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Deva D. Chan
Purdue University
AnatomyBiomedical engineeringMagnetic resonance imagingCartilageDeformation (mechanics)
38Publications
12H-index
351Citations
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Publications 36
Newest
#1Arnold D. Gomez (Johns Hopkins University)H-Index: 5
#2Andrew K. KnutsenH-Index: 12
Last. Jerry L. Prince (Johns Hopkins University)H-Index: 55
view all 8 authors...
Objective: To obtain dense spatiotemporal measurements of brain deformation from two distinct but complementary head motion experiments: linear and rotational accelerations. Methods: This study introduces a strategy for integrating harmonic phase analysis of tagged magnetic resonance imaging (MRI) and finite-element models to extract mechanically representative deformation measurements. The method was calibrated using simulated as well as experimental data, demonstrated in a phantom including da...
1 CitationsSource
#1Lianne Zevenbergen (Katholieke Universiteit Leuven)H-Index: 3
#2Willy Gsell (Katholieke Universiteit Leuven)H-Index: 13
Last. Ilse Jonkers (Katholieke Universiteit Leuven)H-Index: 31
view all 7 authors...
Summary Objective The objective of this study was to evaluate the effect of full-thickness chondral defects on intratissue deformation patterns and matrix constituents in an experimental model mimicking in vivo cartilage-on-cartilage contact conditions. Design Pairs of bovine osteochondral explants, in a unique cartilage-on-cartilage model system, were compressed uniaxially by 350N during 2s loading and 1.4s unloading cycles (≈1700 repetitions). Tissue deformations under quasi-steady state load ...
5 CitationsSource
#1Lianne Zevenbergen (Katholieke Universiteit Leuven)H-Index: 3
#2Willy Gsell (Katholieke Universiteit Leuven)H-Index: 13
Last. Ilse Jonkers (Katholieke Universiteit Leuven)H-Index: 31
view all 9 authors...
Summary Objective This study aims to characterize the deformations in articular cartilage under compressive loading and link these to changes in the extracellular matrix constituents described by magnetic resonance imaging (MRI) relaxation times in an experimental model mimicking in vivo cartilage-on-cartilage contact. Design Quantitative MRI images, T 1 , T 2 and T 1 ρ relaxation times, were acquired at 9.4T from bovine femoral osteochondral explants before and immediately after loading. Two-di...
5 CitationsSource
#1Deva D. Chan (RPI: Rensselaer Polytechnic Institute)H-Index: 12
#2Andrew K. Knutsen (Henry M. Jackson Foundation for the Advancement of Military Medicine)H-Index: 12
Last. Dzung L. Pham (Henry M. Jackson Foundation for the Advancement of Military Medicine)H-Index: 11
view all 9 authors...
3 CitationsSource
#1Lianne ZevenbergenH-Index: 3
#2Willy GsellH-Index: 13
Last. Ilse JonkersH-Index: 31
view all 6 authors...
Objective Full-thickness cartilage defects are commonly found in symptomatic knee patients, and are associated with progressive cartilage degeneration. Although the risk of defect progression to degenerative osteoarthritis is multifactorial, articular cartilage defects change contact mechanics and the mechanical response of tissue adjacent to the defect. The objective of this study was to quantify changes in intra-tissue strain patterns occurring at the defect rim and opposing tissue in an exper...
1 Citations
#1Deva D. Chan (RPI: Rensselaer Polytechnic Institute)H-Index: 12
#2Luyao Cai (Purdue University)H-Index: 5
Last. Corey P. Neu (CU: University of Colorado Boulder)H-Index: 23
view all 7 authors...
Abstract Functional imaging of tissue biomechanics can reveal subtle changes in local softening and stiffening associated with disease or repair, but noninvasive and nondestructive methods to acquire intratissue measures in well-defined animal models are largely lacking. We utilized displacement encoded MRI to measure changes in cartilage deformation following creation of a critical-sized defect in the medial femoral condyle of ovine (sheep) knees, a common in situ and large animal model of tiss...
2 CitationsSource
Sep 10, 2017 in MICCAI (Medical Image Computing and Computer-Assisted Intervention)
#1Arnold D. Gomez (Johns Hopkins University)H-Index: 5
#2Andrew K. KnutsenH-Index: 12
Last. Jerry L. Prince (Johns Hopkins University)H-Index: 55
view all 7 authors...
In traumatic brain injury (TBI), rapid head acceleration resulting from a blow or fall results in detrimental brain tissue deformation. These types of injuries are frequent and can have devastating effects. Understanding the relationship between acceleration and deformation is a challenging and essential step towards designing effective preventive strategies. This study describes patterns of acceleration-induced brain deformation in a group of human volunteers (n = 7). Unlike previous research, ...
Source
#1Deva D. ChanH-Index: 12
#2Jun LiH-Index: 18
Last. Anna PlaasH-Index: 41
view all 6 authors...
Pirfenidone is an anti-inflammatory and anti-fibrotic drug that has shown efficacy in lung and kidney fibrosis. Because inflammation and fibrosis have been linked to the progression of osteoarthritis, we investigated the effects of oral Pirfenidone in a mouse model of cartilage injury, which results in chronic inflammation and joint-wide fibrosis in mice that lack hyaluronan synthase 1 (Has1−/−) in comparison to wild-type. Femoral cartilage was surgically injured in wild-type and Has1−/− mice, a...
2 CitationsSource
#1Arnold D. Gomez (Johns Hopkins University)H-Index: 5
#2Fangxu Xing (Harvard University)H-Index: 8
Last. Jerry L. Prince (Johns Hopkins University)H-Index: 55
view all 6 authors...
Noninvasive measurements of tissue deformation provide biomechanical insights of an organ, which can be used as clinical functional biomarkers or experimental data for validating computational simulations. However, acquisition of 3D displacement information is susceptible to experimental inconsistency and limited scan time. In this research, we describe the process of tracking tagged magnetic resonance imaging (MRI) as enforcing harmonic phase conservation in finite-element (FE) models. This con...
6 CitationsSource
Articular cartilage lines the load-bearing surfaces of long bones and undergoes compositional and structural degeneration during osteoarthritis progression. Contrast enhanced microcomputed tomography (μCT) is being applied to a variety of preclinical models, including the mouse, to map structural and compositional properties in 3-D. The thinness (˜30-50 μm) and high cellularity of mouse articular cartilage presents a significant imaging challenge. Our group previously showed that mouse articular...
7 CitationsSource
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