David C. Muller
Imperial College London
Publications 89
#1Ruhina Shirin Laskar (IARC: International Agency for Research on Cancer)H-Index: 6
#2David C. Muller (Imperial College London)H-Index: 17
Last.Ghislaine Scelo (IARC: International Agency for Research on Cancer)H-Index: 32
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Renal cell carcinoma (RCC) has an undisputed genetic component and a stable 2:1 male to female sex ratio in its incidence across populations, suggesting possible sexual dimorphism in its genetic susceptibility. We conducted the first sex-specific genome-wide association analysis of RCC for men (3227 cases, 4916 controls) and women (1992 cases, 3095 controls) of European ancestry from two RCC genome-wide scans and replicated the top findings using an additional series of men (2261 cases, 5852 con...
#1Amy Mullee (IARC: International Agency for Research on Cancer)H-Index: 4
#2Dora Romaguera (Ciber)H-Index: 48
Last.Neil Murphy (IARC: International Agency for Research on Cancer)H-Index: 24
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Importance Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk is unknown and has been understudied in European populations to date. Objective To examine the association between total, sugar-sweetened, and artificially sweetened soft drink consumption and subsequent total and cause-specific mortality. Design, Setting, and Participants This population-based cohort study involved participants (n = 451 743 of the full cohort) in the European Prospecti...
1 CitationsSource
#1Sarah G. DugasH-Index: 1
#2David C. MullerH-Index: 17
Last.Lukas BubendorfH-Index: 59
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#1Heather Ward (Imperial College London)H-Index: 19
#2Julia Whitman (Imperial College London)H-Index: 1
Last.Amanda J. Cross (Imperial College London)H-Index: 48
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Epidemiological studies suggest that haem iron, which is found predominantly in red meat and increases endogenous formation of carcinogenic N-nitroso compounds, may be positively associated with lung cancer. The objective was to examine the relationship between haem iron intake and lung cancer risk using detailed smoking history data and serum cotinine to control for potential confounding. In the European Prospective Investigation into Cancer and Nutrition (EPIC), 416,746 individuals from 10 cou...
1 CitationsSource
#1Perry M. ElliottH-Index: 154
#2Maria Aresu (Imperial College London)H-Index: 3
Last.David C. Muller (Imperial College London)H-Index: 17
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Abstract Background Terrestrial Trunked Radio (TETRA) is used for radiocommunications among the British police forces. Objectives To investigate association of personal radio use and sickness absence among police officers and staff from the Airwave Health Monitoring Study. Methods Participant-level sickness absence records for 26 forces were linked with personal radio use for 32,102 participants. We used multivariable logistic regression to analyse TETRA usage in year prior to enrolment and sick...
#1Naoko Sasamoto (Harvard University)H-Index: 3
#2Ana Babic (Harvard University)H-Index: 12
Last.Kathryn L. Terry (Harvard University)H-Index: 38
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Background: Cancer antigen 125 (CA125) is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study (NEC). We developed linear and dichotomous (≥35 U/mL) CA125 prediction models and exter...
#1Harinakshi Sanikini (Imperial College London)H-Index: 2
#2David C. Muller (Imperial College London)H-Index: 17
Last.Amanda J. Cross (Imperial College London)H-Index: 48
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Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (...
1 CitationsSource
#1Carolina Espina (IARC: International Agency for Research on Cancer)H-Index: 12
#2Linda Bauld (Edin.: University of Edinburgh)H-Index: 3
Last.Joachim Schüz (IARC: International Agency for Research on Cancer)H-Index: 40
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#1Kazufumi Honda (Japan Agency for Medical Research and Development)H-Index: 29
#2Verena Katzke (DKFZ: German Cancer Research Center)H-Index: 22
Last.Rudolph Kaaks (DKFZ: German Cancer Research Center)H-Index: 118
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Recently, we identified unique processing patterns of apolipoprotein A2 (ApoA2) in patients with pancreatic cancer. Our study provides a first prospective evaluation of an ApoA2 isoform (“ApoA2-ATQ/AT”), alone and in combination with carbohydrate antigen 19–9 (CA19-9), as an early detection biomarker for pancreatic cancer. We performed ELISA measurements of CA19-9 and ApoA2-ATQ/AT in 156 patients with pancreatic cancer and 217 matched controls within the European EPIC cohort, using plasma sample...
6 CitationsSource