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Candelaria Vergara
Johns Hopkins University
ImmunologyAsthmaGeneticsMedicineBiology
59Publications
19H-index
973Citations
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Publications 58
Newest
#1Nicolas Vince (University of Nantes)H-Index: 10
#2Sophie Limou (French Institute of Health and Medical Research)H-Index: 18
Last. Sameer Chavan (University of Colorado Denver)H-Index: 3
view all 31 authors...
Abstract Background Asthma is a complex chronic inflammatory disease of the airways. Association studies between HLA and asthma were first reported in the 1970’s, and yet, the precise role of HLA alleles in asthma is not fully understood. Numerous genome-wide association studies were recently conducted on asthma, but were always limited to simple genetic markers (SNPs) and not complex HLA gene polymorphisms (alleles/haplotypes), therefore not capturing the biological relevance of this complex lo...
1 CitationsSource
#1Candelaria Vergara (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 19
#2Chloe L. Thio (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 45
Last. Priya Duggal (Johns Hopkins University)H-Index: 34
view all 30 authors...
Background & Aims Spontaneous clearance of hepatitis C virus (HCV) occurs in approximately 30% of infected persons and less often in populations of African ancestry. Variants in major histocompatibility complex (MHC) and in interferon lambda genes are associated with spontaneous HCV clearance, but there have been few studies of these variants in persons of African ancestry. We performed a dense multi-ancestry genome-wide association study of spontaneous clearance of HCV, focusing on individuals ...
2 CitationsSource
#1Michelle Daya (University of Colorado Denver)H-Index: 13
#2Nicholas Rafaels (University of Colorado Denver)H-Index: 32
Last. Kathleen C. Barnes (University of Colorado Denver)H-Index: 62
view all 65 authors...
Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find ...
13 CitationsSource
#1Michelle Daya (CU: University of Colorado Boulder)H-Index: 13
#2Nicholas Rafaels (CU: University of Colorado Boulder)H-Index: 32
Last. Kathleen C. Barnes (CU: University of Colorado Boulder)H-Index: 62
view all 65 authors...
Source
#1Rachel M. Sherman (Johns Hopkins University)H-Index: 5
#2Juliet Forman (HMC: Harvey Mudd College)H-Index: 2
Last. Steven L. SalzbergH-Index: 131
view all 46 authors...
In the version of this article initially published, the statement “there are no pan-genomes for any other animal or plant species” was incorrect. The statement has been corrected to “there are no reported pan-genomes for any other animal species, to our knowledge.” We thank David Edwards for bringing this error to our attention. The error has been corrected in the HTML and PDF versions of the article.
2 CitationsSource
#1Rachel M. Sherman (Johns Hopkins University)H-Index: 5
#2Juliet Forman (HMC: Harvey Mudd College)H-Index: 2
Last. Steven L. SalzbergH-Index: 131
view all 46 authors...
We used a deeply sequenced dataset of 910 individuals, all of African descent, to construct a set of DNA sequences that is present in these individuals but missing from the reference human genome. We aligned 1.19 trillion reads from the 910 individuals to the reference genome (GRCh38), collected all reads that failed to align, and assembled these reads into contiguous sequences (contigs). We then compared all contigs to one another to identify a set of unique sequences representing regions of th...
75 CitationsSource
#1Candelaria Vergara (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 19
#2Samantha M. Bomotti (Johns Hopkins University)H-Index: 2
Last. Priya Duggal (Johns Hopkins University)H-Index: 34
view all 8 authors...
: Refractive errors, myopia, and hyperopia are common visual disorders greatly affecting older individuals. Refraction is determined by genetic factors but only a small percentage of its variation has been explained. We performed a genetic association analysis with three ocular phenotypes: spherical equivalent (a continous measure of refraction), axial length, and corneal curvature in 1,871 European-Americans from the Beaver Dam Eye Study. Individuals were genotyped on the Illumina exome array a...
1 CitationsSource
#1Candelaria Vergara (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 19
#2Margaret M. Parker (Brigham and Women's Hospital)H-Index: 20
Last. Priya Duggal (Johns Hopkins University)H-Index: 34
view all 7 authors...
Genotype imputation estimates unobserved genotypes from genome-wide makers, to increase genome coverage and power for genome-wide association studies. Imputation has been successful for European ancestry populations in which very large reference panels are available. Smaller subsets of African descent populations are available in 1000 Genomes (1000G), the Consortium on Asthma among African ancestry Populations in the Americas (CAAPA) and the Haplotype Reference Consortium (HRC). We compared the ...
11 CitationsSource
#1Ryan Santos Costa (UFBA: Federal University of Bahia)H-Index: 7
#2Camila Alexandrina Figueiredo (UFBA: Federal University of Bahia)H-Index: 18
Last. Kathleen C. Barnes (Johns Hopkins University)H-Index: 62
view all 13 authors...
Wellcome Trust, the HCPC Latin America Excellence Centre Programme (072405/Z/03/Z), and the Brazilian agency Conselho Nacional de Desenvolvimento Cientifico e TecnologicoeCNPq
8 CitationsSource
#1Michelle Daya (University of Colorado Denver)H-Index: 13
#2Nicholas Rafaels (University of Colorado Denver)H-Index: 32
Last. Kathleen C. Barnes (University of Colorado Denver)H-Index: 62
view all 56 authors...
BACKGROUND : Asthma is a complex disease with striking disparities across racial and ethnic groups, which may be partly attributable to genetic factors. One of the main goals of the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) is to discover genes conferring risk to asthma in populations of African descent. METHODS : We performed a genome-wide meta-analysis of asthma across 11 CAAPA datasets (4,827 asthma cases and 5,397 controls), genotyped on the African Dias...
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