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Leonard Saiegh
Technion – Israel Institute of Technology
EndocrinologyStimulationAdrenocorticotropic hormoneDiabetes mellitusMedicine
16Publications
5H-index
81Citations
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Publications 16
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#1Leonard SaieghH-Index: 5
Osteoporosis in rheumatic diseases is a very well-known complication. The possible combination of age-related bone loss, sarcopenia, potential frailty, reduced physical activity, joint deformities and increased risk of falls, systemic inflammatory disease, and glucocorticoid treatment, places elderly patients with rheumatic diseases at extremely high risk for osteoporotic fracture. All elderly patients with rheumatic diseases, regardless of other fracture risks, should be considered for non-phar...
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Objective Primary bilateral macronodular adrenal hyperplasia (PBMAH) is characterized by benign bilateral enlarged adrenal masses, causing Cushing’s syndrome (CS). The aim of the current article is to define the role of unilateral adrenalectomy (UA) in treating patients with CS related to PBMAH. Methods A PubMed database search was conducted to identify articles reporting UA to treat PBMAH. We also report cases of PBMAH from our medical center treated by UA. Results A total number of 71 cases of...
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#1Leonard SaieghH-Index: 5
Last. Jacob BejarH-Index: 13
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Abstract Aim: Some resected adrenal-confined adrenocortical carcinomas metastasize and others not. The present study was designed to evaluate the expression of metallothionein protein (MT) and minichromosome maintenance protein-2 (MCM2) in adrenocortical carcinomas and adrenocortical adenomas, and to test the correlation between this and adrenocortical carcinoma aggressiveness. Materials and methods: The study comprised 14 patients operated on for adrenocortical carcinoma, 15 operated on for adr...
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#1Afif Nakhleh (Rambam Health Care Campus)H-Index: 2
#2Naim Shehadeh (Rambam Health Care Campus)H-Index: 23
Last. Leonard SaieghH-Index: 5
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#1Asala Abu-AhmadH-Index: 1
#2Carmela ShechnerH-Index: 10
Last. Leonard SaieghH-Index: 5
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BACKGROUND: Earlier research on 1 μg low-dose test (LDT) performed using 20.3 cm plastic IV tubing on healthy volunteers, has shown that afternoon testing was associated with a sevenfold increased likelihood of failing the test. Nevertheless, it has been claimed that subnormal cortisol response using plastic tubes might have resulted from cosyntropin adherence to the tube and, thus, loss of the delivered dosage. Following from our previous study, which showed that using a short (2.5 cm) plastic ...
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#1Safwat OdehH-Index: 1
#2Majed OdehH-Index: 28
Last. Leonard SaieghH-Index: 5
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AIMS: To examine statistical correlation between mSASSS and serum levels of testosterone in males suffering from AS. BACKGROUND: Ankylosing spondylitis (AS) is a chronic progressive inflammatory rheumatic disease primarily involving sacroiliac joints and spine. Structural damage, caused by AS, manifests with development of vertebral syndesmophytes and can be calculated as units of modified Spinal Ankylosing Spondylitis Syndesmophyte Score (mSASSS). The rate of growth of spinal syndesmophytes dif...
1 Citations
#1Leonard SaieghH-Index: 5
#2Asala Abu-AhmadH-Index: 1
Last. Carmela ShechnerH-Index: 10
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Purpose Studies on 1 μg low-dose test showed that among 1 μg cosyntropin samples pushed through long IV plastic tubing, some adrenocorticotropic hormone dosage was not recovered, and in healthy volunteers it provided subnormal cortisol responses. The aim of the current study is to assess whether there is any loss in adrenocorticotropic hormone 1–24 concentration when pushed through a short plastic tube, and to assess serum and salivary cortisol responses in low-dose test among healthy volunteers...
1 CitationsSource
#1Afif NakhlehH-Index: 2
#2Leonard SaieghH-Index: 5
Last. Carmela ShechnerH-Index: 10
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OBJECTIVE: Cushing’s disease during pregnancy is associated with an increased risk for maternal and fetal complications. In recurrent Cushing’s disease following transsphenoidal surgery, and when re-operation is not feasible, medical treatment is usually considered. Cabergoline was found to be effective in reducing hypercortisolism in Cushing’s disease. Evolving data concerning the safety of cabergoline use during pregnancy show no significant increase in the rate of complications during pregnan...
6 CitationsSource
#1Leonard SaieghH-Index: 5
#2Dean KerenH-Index: 9
Last. Carmela ShechnerH-Index: 10
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Summary Purpose In order to differentiate between Cushing's syndrome (CS) and Pseudo-Cushing's syndrome, it is customary to use a test that is conducted by cortisol suppression with low-dose dexamethasone, followed by the administration of corticotropin releasing hormone (Dex-CRH test). In children with severe obesity, Dex-CRH test has shown a specificity of 55%. The aim of current study was to evaluate the specificity of Dex-CRH test in morbid obese adults. Methods The study included a total of...
2 CitationsSource
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