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Min Jeong Choi
Chungnam National University
EndocrinologyAdipose tissueInsulin resistanceOxidative phosphorylationBiology
14Publications
8H-index
255Citations
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Publications 15
Newest
#1Min Jeong Choi (CNU: Chungnam National University)H-Index: 8
#2Saet-Byel Jung (CNU: Chungnam National University)H-Index: 14
Last. Minho Shong (CNU: Chungnam National University)H-Index: 38
view all 16 authors...
Mitochondrial oxidative phosphorylation (OxPhos) is essential for energy production and survival. However, the tissue-specific and systemic metabolic effects of OxPhos function in adipocytes remain incompletely understood. We used adipocyte-specific Crif1 (also known as Gadd45gip1) knockout (AdKO) mice with decreased adipocyte OxPhos function. AdKO mice fed a normal chow or high-fat diet were evaluated for glucose homeostasis, weight gain and energy expenditure (EE). RNA sequencing of adipose ti...
Source
#1Ju Hee LeeH-Index: 10
#2Ji Min KimH-Index: 5
Last. Hyun-Jin KimH-Index: 36
view all 11 authors...
1 CitationsSource
#1Saet Byel Jung (CNU: Chungnam National University)H-Index: 5
#2Min Jeong Choi (CNU: Chungnam National University)H-Index: 8
Last. Minho Shong (CNU: Chungnam National University)H-Index: 38
view all 19 authors...
Oxidative functions of adipose tissue macrophages control the polarization of M1-like and M2-like phenotypes, but whether reduced macrophage oxidative function causes systemic insulin resistance in vivo is not clear. Here, we show that mice with reduced mitochondrial oxidative phosphorylation (OxPhos) due to myeloid-specific deletion of CR6-interacting factor 1 (Crif1), an essential mitoribosomal factor involved in biogenesis of OxPhos subunits, have M1-like polarization of macrophages and syste...
11 CitationsSource
#1Yea Eun KangH-Index: 8
#2Jin Man KimH-Index: 18
Last. Minho ShongH-Index: 38
view all 16 authors...
// Yea Eun Kang 1, * , Jin-Man Kim 2, 3, * , Koon Soon Kim 1, 2, * , Joon Young Chang 2 , Mingyu Jung 2 , Junguee Lee 4 , Shinae Yi 2 , Hyeon Woo Kim 2 , Jung Tae Kim 2 , Kyungmin Lee 2 , Min Jeong Choi 2 , Seul Ki Kang 2 , Seong Eun Lee 2 , Hyon-Seung Yi 1 , Bon Seok Koo 2, 5 and Minho Shong 1, 2 1 Department of Endocrinology and Metabolism, College of Medicine, Chungnam National University, Daejeon 35015, South Korea 2 Department of Medical Science, College of Medicine, Chungnam National Unive...
1 CitationsSource
#1Seong Eun Lee (CNU: Chungnam National University)H-Index: 10
#2Seul Gi Kang (CNU: Chungnam National University)H-Index: 4
Last. Minho Shong (CNU: Chungnam National University)H-Index: 38
view all 14 authors...
T-helper type 2 (Th2) cytokines, including interleukin (IL)-13 and IL-4, produced in adipose tissue, are critical regulators of intra-adipose and systemic lipid and glucose metabolism. Furthermore, IL-13 is a potential therapy for insulin resistance in obese mouse models. Here, we examined mediators produced by adipocytes that are responsible for regulating systemic glucose homeostasis in response to Th2 cytokines. We used RNA sequencing data analysis of cultured adipocytes to screen factors sec...
10 CitationsSource
#1Seul Gi KangH-Index: 4
#2Hyon-Seung YiH-Index: 13
Last. Minho ShongH-Index: 38
view all 18 authors...
7 CitationsSource
#1Hyo Kyun Chung (CNU: Chungnam National University)H-Index: 21
#2Dongryeol Ryu (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 24
Last. Minho Shong (CNU: Chungnam National University)H-Index: 38
view all 22 authors...
Reduced mitochondrial electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and –non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded protein response (UPRmt), an adaptive stress-response pathway activated by mitochondrial proteotoxic stress. Using mice with skeletal muscle–specific deficiency of Crif1 (muscle-specific knockout [MKO]), an integral protein of the large mitorib...
57 CitationsSource
#1Yea Eun Kang (CNU: Chungnam National University)H-Index: 8
#2Ji Min Kim (CNU: Chungnam National University)H-Index: 5
Last. Hyun-Jin Kim (CNU: Chungnam National University)H-Index: 36
view all 14 authors...
The roles of adipokines, proinflammatory cytokines, and adipose tissue macrophages in obesity-associated insulin resistance have been explored in both animal and human studies. However, our current understanding of obesity-associated insulin resistance relies on studies of artificial metabolic extremes. The purpose of this study was to explore the roles of adipokines, proinflammatory cytokines, and adipose tissue macrophages in human patients with modest obesity and early metabolic dysfunction. ...
84 CitationsSource
#1Min Hee Lee (CNU: Chungnam National University)H-Index: 8
#2Jung Uee Lee (Catholic University of Korea)H-Index: 7
Last. Minho Shong (CNU: Chungnam National University)H-Index: 38
view all 19 authors...
Adult thyroid dysfunction is a common endocrine disorder associated with an increased risk of cardiovascular disease and mortality. A recent epidemiologic study revealed a link between obesity and increased prevalence of hypothyroidism. It is conceivable that excessive adiposity in obesity might lead to expansion of the interfollicular adipose (IFA) depot or steatosis in thyroid follicular cells (thyroid steatosis, TS). In this study, we investigated the morphological and functional changes in t...
14 CitationsSource
#1Yong Kyung Kim (CNU: Chungnam National University)H-Index: 12
#2Kyong Hye Joung (CNU: Chungnam National University)H-Index: 9
Last. Minho Shong (CNU: Chungnam National University)H-Index: 38
view all 18 authors...
Aim/hypothesis Although mitochondrial oxidative phosphorylation (OxPhos) dysfunction is believed to be responsible for beta cell dysfunction in insulin resistance and mitochondrial diabetes, the mechanisms underlying progressive beta cell failure caused by defective mitochondrial OxPhos are largely unknown.
6 CitationsSource
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