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P. E. Van den Steen
Rega Institute for Medical Research
Matrix metalloproteinaseImmunologyBiochemistryBiologyCell biology
18Publications
7H-index
435Citations
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#1Thao-Thy Pham (Rega Institute for Medical Research)H-Index: 5
#2Chuchard Punsawad (WU.: Walailak University)H-Index: 9
Last. P. E. Van den Steen (Rega Institute for Medical Research)H-Index: 7
view all 6 authors...
Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an understudied complication of malaria and is characterized by pulmonary inflammation and disruption of the alveolar-capillary membrane. Its pathogenesis remains poorly understood. Since endothelial activation plays an important role in other malarial complications, the expression of two endothelial activation markers, von Willebrand factor (VWF) and angiopoietin-2 (ANG-2), was investigated in the lungs of patients with MA-ARDS...
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#1Noemí Aguilera-Montilla (CSIC: Spanish National Research Council)H-Index: 7
#2Elvira Bailón (CSIC: Spanish National Research Council)H-Index: 6
Last. Angeles García-Pardo (CSIC: Spanish National Research Council)H-Index: 25
view all 11 authors...
Abstract Increased angiogenesis is commonly observed in chronic lymphocytic leukemia (CLL) tissues in correlation with advanced disease. CLL cells express pro- and anti-angiogenic genes and acquire a pro-angiogenic pattern upon interaction with the microenvironment. Because MMP-9 (a microenvironment component) plays important roles in solid tumor angiogenesis, we have studied whether MMP-9 influenced the angiogenic pattern in CLL cells. Immunofluorescence analyses confirmed the presence of MMP-9...
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#1Leen Vandermosten (Rega Institute for Medical Research)H-Index: 4
#2Ilse Vanhorebeek (Katholieke Universiteit Leuven)H-Index: 41
Last. P. E. Van den Steen (Rega Institute for Medical Research)H-Index: 7
view all 5 authors...
During malaria, the hypothalamic–pituitary–adrenal (HPA) axis is activated and glucocorticoid (GC) levels are increased, but their essential roles have been largely overlooked. GCs are decisive for systemic regulation of vital processes such as immune responses, vascular function, and metabolism, which are crucial in malaria. Here, we introduce GCs in general, followed by their versatile roles for disease tolerance in malaria. A complementary comparison is provided with their role in sepsis. Fin...
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#1Noemí Aguilera-Montilla (CSIC: Spanish National Research Council)H-Index: 7
#2Elvira Bailón (CSIC: Spanish National Research Council)H-Index: 6
Last. Angeles García-Pardo (CSIC: Spanish National Research Council)H-Index: 25
view all 11 authors...
We previously showed that MMP-9 contributes to CLL pathology by regulating cell survival and migration and that, when present at high levels, MMP-9 induces cell arrest. To further explore the latter function, we studied whether MMP-9 influences the gene-expression profile in CLL. Microarray analyses rendered 131 differentially expressed genes in MEC-1 cells stably transfected with MMP-9 (MMP-9-cells) versus cells transfected with empty vector (Mock-cells). Ten out of twelve selected genes were a...
2 CitationsSource
#1Diletta Scaccabarozzi (University of Milan)H-Index: 7
#2Katrien Deroost (Rega Institute for Medical Research)H-Index: 9
Last. Donatella Taramelli (University of Milan)H-Index: 39
view all 8 authors...
Cerebral malaria and severe anaemia are the most common deadly complications of malaria, and are often associated, both in paediatric and adult patients, with hepatopathy, whose pathogenesis is not well characterized, and sometimes also with acute respiratory distress syndrome (ARDS). Here, two species of murine malaria, the lethal Plasmodium berghei strain NK65 and self-healing Plasmodium chabaudi strain AS which differ in their ability to cause hepatopathy and/or ARDS were used to investigate ...
2 CitationsSource
#1Elvira Bailón (CSIC: Spanish National Research Council)H-Index: 6
#2Noemí Aguilera-Montilla (CSIC: Spanish National Research Council)H-Index: 7
Last. Angeles García-Pardo (CSIC: Spanish National Research Council)H-Index: 25
view all 8 authors...
Abstract We previously showed that MMP-9 overexpression impairs migration of primary CLL cells and MEC-1 cells transfected with MMP-9. To determine the contribution of non-proteolytic activities to this effect we generated MEC-1 transfectants stably expressing catalytically inactive MMP-9MutE (MMP-9MutE-cells). In xenograft models in mice, MMP-9MutE-cells showed impaired homing to spleen and bone marrow, compared to cells transfected with empty vector (Mock-cells). In vitro transendothelial and ...
2 CitationsSource
#1Leen Vandermosten (Rega Institute for Medical Research)H-Index: 4
#2C. De Geest (Rega Institute for Medical Research)H-Index: 1
Last. P. E. Van den Steen (Rega Institute for Medical Research)H-Index: 7
view all 8 authors...
Malaria is a global disease associated with considerable mortality and morbidity. An appropriately balanced immune response is crucial in determining the outcome of malarial infection. The glucocorticoid (GC) metabolising enzyme, 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1) converts intrinsically inert GCs into active GCs. 11β-HSD1 shapes endogenous GC action and is immunomodulatory. We investigated the role of 11β-HSD1 in two mouse models of malaria. 11β-HSD1 deficiency did not affect survival...
4 CitationsSource
#1Karolina Zielinska (Rega Institute for Medical Research)H-Index: 2
#2Lode De Cauwer (UGent: Ghent University)H-Index: 7
Last. P. E. Van den Steen (Rega Institute for Medical Research)H-Index: 7
view all 10 authors...
Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an often lethal complication of malaria. Currently, no adequate therapy for this syndrome exists. Although glucocorticoids (GCs) have been used to improve clinical outcome of ARDS, their therapeutic benefits remain unclear. We previously developed a mouse model of MA-ARDS, in which dexamethasone treatment revealed glucocorticoid resistance. In the present study, we investigated glucocorticoid sensitivity of mouse microvascular l...
3 CitationsSource
#1Zheng Qiu (CPU: China Pharmaceutical University)H-Index: 5
#2Jianghai Chen (TJMC: Tongji Medical College)H-Index: 1
Last. Jialiang Hu (MOE: Chinese Ministry of Education)H-Index: 12
view all 7 authors...
Endotoxin shock is a life-threatening disorder, associated with the rapid release of neutrophil enzymes, including neutrophil collagenase/matrix metalloproteinase-8 (MMP-8) and gelatinase B/matrix metalloproteinase-9 (MMP-9). After activation, these enzymes cleave extracellular matrix components and cytokines and thus may contribute to shock syndrome development. MMP inhibitors have been suggested as immunotherapy of endotoxin shock. However, little is known about the therapeutic time window of ...
5 CitationsSource
#1Katrien Deroost (Rega Institute for Medical Research)H-Index: 9
#2Natacha Lays (Rega Institute for Medical Research)H-Index: 6
Last. P. E. Van den Steen (Rega Institute for Medical Research)H-Index: 7
view all 11 authors...
Malaria is a global disease that clinically affects more than two hundred million people annually. Despite the availability of effective antimalarials, mortality rates associated with severe complications are high. Hepatopathy is frequently observed in patients with severe malarial disease and its pathogenesis is poorly understood. Previously, we observed high amounts of hemozoin or malaria pigment in livers from infected mice. In this study, we investigated whether hemozoin is associated with l...
21 CitationsSource
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