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Judit Moldvay
Semmelweis University
83Publications
11H-index
523Citations
Publications 87
Newest
#1David Dora (Semmelweis University)H-Index: 2
#2Christopher J. Rivard (Anschutz Medical Campus)H-Index: 35
Last.Zsolt Megyesfalvi (Semmelweis University)H-Index: 1
view all 14 authors...
Small cell lung cancer (SCLC) has recently been sub-categorized into neuroendocrine (NE)-high and NE-low subtypes showing 9immune desert9 and 9immune oasis9 phenotypes, respectively. We aimed to characterize the immune cell localization and the microenvironment according to immune checkpoints and NE subtypes in human SCLC tissue samples at the protein level. In this cross-sectional study, we included 32 primary tumors and matched lymph node (LN) metastases of resected early-stage, histologically...
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#1Julian Mohrherr (Medical University of Vienna)H-Index: 1
#2Marcel HaberH-Index: 1
Last.Emilio Casanova (Medical University of Vienna)H-Index: 24
view all 19 authors...
3 CitationsSource
#1Jayendrakishore Tanjore Ramanathan (UH: University of Helsinki)
Last.Pirjo Laakkonen (UH: University of Helsinki)H-Index: 29
view all 11 authors...
Glioblastomas and brain metastases (BM) of solid tumors are the most common central nervous system neoplasms associated with very unfavorable prognosis. In this study, we report the association of Prostate Specific Membrane Antigen with various clinical parameters in a large cohort of primary and secondary brain tumors. A tissue micro array containing 371 cases of ascending grade gliomas pertaining to astrocytic origin, samples of 52 cases of primary lung carcinomas with matching brain metastase...
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#1Zoltan LohinaiH-Index: 5
#2Zsolt MegyesfalviH-Index: 1
Last.Fred R. HirschH-Index: 75
view all 10 authors...
Background: Recent preclinical data suggest that neuroendocrine (NE) subtype of small cell lung cancer (SCLC) has strong therapeutic relevance. NE high tumors are associated with immune desert and NE low tumors are considered to have an immune oasis phenotype. Our aim was to investigate the NE phenotypes of surgically resected SCLC tumors according to inter-tumor heterogeneity. Methods: Expression analysis for 2,560 genes was performed in 32 surgically resected SCLC patients’ primary tumors and ...
1 CitationsSource
#1Krisztina BogosH-Index: 6
#2Zoltán KissH-Index: 8
Last.Judit MoldvayH-Index: 11
view all 18 authors...
Objective: While Hungary is often reported to have the highest incidence and mortality rates of lung cancer, until 2018 no nationwide epidemiology study was conducted to confirm these figures. The objective of this study was to estimate the occurrence of lung cancer in Hungary based on a retrospective review of the National Health Insurance Fund (NHIF) database. Methods: Our retrospective, longitudinal study included patients aged ≥20 years who were diagnosed with lung cancer (ICD-10 C34) betwee...
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#1Áron GhimessyH-Index: 2
Last.Balazs DomeH-Index: 28
view all 18 authors...
Bevacizumab, combined with platinum-based chemotherapy, has been widely used in the treatment of advanced-stage lung adenocarcinoma (LADC). Although KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) mutation is the most common genetic alteration in human LADC and its role in promoting angiogenesis has been well established, its prognostic and predictive role in the above setting remains unclear. The association between KRAS exon 2 mutational status and clinicopathological variables inc...
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#1Judit MoldvayH-Index: 11
#2Vanda TéglásiH-Index: 3
Last.Lilla ReinigerH-Index: 10
view all 14 authors...
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#1Zoltan LohinaiH-Index: 5
#2Zsolt MegyesfalviH-Index: 1
Last.Fred R. HirschH-Index: 75
view all 9 authors...
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#1Dhruva Biswas (UCL: University College London)H-Index: 1
#2Dhruva Biswas (UCL: University College London)H-Index: 1
Last.Charles Swanton (UCL: University College London)H-Index: 66
view all 35 authors...
An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical descriptors such as tumor stage1. Transcriptomic intratumor heterogeneity (RNA-ITH) has been shown to confound existing expression-based biomarkers across multiple cancer types2–6. Here, we analyze multi-region whole-exome and RNA sequencing data for 156 tumor regions from 48 patients enrolled in the TRACERx study to explore and control fo...
3 CitationsSource
#2Judit MoldvayH-Index: 11
Last.Lilla ReinigerH-Index: 10
view all 4 authors...
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