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Jean-François Berret
Paris Diderot University
182Publications
45H-index
5,063Citations
Publications 173
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Inhaled nanoparticles (< 100 nm) reaching the deep lung region first interact with the pulmonary surfactant, a thin lipid film lining the alveolar epithelium. To date, most biophysical studies have focused on particle induced modifications of the film interfacial properties. In comparison, there is less work on the surfactant bulk properties, and on their changes upon particle exposure. Here we study the viscoelastic properties of a biomimetic pulmonary surfactant in the presence of various engi...
#1Ana Mateos‐Maroto (Complutense University of Madrid)H-Index: 2
#2Francisco Ortega (Complutense University of Madrid)H-Index: 30
Last.Fernando Martinez-Pedrero (Complutense University of Madrid)H-Index: 8
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#1Ana Mateos‐Maroto (Complutense University of Madrid)H-Index: 2
#2Francisco Ortega (Complutense University of Madrid)H-Index: 30
Last.Fernando Martinez-Pedrero (Complutense University of Madrid)H-Index: 8
view all 5 authors...
Source
#1F. Mousseau (Paris Diderot University)H-Index: 5
#2Jean-François Berret (Paris Diderot University)H-Index: 45
Last.Evdokia K. Oikonomou (Paris Diderot University)H-Index: 2
view all 3 authors...
Amphiphilic molecules such as surfactants, lipids, and block copolymers can be assembled into bilayers and form vesicles. Fluorescent membrane labeling methods require the use of dye molecules that can be inserted into the bilayers at different stages of synthesis. To our knowledge, there is no generalized method for labeling preformed vesicles. Herein, we develop a versatile protocol that is suitable to both surfactant and lipid preformed vesicles and requires no separation or purification step...
1 CitationsSource
#1F. Mousseau (Paris Diderot University)H-Index: 5
Last.Evdokia K. Oikonomou (Paris Diderot University)H-Index: 2
view all 3 authors...
Amphiphilic molecules such as surfactants, lipids and block copolymers can be assembled into bilayers and form vesicles. Fluorescent membrane labeling methods require the use of dye molecules that can be inserted in the bilayers at different stages of the synthesis. To our knowledge there is no generalized method for labeling preformed vesicles. Herein we develop a versatile protocol that is suitable to both surfactant and lipid preformed vesicles and requires no separation or purification steps...
#1L.P.A. Thai (Paris Diderot University)
#2F. Mousseau (Paris Diderot University)H-Index: 5
Last.Jean-François Berret (Paris Diderot University)H-Index: 45
view all 4 authors...
Abstract The role of pulmonary surfactant is to reduce the surface tension in the lungs and to facilitate breathing. Surfactant replacement therapy (SRT) aims at bringing a substitute by instillation into the airways, a technique that has proven to be efficient and lifesaving for preterm infants. Adapting this therapy to adults requires to scale the administered dose to the patient body weight and to increase the lipid concentration, whilst maintaining its surface and flow properties similar. He...
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#1Mojtaba Falahati (IAU: Islamic Azad University)H-Index: 13
#2Farnoosh AttarH-Index: 8
Last.Ali Akbar Saboury (UT: University of Tehran)H-Index: 37
view all 7 authors...
Abstract Nanoparticle (NP)–protein complexes exhibit the “correct identity” of NP in biological media. Therefore, protein–NP interactions should be closely explored to understand and modulate the nature of NPs in medical implementations. This review focuses mainly on the physicochemical parameters such as dimension, surface chemistry, morphology of NPs, and influence of pH on the formation of protein corona and conformational changes of adsorbed proteins by different kinds of techniques. Also, t...
4 CitationsSource
#1V. Baldim (Paris Diderot University)H-Index: 1
#2Nicolas BiaH-Index: 1
Last.Jean-François Berret (Paris Diderot University)H-Index: 45
view all 5 authors...
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#1V. BaldimH-Index: 1
#2A. GraillotH-Index: 3
Last.Jean-François BerretH-Index: 45
view all 5 authors...
For applications in nanomedicine, particles need to be functionalized to prevent protein corona formation and or aggregation. Most advanced strategies take advantage of functional polymers and assembly techniques. Nowadays there is an urgent need for coatings that are tailored according to a broad range of surfaces and that can be produced on a large scale. Herein, we synthesize mono- and multi-phosphonic acid based poly(ethylene glycol) (PEG) polymers with the objective of producing efficient c...
#1F. MousseauH-Index: 5
Last.Jean-François BerretH-Index: 45
view all 5 authors...
The impact of nanomaterials on lung fluids, or on the plasma membrane of living cells, has prompted researchers to examine the interactions between nanoparticles and lipid vesicles. Recent studies have shown that nanoparticle-lipid interaction leads to a broad range of structures including supported lipid bilayers (SLB), particles adsorbed at the surface or internalized inside vesicles, and mixed aggregates. Currently, there is a need to have simple protocols that can readily evaluate the struct...
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