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Dieter Egli
Columbia University
94Publications
34H-index
4,237Citations
Publications 94
Newest
Published on Mar 21, 2019in Scientific Reports 4.12
Kylie S. Foo3
Estimated H-index: 3
(Karolinska Institutet),
Alicja A. Skowronski6
Estimated H-index: 6
(Columbia University)
+ 7 AuthorsRudolph L. Leibel76
Estimated H-index: 76
(Columbia University)
Type I diabetes (T1D) is caused by immune-mediated destruction of pancreatic beta cells. This process is triggered, in part, by specific (aa 9–23) epitopes of the insulin Β chain. Previously, fish insulins were used clinically in patients allergic to bovine or porcine insulin. Fish and human insulin differ by two amino acids in the critical immunogenic region (aa 9–23) of the B chain. We hypothesized that β cells synthesizing fish insulin would be less immunogenic in a mouse model of T1D. Transg...
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Published on Mar 1, 2019in Cell Metabolism 20.57
Peng Wang6
Estimated H-index: 6
(Icahn School of Medicine at Mount Sinai),
Esra Karakose2
Estimated H-index: 2
(Icahn School of Medicine at Mount Sinai)
+ 16 AuthorsKaren K. Takane3
Estimated H-index: 3
(Icahn School of Medicine at Mount Sinai)
Summary Small-molecule inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) induce human beta cells to proliferate, generating a labeling index of 1.5%–3%. Here, we demonstrate that combined pharmacologic inhibition of DYRK1A and transforming growth factor beta superfamily (TGFβSF)/SMAD signaling generates remarkable further synergistic increases in human beta cell proliferation (average labeling index, 5%–8%, and as high as 15%–18%), and increases in both mouse and human beta ce...
3 Citations Source Cite
Published on Feb 14, 2019in bioRxiv
Daniela Georgieva1
Estimated H-index: 1
(Columbia University),
Qian Liu1
Estimated H-index: 1
(Children's Hospital of Philadelphia)
+ 1 AuthorsDieter Egli34
Estimated H-index: 34
(Columbia University)
DNA synthesis is a fundamental requirement for cell proliferation and DNA repair, but no tools exist to identify the location, direction and speed of replication forks with base pair resolution. Mammalian cells have the ability to incorporate thymidine analogs along with the natural A, T, G and C bases during DNA synthesis, which allows for labelling of replicating or repaired DNA. Most sequencing platforms rely on base-pairing to identify the four canonical nucleotides, and are thus unable to d...
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Published on Feb 1, 2019in BMC Genomics 3.73
Qian Liu1
Estimated H-index: 1
(Children's Hospital of Philadelphia),
Daniela Georgieva1
Estimated H-index: 1
(Columbia University)
+ 1 AuthorsKai Wang55
Estimated H-index: 55
(University of Pennsylvania)
Recent advances in single-molecule sequencing techniques, such as Nanopore sequencing, improved read length, increased sequencing throughput, and enabled direct detection of DNA modifications through the analysis of raw signals. These DNA modifications include naturally occurring modifications such as DNA methylations, as well as modifications that are introduced by DNA damage or through synthetic modifications to one of the four standard nucleotides. To improve the performance of detecting DNA ...
3 Citations Source Cite
Published on Sep 15, 2018in Journal of Immunology 4.54
Hideki Ogura13
Estimated H-index: 13
(Yale University),
Paula Preston-Hurlburt15
Estimated H-index: 15
(Yale University)
+ 8 AuthorsAndrea K. Steck23
Estimated H-index: 23
(University of Colorado Denver)
Type 1 diabetes (T1D) is most likely caused by killing of β cells by autoreactive CD8 + T cells. Methods to isolate and identify these cells are limited by their low frequency in the peripheral blood. We analyzed CD8 + T cells, reactive with diabetes Ags, with T cell libraries and further characterized their phenotype by CyTOF using class I MHC tetramers. In the libraries, the frequency of islet Ag–specific CD45RO + IFN-γ + CD8 + T cells was higher in patients with T1D compared with healthy cont...
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Published on Sep 1, 2018in Fertility and Sterility 4.80
C. Fischer (Columbia University Medical Center), R. Prosser (Columbia University Medical Center)+ 7 AuthorsDieter Egli34
Estimated H-index: 34
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Published on Sep 1, 2018in Fertility and Sterility 4.80
C. Fischer (Columbia University Medical Center), Robert W. Prosser8
Estimated H-index: 8
(Columbia University)
+ 1 AuthorsDieter Egli34
Estimated H-index: 34
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Published on Aug 1, 2018in Transplantation 3.96
Jon S. Odorico37
Estimated H-index: 37
(University of Wisconsin-Madison),
James F. Markmann52
Estimated H-index: 52
(Harvard University)
+ 33 AuthorsLuhan Yang1
Estimated H-index: 1
Beta cell replacement has the potential to restore euglycemia in patients with insulin dependent diabetes. While great progress has been made in establishing allogeneic islet transplantation from deceased donors as the standard of care for those with the most labile diabetes, it is also clear that the deceased donor organ supply cannot possibly treat all those who could benefit from restoration of a normal beta cell mass, especially if immunosuppression were not required. Against this background...
3 Citations Source Cite
Published on Aug 1, 2018in Nature 41.58
Dieter Egli34
Estimated H-index: 34
(Columbia University),
Michael V. Zuccaro1
Estimated H-index: 1
(Columbia University)
+ 3 AuthorsMaria Jasin76
Estimated H-index: 76
(Memorial Sloan Kettering Cancer Center)
Many human diseases have an underlying genetic component. The development and application of methods to prevent the inheritance of damaging mutations through the human germline could have significant health benefits, and currently include preimplantation genetic diagnosis and carrier screening. Ma et al. take this a step further by attempting to remove a disease mutation from the human germline through gene editing (1). They assert the following advances: (i) the correction of a pathogenic gene ...
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