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Citra Nurfarah Zaini Mattar
National University of Singapore
61Publications
13H-index
1,051Citations
Publications 62
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Introduction Labour induction in women with a previous caesarean delivery currently uses vaginal prostaglandin E2 (PGE2), which carries the risks of uterine hyperstimulation and scar rupture. We aim to compare the efficacy of mechanical labour induction using a transcervically applied Foley catheter balloon (FCB) with PGE2 in affected women attempting trial of labour after caesarean (TOLAC). Methods and analysis This single-centre non-inferiority prospective, randomised, open, blinded-endpoint s...
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#1Le Ye Lee (NUS: National University of Singapore)H-Index: 2
#2Guan Huei Lee (NUS: National University of Singapore)H-Index: 3
Last.Marion M. Aw (NUS: National University of Singapore)H-Index: 18
view all 5 authors...
Background Hepatitis B (HBV) transmission may result from in utero transmission. We aimed to determine the correlation between maternal serum and umbilical cord blood HBV DNA levels in infants delivered by chronic HBV-infected mothers and to describe the effect of cord blood viremia on vertical transmission. Methods A prospective cohort of 92 chronic HBV-infected mother-and-child pairs recruited over three years was analyzed. Maternal and cord blood were tested for HBV DNA by real-time PCR. Stan...
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#1Jerry K. Y. Chan (NUS: National University of Singapore)H-Index: 35
#2Irene Gil-Farina (DKFZ: German Cancer Research Center)H-Index: 7
Last.Citra Nurfarah Zaini Mattar (NUS: National University of Singapore)H-Index: 13
view all 14 authors...
Adeno-associated viral vectors (AAVs) achieve stable therapeutic expression without long-term toxicity in adults with hemophilia. To avert irreversible complications in congenital disorders produci...
1 CitationsSource
#2Yi-Wan TanH-Index: 1
Last.Alan W. FlakeH-Index: 70
view all 10 authors...
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#1Abdul Jalil Rufaihah (NUS: National University of Singapore)H-Index: 17
#2Suganya Cheyyatraivendran (NUS: National University of Singapore)H-Index: 3
Last.Dror Seliktar (NUS: National University of Singapore)H-Index: 40
view all 9 authors...
Hydrogel materials have been successfully used as matrices to explore the role of biophysical and biochemical stimuli in directing stem cell behavior. Here, we present our findings on the role of stiffness in guiding fetal mesenchymal stem cell (fMSC) fate determination using semi-synthetic hydrogels made from PEG-fibrinogen (PF). The fMSCs were cultivated in the PF for up to two weeks to study the influence of matrix modulus (i.e., cross-linking density of the PF) on fMSC proliferation, morphol...
1 CitationsSource
#1Hadi Wiputra (NUS: National University of Singapore)H-Index: 3
#2Ching Kit Chen (NUS: National University of Singapore)
Last.Choon Hwai Yap (NUS: National University of Singapore)H-Index: 13
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Blood flow forces are thought to cause congenital heart malformations and influence disease progression. We performed novel investigations of intracardiac fluid mechanics of tetralogy of Fallot (TO...
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#1Shier Nee Saw (NUS: National University of Singapore)H-Index: 3
#2Jess Jia Hwee Tay (NUS: National University of Singapore)
Last.Choon Hwai Yap (NUS: National University of Singapore)H-Index: 13
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Intrauterine growth restriction (IUGR) is a pregnancy complication due to placental dysfunction that prevents the fetus from obtaining enough oxygen and nutrients, leading to serious mortality and morbidity risks. There is no treatment for IUGR despite having a prevalence of 3% in developed countries, giving rise to an urgency to improve our understanding of the disease. Applying biomechanics investigation on IUGR placental tissues can give important new insights. We performed pressure-diameter ...
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#1Giulia Massaro (UCL: University College London)H-Index: 4
#2Citra Nurfarah Zaini Mattar (NUS: National University of Singapore)H-Index: 13
Last.Ahad A. Rahim (UCL: University College London)H-Index: 18
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For inherited genetic diseases, fetal gene therapy offers the potential of prophylaxis against early, irreversible and lethal pathological change. To explore this, we studied neuronopathic Gaucher disease (nGD), caused by mutations in GBA. In adult patients, the milder form presents with hepatomegaly, splenomegaly and occasional lung and bone disease; this is managed, symptomatically, by enzyme replacement therapy. The acute childhood lethal form of nGD is untreatable since enzyme cannot cross t...
27 CitationsSource
#1Shier Nee Saw (NUS: National University of Singapore)H-Index: 3
#2Yu Wei Poh (NUS: National University of Singapore)H-Index: 1
Last.Choon Hwai Yap (NUS: National University of Singapore)H-Index: 13
view all 6 authors...
Significant reductions in blood flow and umbilical diameters were reported in pregnancies affected by intrauterine growth restriction (IUGR) from placental insufficiency. However, it is not known if IUGR umbilical blood vessels experience different hemodynamic wall shear stresses (WSS) compared to normal umbilical vessels. As WSS is known to influence vasoactivity and vascular growth and remodeling, which can regulate flow rates, it is important to study this parameter. In this study, we aim to ...
2 CitationsSource
#1Shier Nee Saw (NUS: National University of Singapore)H-Index: 3
#2Jess Yi Ru Low (NUS: National University of Singapore)H-Index: 1
Last.Choon Hwai Yap (NUS: National University of Singapore)H-Index: 13
view all 7 authors...
Intrauterine Growth Restriction (IUGR) is a serious and prevalent pregnancy complication that is due to placental insufficiency and IUGR babies suffer significantly higher risks of mortality and morbidity. Current detection rate for IUGR is generally poor and thus an alternative diagnostic tool is needed to improve the IUGR detection. Elastography, a non-invasive method that measures the tissue stiffness, has been proposed as one such technique. However, to date, we have limited information on t...
1 CitationsSource
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