Nita G. Forouhi
Medical Research Council
Publications 315
#2Fumiaki ImamuraH-Index: 27
Last.Nita G. ForouhiH-Index: 3
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The risk of hepatic steatosis may be reduced through changes to dietary intakes, but evidence is sparse, especially for dietary patterns including the Mediterranean diet. We investigated the association between adherence to the Mediterranean diet and prevalence of hepatic steatosis. Cross-sectional analysis of data from two population-based adult cohorts: the Fenland Study (England, n = 9645, 2005–2015) and CoLaus Study (Switzerland, n = 3957, 2009–2013). Habitual diet was assessed using cohort-...
#1Javier I. OttavianiH-Index: 14
#2Reedmond Y. FongH-Index: 2
Last.Philip B. GraceH-Index: 13
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Data from dietary intervention studies suggest that intake of (−)-epicatechin mediates beneficial vascular effects in humans. However, population-based investigations are required to evaluate associations between habitual intake and health and these studies rely on accurate estimates of intake, which nutritional biomarkers can provide. Here, we evaluate a series of structurally related (−)-epicatechin metabolites (SREM), particularly (−)-epicatechin-3′-glucuronide, (−)-epicatechin-3′-sulfate and...
#1Laura B. L. Wittemans (University of Cambridge)H-Index: 2
#2Luca A. Lotta (University of Cambridge)H-Index: 12
Last.Lixia Zeng (TUM: Technische Universität München)H-Index: 14
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Circulating levels of glycine have previously been associated with lower incidence of coronary heart disease (CHD) and type 2 diabetes (T2D) but it remains uncertain if glycine plays an aetiological role. We present a meta-analysis of genome-wide association studies for glycine in 80,003 participants and investigate the causality and potential mechanisms of the association between glycine and cardio-metabolic diseases using genetic approaches. We identify 27 genetic loci, of which 22 have not pr...
#1Alexia Cardona (University of Cambridge)H-Index: 9
#2Felix R. Day (University of Cambridge)H-Index: 3
Last.Nicola D. Kerrison (University of Cambridge)H-Index: 9
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Epigenetic changes may contribute substantially to risks of diseases of ageing. Previous studies reported seven methylation variable positions (MVPs) robustly associated with incident type 2 diabetes mellitus (T2DM). However, their causal roles in T2DM are unclear. In an incident T2DM case-cohort study nested within the population-based EPIC-Norfolk cohort, we used whole blood DNA collected at baseline, up to 11 years before T2DM onset to investigate the role of methylation in the aetiology of T...
#1Katherine Cullerton (University of Cambridge)H-Index: 5
#2Jean Adams (University of Cambridge)H-Index: 29
Last.Martin White (University of Cambridge)H-Index: 102
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#1Htm Lai (Tufts University)
#2Fumiaki Imamura (University of Cambridge)H-Index: 27
Last.Matthias B. SchulzeH-Index: 67
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Background Type 2 diabetes (T2D) is a major risk factor associated with cardiometabolic diseases, and a major contributor towards mortality and morbidity, given its rapidly rising prevalence worldwide. In experimental studies, trans-fatty acids (TFAs) exert harmful biologic effects that may affect T2D risk, but findings from observational studies remain inconclusive, especially for biomarkers which provide an objective advantage with less recall bias and estimation errors. By pooling multiple st...
#1Tim Lindsay (University of Cambridge)
#2Kate Westgate (University of Cambridge)H-Index: 13
Last.Soren Brage (University of Cambridge)H-Index: 65
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Background: Physical activity (PA) plays a role in the prevention of a range of diseases including obesity and cardiometabolic disorders. Large population-based descriptive studies of PA, incorporating precise measurement, are needed to understand the relative burden of insufficient PA levels and to inform the tailoring of interventions. Combined heart and movement sensing enables the study of physical activity energy expenditure (PAEE) and intensity distribution. We aimed to describe the sociod...
#1Fumiaki ImamuraH-Index: 27
#2Matthias B. SchulzeH-Index: 67
Last.Dagfinn AuneH-Index: 37
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The InterAct project was funded by the EU FP6 program (LSHM_CT_2006_037197). InterAct investigators acknowledge funding from the following agencies: Medical Research Council Epidemiology Unit Core Support (MC_UU_12015/1, MC_UU_12015/5);
#1Yun Ju Sung (WashU: Washington University in St. Louis)H-Index: 17
#2Yun J. Sung (WashU: Washington University in St. Louis)H-Index: 7
Last.Helen R. Warren (QMUL: Queen Mary University of London)H-Index: 19
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