scinapse is loading now...
Hyo Sang Lee
Oregon Health & Science University
8Publications
6H-index
914Citations
Publications 8
Newest
Jo Ann Janovick36
Estimated H-index: 36
(Oregon Health & Science University),
M. David Stewart17
Estimated H-index: 17
(University of Houston)
+ 14 AuthorsSuhujey Lopez4
Estimated H-index: 4
(University of Houston)
Many diseases result from genetic mutations that cause protein misfolding. Medical treatments often address the symptoms, but do not correct the underlying etiology. This study illustrates proof of principle that a disease caused by a misfolded cell surface receptor can be corrected with a pharmacoperone, a unique class of target-specific drugs that assist protein folding.
49 Citations Source Cite
Published on Jul 18, 2013in Cell 31.40
Masahito Tachibana14
Estimated H-index: 14
,
Paula Amato21
Estimated H-index: 21
+ 20 AuthorsHathaitip Sritanaudomchai9
Estimated H-index: 9
6 Citations Source Cite
Published on Jun 1, 2013in Cell 31.40
Masahito Tachibana14
Estimated H-index: 14
(Oregon National Primate Research Center),
Paula Amato21
Estimated H-index: 21
(Oregon Health & Science University)
+ 20 AuthorsHathaitip Sritanaudomchai9
Estimated H-index: 9
(Mahidol University)
Summary Reprogramming somatic cells into pluripotent embryonic stem cells (ESCs) by somatic cell nuclear transfer (SCNT) has been envisioned as an approach for generating patient-matched nuclear transfer (NT)-ESCs for studies of disease mechanisms and for developing specific therapies. Past attempts to produce human NT-ESCs have failed secondary to early embryonic arrest of SCNT embryos. Here, we identified premature exit from meiosis in human oocytes and suboptimal activation as key factors tha...
458 Citations Source Cite
Published on Jan 1, 2013in Nature 41.58
Masahito Tachibana14
Estimated H-index: 14
(Oregon Health & Science University),
Paula Amato21
Estimated H-index: 21
(Oregon Health & Science University)
+ 17 AuthorsHyo Sang Lee6
Estimated H-index: 6
(Oregon Health & Science University)
Mutations in mitochondrial DNA (mtDNA) are associated with severe human diseases and are maternally inherited through the egg’s cytoplasm. Here we investigated the feasibility of mtDNA replacement in human oocytes by spindle transfer (ST; also called spindle–chromosomal complex transfer). Of 106 human oocytes donated for research, 65 were subjected to reciprocal ST and 33 served as controls. Fertilization rate in ST oocytes (73%) was similar to controls (75%); however, a significant portion of S...
218 Citations Source Cite
Published on Nov 1, 2012in Developmental Biology 3.26
Masahito Tachibana14
Estimated H-index: 14
(Oregon National Primate Research Center),
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center)
+ 8 AuthorsYibing Jia1
Estimated H-index: 1
(Oregon National Primate Research Center)
Inactivation of one X chromosome in female mammals (XX) compensates for the reduced dosage of X-linked gene expression in males (XY). However, the inner cell mass (ICM) of mouse preimplantation blastocysts and their in vitro counterparts, pluripotent embryonic stem cells (ESCs), initially maintain two active X chromosomes (XaXa). Random X chromosome inactivation (XCI) takes place in the ICM lineage after implantation or upon differentiation of ESCs, resulting in mosaic tissues composed of two ce...
14 Citations Source Cite
Published on May 1, 2012in Cell Reports 8.03
Hyo Sang Lee6
Estimated H-index: 6
(Oregon National Primate Research Center),
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center)
+ 10 AuthorsPaula Amato21
Estimated H-index: 21
(Oregon Health & Science University)
The timing and mechanisms of mitochondrial DNA (mtDNA) segregation and transmission in mammals are poorly understood. Genetic bottleneck in female germ cells has been proposed as the main phenomenon responsible for rapid intergenerational segregation of heteroplasmic mtDNA. We demonstrate here that mtDNA segregation occurs during primate preimplantation embryogenesis resulting in partitioning of mtDNA variants between daughter blastomeres. A substantial shift toward homoplasmy occurred in fetuse...
66 Citations Source Cite
Published on Jan 1, 2012in Cell 31.40
Masahito Tachibana14
Estimated H-index: 14
(Oregon National Primate Research Center),
Michelle Sparman14
Estimated H-index: 14
(Oregon National Primate Research Center)
+ 4 AuthorsShoukhrat Mitalipov36
Estimated H-index: 36
(Oregon National Primate Research Center)
SUMMARY Totipotent cells in early embryos are progenitors of all stem cells and are capable of developing into a whole organism, including extraembryonic tissues such as placenta. Pluripotent cells in the inner cell mass (ICM) are the descendants of totipotent cells and can differentiate into any cell type of a body exceptextraembryonictissues.Theabilitytocontribute to chimeric animals upon reintroduction into host embryos is the key feature of murine totipotent and pluripotent cells. Here, we d...
103 Citations Source Cite
Published on Jul 1, 2011in Biology of Reproduction 3.18
Masahito Tachibana14
Estimated H-index: 14
(Oregon National Primate Research Center),
Michelle Sparman14
Estimated H-index: 14
(Oregon National Primate Research Center)
+ 6 AuthorsShoukhrat Mitalipov36
Estimated H-index: 36
(Oregon Health & Science University)
Source Cite
1