 Citations Source Cite
Published on Dec 1, 2016in Journal of Translational Medicine 4.20
Wenjie Deng5
Estimated H-index: 5
(Nanjing Medical University),
Luo Gu13
Estimated H-index: 13
(Nanjing Medical University)
+ 6 AuthorsJun Du12
Estimated H-index: 12
(Nanjing Medical University)
Background CD24, a mucin-like membrane glycoprotein, plays a critical role in carcinogenesis, but its role in human gastric cancer and the underlying mechanism remains undefined.
15 Citations Source Cite
1