Natalia Olaya
University of Paris-Sud
Publications 4
#1Chengyuan Peng (French Institute of Health and Medical Research)H-Index: 3
#2Slávka Kaščáková (French Institute of Health and Medical Research)H-Index: 5
Last.François Le Naour (French Institute of Health and Medical Research)H-Index: 28
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Background Hepatocarcinogenesis is a multistep process characterized in patients with chronic liver diseases by a spectrum of hepatic nodules that mark the progression from regenerative nodules to dysplastic lesions followed by hepatocellular carcinoma (HCC). The differential diagnosis between precancerous dysplastic nodules and early HCC still represents a challenge for both radiologists and pathologists. We addressed the potential of Fourier transform-infrared (FTIR) microspectroscopy for grad...
#1Natalia OlayaH-Index: 3
#2Franck ChiappiniH-Index: 10
Hepatocellular carcinoma (HCC) is responsible for significant morbidity and mortality in cirrhosis and also accounts for between 85% and 90% of primary liver cancer (Caldwell & Park 2009; Hussain & El-Serag 2009; Tandon & Garcia-Tsao 2009). Most of HCC in the world occur in the setting of cirrhosis and over half-million of people develop liver cancer every year and an almost equal number die of it (Caldwell & Park 2009; Hussain & El-Serag 2009). Liver cancer prognosis is determined by factors re...
#1Marie-Charlotte Domart (University of Paris-Sud)H-Index: 4
#2Davide Degli Esposti (University of Paris-Sud)H-Index: 18
Last.Antoinette Lemoine (University of Paris-Sud)H-Index: 38
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Background/Aims Liver pathology induced by chemotherapy (steatosis or vascular injury) is known to increase the liver's sensitivity to ischemia/ reperfusion (I/R) injury, thereby increasing morbidity and mortality after liver resection. Our aim was to assess whether ischemic preconditioning (IP) reduces I/R injury to livers with chemotherapy-induced pathology. Methods We analyzed a series of livers from patients treated with chemotherapy for colorectal cancer who underwent IP ( n =30) or not ( n...
#1Alain Barrier (University of California, Berkeley)H-Index: 15
#2Natalia Olaya (University of Paris-Sud)H-Index: 3
Last.Antoinette Lemoine (University of Paris-Sud)H-Index: 38
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Ischemia triggers an inflammatory response that precipitates cell death during reperfusion. Several studies have shown that tissues are protected by ischemic preconditioning (IP) consisting of 10 min of ischemia followed by 10 min of reperfusion just before ischemia. The molecular basis of this protective effect is poorly understood. We used cDNA arrays (20K) to compare global gene expression in liver biopsies from living human liver donors who underwent IP (n=7) or not (n=7) just before liver d...