Simon A. Gayther
Cedars-Sinai Medical Center
CancerOvarian cancerGeneticsMedicineBiology
What is this?
Publications 225
#1Mark Pomerantz (Harvard University)H-Index: 28
#2Xintao Qiu (Harvard University)H-Index: 8
Last. Gavin Ha (Fred Hutchinson Cancer Research Center)H-Index: 40
view all 43 authors...
Epigenetic processes govern prostate cancer (PCa) biology, as evidenced by the dependency of PCa cells on the androgen receptor (AR), a prostate master transcription factor. We generated 268 epigenomic datasets spanning two state transitions—from normal prostate epithelium to localized PCa to metastases—in specimens derived from human tissue. We discovered that reprogrammed AR sites in metastatic PCa are not created de novo; rather, they are prepopulated by the transcription factors FOXA1 and HO...
#1Katharine Brieger (UM: University of Michigan)H-Index: 2
#2Siri Peterson (UM: University of Michigan)
Last. Andrew Berchuck (Duke University)H-Index: 87
view all 51 authors...
Abstract Purpose Prior studies of menopausal hormone therapy (MHT) and ovarian cancer survival have been limited by lack of hormone regimen detail and insufficient sample sizes. To address these limitations, a comprehensive analysis of 6419 post-menopausal women with pathologically confirmed ovarian carcinoma was conducted to examine the association between MHT use prior to diagnosis and survival. Methods Data from 15 studies in the Ovarian Cancer Association Consortium were included. MHT use wa...
#1Yan Dora Zhang (HKU: University of Hong Kong)H-Index: 1
#3Amber N. Hurson (UNC: University of North Carolina at Chapel Hill)H-Index: 1
Last. Kyriaki Michailidou (University of Cambridge)H-Index: 38
view all 90 authors...
Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) and underlying effect-size distribution. All cancers show a high degree of polygenicity, involving at a minimum of thousands of loci. We project that sample si...
1 CitationsSource
#1Siddhartha Kar (UoB: University of Bristol)H-Index: 17
#2Sara Lindstroem (UW: University of Washington)H-Index: 5
Last. Jenny Chang-Claude (DKFZ: German Cancer Research Center)H-Index: 89
view all 97 authors...
We report a meta-analysis of breast, prostate, ovarian, and endometrial cancer genome-wide association data (effective sample size: 237,483 cases/317,006 controls). This identified 465 independent lead variants (P 1Mb from previously identified risk loci for the four cancers and an additional 23 lead variant-cancer associations were novel for one of the cancers. Bayesian models supported pleiotropic effects involving at least two cancers at 222/465 lead variants in 118/192 regions. Gene-level as...
#1Filipe C. Martins (University of Cambridge)H-Index: 5
#2Dominique-Laurent Couturier (University of Cambridge)H-Index: 9
Last. Alexander HeinH-Index: 30
view all 97 authors...
BACKGROUND PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade serous (LGSOC)). We aimed to characterise PTEN expression as a biomarker in epithelial ovarian cancer in a large population-based study. METHODS Tumours from 5400 patients from a multicentre observational, prospective cohort study of the Ovarian Tumour Tissue Analysis Consortium were used to evaluate associations between immunohis...
#1Aline Talhouk (UBC: University of British Columbia)H-Index: 15
#2Joshy GeorgeH-Index: 36
Last. Maria P. Intermaggio (SC: University of Southern California)H-Index: 10
view all 124 authors...
Purpose: Gene-expression-based molecular subtypes of high-grade serous tubo-ovarian cancer (HGSOC), demonstrated across multiple studies, may provide improved stratification for molecularly targeted trials. However, evaluation of clinical utility has been hindered by non-standardized methods which are not applicable in a clinical setting. We sought to generate a clinical-grade minimal gene-set assay for classification of individual tumor specimens into HGSOC subtypes and confirm previously repor...
1 CitationsSource
#1Honglin Song (University of Cambridge)H-Index: 39
#2Ed Dicks (University of Cambridge)H-Index: 40
Last. Teodora Goranova (University of Cambridge)H-Index: 6
view all 60 authors...
PURPOSE The known epithelial ovarian cancer (EOC) susceptibility genes account for less than 50% of the heritable risk of ovarian cancer suggesting that other susceptibility genes exist. The aim of this study was to evaluate the contribution to ovarian cancer susceptibility of rare deleterious germline variants in a set of candidate genes. METHODS We sequenced the coding region of 54 candidate genes in 6385 invasive EOC cases and 6115 controls of broad European ancestry. Genes with an increased ...
#1Huy Q. DinhH-Index: 18
#2Xianzhi Lin (Cedars-Sinai Medical Center)H-Index: 13
Last. Kelly N. Wright (Cedars-Sinai Medical Center)H-Index: 7
view all 18 authors...
The human fallopian tube harbors the cell-of-origin for the majority of high-grade serous ovarian cancers (HGSCs), but its cellular composition, particularly the epithelial component, is poorly characterized. We performed single-cell transcriptomic profiling in 12 primary fallopian specimens from 8 patients, analyzing around 53,000 individual cells to map the major immune, fibroblastic and epithelial cell types present in this organ. We identified 10 epithelial sub-populations, characterized by ...
#1J. Millstein (SC: University of Southern California)
#2T. Budden (University of Manchester)
Last. B. Gilks (UBC: University of British Columbia)
view all 124 authors...
Abstract Background Median overall survival (OS) for women with high-grade serous ovarian cancer (HGSOC) is approximately four years, yet survival varies widely between patients. There are no well-established, gene expression signatures associated with prognosis. The aim of this study was to develop a robust prognostic signature for overall survival in HGSOC patients. Patients and methods Expression of 513 genes, selected from a meta-analysis of 1455 tumours and other candidates, were measured u...
#1Jian Pan (Boston Children's Hospital)H-Index: 1
#2Tiago C. Silva (Cedars-Sinai Medical Center)H-Index: 9
Last. Ling-Wen Ding (NUS: National University of Singapore)H-Index: 24
view all 20 authors...
Gastrointestinal adenocarcinomas (GIAC) of the tubular GI tract including esophagus, stomach, colon, and rectum comprise most GI cancers and share a spectrum of genomic features. However, the unified epigenomic changes specific to GIAC are poorly characterized. Using 907 GIAC samples from The Cancer Genome Atlas, we applied mathematical algorithms to large-scale DNA methylome and transcriptome profiles to reconstruct transcription factor (TF) networks and identify a list of functionally hyperact...