Kaiyong Cai
Chongqing University
NanotechnologyOrganic chemistryChemistryMaterials scienceTitanium
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Publications 205
#1Jia Tang (Chongqing University)H-Index: 1
#2Yuxin Xing (Chongqing University)H-Index: 5
Last. Kaiyong Cai (Chongqing University)H-Index: 41
view all 6 authors...
Abstract The design and interfacial engineering of DNA functionalized nanosensors with spatially separated but functionally integrated detection units holds a great promise in optical biosensors. In this study, we developed a bi-component hybrid of Janus nanoquencher particles with immobilized enzymes for fluorescence-based “off-on” detection in solution. Specifically, the hybrids consisting of a mesoporous polydopamine nanoparticle (MPDA) side (∼200 nm) asymmetrically attached with a gold (Au) ...
#1Ye He (Chongqing University)H-Index: 7
#2Kun Xu (Chongqing University)H-Index: 1
Last. Guanjun Zhang (Xi'an Jiaotong University)
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Abstract The main task for medical-used titanium researches is to improve the in vivo osteointegration. In addition to mesenchymal stromal cells (MSCs)-osteoblasts lineage, macrophages also undertake irreplaceable roles in the osteointegration process of a titanium implant. The timely recruitment and efficient immunomodulation of macrophages is important. In this work, to firstly endow macrophages recruitment ability and immunomodulation effects to titanium, we fabricated a micro-structured tita...
#1Dong MoH-Index: 1
#2Zhenqiang WangH-Index: 5
Last. Kaiyong CaiH-Index: 41
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The photoluminescence stability of lanthanide complexes (Lnx) in biological media is of utmost significance for the construction of optically encoded nano-on-microbeads in multiplex bioassays. Here, we propose a new type of encoding guests consisting of MOF@MOF nanohybrids, where isomorphic ZIF-8 and ZIF-90 were employed as the core and the shell domain, respectively, to separately modulate the hosting and the protection of inner Lnx guests. Especially, the thin ZIF-90 shell epitaxially grown on...
#1Lu Wang (Chongqing University)
#2Ye He (Chongqing University)H-Index: 7
Last. Kaiyong Cai (Chongqing University)H-Index: 41
view all 8 authors...
Abstract Toll-like receptor (TLR) agonists are the potent stimulants of innate immune system and hold promises as an adjuvant for anticancer immunotherapy. Unfortunately, most of them are limited by a prompt dissemination, and thus caused “wasted inflammation”. Hence, how to restrict their action radius into lymphoid tissues is of great relevance to enhance their efficacy and concomitantly alleviates the side effects. Here, imiquimod (R837), a TLR 7 agonist, was loaded into mesoporous polydopami...
#1Xuemei Yao (Chongqing University)
#2Menghuan Li (Chongqing University)H-Index: 17
Last. Zhong Luo (Chongqing University)H-Index: 35
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Abstract The strategic combination of photodynamic therapy and chemotherapy has emerged as a promising treatment option for various tumor indications, which not only expands our understanding of each individual modality but also reveals new opportunities to achieve superadditive benefit via exploring their internal synergy rather than simple mixing. In this study, dual-emissive upconverting nanoparticle (UCNP) was employed to bridge the two treatment regimens to synergistically reinforce the the...
#1Bailong Tao (Chongqing University)H-Index: 8
#2Weikang Zhao (CQMU: Chongqing Medical University)H-Index: 1
Last. Zengzilu Xia (Chongqing University)H-Index: 2
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Abstract Bone implant-associated infection is one of the major concerns in orthopedics, and may even result in implant failure. To this end, we developed a strategy for the fabrication of an antibacterial coating on titanium (Ti) implants with pH-response to combat bacteria-mediated acidification of the local microenvironment. It includes three steps: first, we synthesized levofloxacin (Levo)-loaded zeolitic imidazolate framework-8 (ZIF-8@Levo) nanoparticles; second, the nanoparticles were loade...
2 CitationsSource
#1Yao Ding (Chongqing University)H-Index: 4
#2Zhang Yuan (Chongqing University)H-Index: 8
Last. Ruirui Liu (SNNU: Shaanxi Normal University)
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Abstract The inherent biological inertness of Ti substrates is a general challenge in orthopedic and dental clinical application. In this study, the strontium-containing phase change lysozyme coating was prepared on titanium via a supramolecular self-assembly method for accelerating osseointegration. Successful preparation of the Sr-incorporated lysozyme nanofilm onto the Ti substrate (Ti-Ly-Sr) was proved by tests of scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray photo...
#1Ke Li (Chongqing University)H-Index: 8
#2Menghuan Li (Chongqing University)H-Index: 9
Last. Kaiyong Cai (Chongqing University)H-Index: 41
view all 10 authors...
The chemotherapeutic efficacy of paclitaxel against hypoxic tumors is usually unsatisfactory, which is partially due to the so-called hypoxia-induced drug resistance. The mechanism of hypoxia-induced resistance is primarily associated with hypoxia-inducible factor 1alpha (HIF-1alpha), which is an oxygen-sensitive transcriptional activator coordinating the cellular response to hypoxia. Apigenin is a natural occurring HIF-1alpha inhibitor that can suppress the expression of HIF-1alpha through mult...
#1Lu Lu (Chongqing University)H-Index: 4
#2Bing Li (Chongqing University)
Last. Kaiyong Cai (Chongqing University)H-Index: 41
view all 8 authors...
Tumor cells targeting drug delivery system is of great importance to anti-tumor therapy in clinic. Owing to the overexpression of asialoglycoprotein receptor (ASGPR) on the hepatoma carcinoma cell membrane, conjugating of lactose on the surface of drug delivery system has already shown significant advantages of targeting tumor cells. In this work, a disulfide bond-conjugated prodrug targeting delivery system consisting of camptothecin (CPT) and lactose (LA) had been synthesized, and this conjuga...
#1Yulu Yang (Chongqing University)H-Index: 1
#2Bailong Tao (Chongqing University)H-Index: 8
Last. Kaiyong Cai (Chongqing University)H-Index: 41
view all 10 authors...
After bone tumor resection, the large bony deficits are commonly reconstructed with Ti based metallic endoprosthesis which provide immediate stable fixation and allow early ambulation and weight bearing. However, when used in osteosarcoma resection, Ti implant-relative infection and tumor recurrence were recognized as the two critical factors for implantation failure. Hence, in this work, a novel zinc oxide nanoparticle decorating with naringin was prepared and immobilized onto Ti substrate. The...